The impact of strict infection control on survival rate of prenatally diagnosed isolated congenital diaphragmatic hernia

Morikawa, Nobuyuki; Kuroda, Takeshi; Honna, Toshiro; Kitano, Yoshihiro; Takayasu, Hajime; Ito, Yushi; Nakamura, Tomoo; Nakagawa, Satoshi; Hayashi, Satoshi; Sago, Haruhiko

doi:10.1007/s00383-008-2226-5

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Importantly, the number of PDA closures (81 in 1243 infants who survived > 72 hrs) is consistent with the report by Evans, who found about 10% of infants born before 27 weeks (and 3% of infants born at 27–29 weeks) required PDA surgical ligation [32]. Small number reports about the state of post-operative infants is insufficient [33,34]. …”

Section: Discussionsupporting

confidence: 80%

Late-onset bloodstream infections of Very-Low-Birth-Weight infants: data from the Polish Neonatology Surveillance Network in 2009–2011

et al. 2014

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BackgroundLate-Onset Bloodstream Infections (LO-BSI) continue to be one of the most important complications associated with hospitalization of infants born with very low birth weight (VLBW). The aims of this study were to assess the epidemiology of LO-BSI together with the risk factors and the distribution of causative pathogens at six Polish neonatal intensive care units that participated in the Polish Neonatology Surveillance Network from January 1, 2009 to December 31, 2011.MethodsThe surveillance covered 1,695 infants whose birth weights were <1501 grams (VLBW) in whom LO-BSI was diagnosed >72 hours after delivery. Case LO-BSI patients were defined according to NeoKISS.ResultsFour hundred twenty seven episodes of LO-BSI were diagnosed with a frequency of 25.3% and an incidence density of 6.7/1000 patient-days (pds). Results of our multivariate analysis demonstrated that surgical procedures and lower gestational age were significantly associated with the risk of LO-BSI. Intravascular catheters were used in infants with LO-BSI significantly more frequently and/or for longer duration: Central venous cathters (CVC) (OR 1.29) and Peripheral venous catheters (PVC) (OR 2.8), as well as, the total duration of total parenteral nutrition (13 vs. 29 days; OR 1.81). Occurrence of LO-BSI was significantly associated with increased the length of mechanical ventilation (MV) (OR 2.65) or the continuous positive airway pressure (CPAP) (OR 2.51), as well as, the duration of antibiotic use (OR 2.98). The occurrence of more than one infection was observed frequently (OR 9.2) with VLBW with LO-BSI. Microorganisms isolated in infants with LO-BSI were dominated by Gram-positive cocci, and predominantly by coagulase-negative staphylococci (62.5%).ConclusionsIndependent risk factor for LO-BSI in VLBV infants are: low gestational age and requirement for surgery. The incidence rates of LO-BSI especially CVC-BSI were higher in the Polish NICUs surveillance than those of other national networks, similar to the central- and peripheral utilization ratio.

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Section: Discussionsupporting

confidence: 80%

Late-onset bloodstream infections of Very-Low-Birth-Weight infants: data from the Polish Neonatology Surveillance Network in 2009–2011

et al. 2014

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“…Antenatal administration of sildenafil attenuated pulmonary vascular remodeling, which would lead us to expect less reactivity in pulmonary vascular tone at postnatal stages and probably, improved response to the therapeutic strategies such as inhaled nitric oxide. [34][35][36][37][38] In the fetal lung development, the branching pattern remains one of the main characteristics of organic growth and development. Pulmonary branching determines the efficient functioning of the mechanism for gas exchange from the environment to the human body and vice versa.…”

Section: Discussionmentioning

confidence: 99%

Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia

et al. 2014

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Infections following surgical patent ductus arteriosus ligation in very-low-birthweight neonates

Kopeć-Godlewska

Wójkowska‐Mach

2018

Journal of Hospital Infection

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The impact of strict infection control on survival rate of prenatally diagnosed isolated congenital diaphragmatic hernia

Abstract: The new supportive therapy with strict infection control improved survival rate of prenatally diagnosed CDH without using ECMO.

Cited by 3 publications

References 18 publications

Late-onset bloodstream infections of Very-Low-Birth-Weight infants: data from the Polish Neonatology Surveillance Network in 2009–2011

Late-onset bloodstream infections of Very-Low-Birth-Weight infants: data from the Polish Neonatology Surveillance Network in 2009–2011

Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia

Infections following surgical patent ductus arteriosus ligation in very-low-birthweight neonates

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