Liver position in fetal congenital diaphragmatic hernia retains a prognostic value in the era of lung-protective strategy

The impact of strict infection control on survival rate of prenatally diagnosed isolated congenital diaphragmatic hernia

“…All patients were managed by a lung-protective strategy and delayed surgery as described previously [7]. Briefly, all newborns were orally intubated immediately after birth and placed on a highfrequency oscillator with a FiO 2 of 1.0, a mean airway pressure (MAP) of 12 cmH 2 O, and a stroke volume (SV) of 10 ml.…”

Significance of pulmonary artery size and blood flow as a predictor of outcome in congenital diaphragmatic hernia

“…Persistent pulmonary hypertension (PPHN) is intimately associated with the pathophysiology of cardiopulmonary distress in CDH. To predict severity of PPHN and clinical outcome, several parameters such as fetal lung to thorax area ratio [4], liver position [5], fetal pulmonary artery (PA) size [6,7], and postnatal PA size and blood flow [8][9][10] have been reported to be reliable, but most are only assessed at a single point in time either prenatally or postnatally, and their change over time is not usually evaluated.…”

Congenital Diaphragmatic Hernia: State of the Art Reconstruction- Biologics Versus Synthetics

“…There are many indirect metrics for prenatal predictors of mortality which at best can estimate postnatal outcomes with variable accuracy. Those prenatal predictors of mortality include fetal liver position (Kunisaki et al, 2008;Kitano et al 2005;Hedrick et al, 2007), fetal lung volumes (Nishie et al, 2009) and lung area-to-head ratios (LHR) (Bretelle et al, 2007;Deprest et al, 2009). Notably all of these measures are proxies for the severity of underlying pulmonary hypoplasia secondary to the degree of visceral herniation.…”