Liver metastasis of adenoid cystic carcinoma of salivary origin: report of a case prepared by ThinPrep method

Aninos, D.; Koumarianou, Anna; Georgoulakis, J.; Pektasidis, D.; E, Brountzos; Zoumpouli, C.; Ekonomopoulos, T.; Karakitsos, Peter

doi:10.1111/j.1365-2303.2006.00405.x

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…We were able to find in literature five clinical report of liver metastases from cancer of the salivary glands (four ACC and one Mucoepidermoid Carcinoma) and three cytopathology diagnosis case-report of liver DM from ACC [16,[27][28][29][30][31][32][33] (See Table 1). Zeidan [34] instead, reports an extended right hemihepatectomy for isolated DM from ACC of the lacrimal gland 20 years after resection of the primary tumor.…”

Section: Resultsmentioning

confidence: 99%

Recurrent adenoid cystic carcinoma in the liver: a repeated laparoscopic surgical approach

et al. 2011

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Adenoid cystic carcinoma (ACC) is characterized by a particularly aggressive behavior even many years after resection of primary tumor. The evolution of metastasis dramatically affects the final outcome but resection should always be evaluated. Herein is described a case of aggressive ACC of the parotid gland in a 30-year-old female. She developed local recurrence and lung metastases; then, she also developed two liver metastasis 112 and 132 months after the resection of the primitive cancer of the parotid gland. Both lesions were successfully managed by a laparoscopic approach. Intra-abdominal adhesions after the first surgery were mild, allowing an easier access for the second laparoscopic liver resection. At 1 year follow-up, the patient is liver disease free with a stable lung disease. To our knowledge, this is the first report of a double laparoscopic liver resection for parotid gland's ACC metachronous metastases. Patients with resected ACC need a strict and lifelong follow-up after the resection of the primitive cancer. Also for ACC, a laparoscopic approach to liver metastasis should always be considered as a viable alternative to open surgery. In our experience of over 90 cases, laparoscopic surgery causes less adhesions, allowing an easier approach for repeated resections.

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Section: Resultsmentioning

confidence: 99%

Recurrent adenoid cystic carcinoma in the liver: a repeated laparoscopic surgical approach

et al. 2011

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“…While distant metastasis may only become clinically manifest after a long period of time, evidence of micro-metastasis at the cellular level can often be detected earlier [7]. However, distant metastases typically occur after the diagnosis and treatment of the primary tumor, even many years afterward [2, 8–10]. The current case is only the third reported in the literature in which ACC of the submandibular gland presented in the unusual manner of a liver metastasis in the absence of spread elsewhere [4, 5].…”

Section: Discussionmentioning

confidence: 99%

Liver Metastasis as the Initial Presentation of Adenoid Cystic Carcinoma

et al. 2014

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“…We have not come across any previous report of metastasis of ACC occurrence before the primary tumor was detected, although there has been a suggestion that metastasis at the cellular level could occur many years prior to clinical presentation of the primary tumor. 2 There have been rare case reports of cytodiagnosis of metastasis of ACC to the liver, [6][7][8][9] where all of them occurred after an initial diagnosis of the primary had been made. The diagnosis may be rendered difficult if there is no history of the primary focus.…”

Section: Case Reportsmentioning

confidence: 99%

Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis

Deshpande

Kelkar

2008

Diagnostic Cytopathology

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Adenoid cystic carcinoma is a malignant tumor of the salivary glands. It is slow growing and is characterized by the delayed development of distant metastasis, which may develop even a decade or more after initial treatment of the primary tumor. We present the case of a 68-year-old male with complaints and radiological findings suggestive of primary hepatocellular carcinoma. However, fine-needle aspiration findings showed metastasis of adenoid cystic carcinoma. A retrospective clinical and ultrasound examination of the patient revealed a small asymptomatic enlargement of the submandibular salivary gland that was aspirated and showed features of adenoid cystic carcinoma. Diagn. Cytopathol. 2009;37:45-47. ' 2008 Wiley-Liss, Inc.Key Words: hepatic metastasis; initial; adenoid cystic carcinoma; primary; retrospective Adenoid cystic carcinoma (ACC) is a rare neoplasm and accounts for less than 1% of all head and neck malignancies and~10% of salivary neoplasms.1 It is however the most common malignant tumor of the submandibular, sublingual, and minor salivary glands. It is slow growing and shows multiple local recurrences. Distant metastasis is more common than regional lymph node metastasis. 2 Case ReportsA 68-year-old male patient presented with complaints of weight loss, an upper abdominal lump, and itching all over the body of 3 months duration. On examination, he had hepatomegaly, which was hard, nodular, and nontender, extending up to the right iliac fossa. An ultrasound (USG) and CT revealed multiple hypoechoic lesions surrounded by a hyperechoic rim involving both the lobes (Fig. 1), suggestive of hepatocellular carcinoma. Chest radiograph did not reveal any significant findings. USG-guided fine-needle aspiration (FNA) was carried out using a 22-gauge needle from multiple sites. Alcohol-fixed smears were stained by Papanicolaou (Pap) stain and hematoxylin and eosin stain. Air-dried smears were stained by May Grü nwald Giemsa (MGG) stain.FNA smears revealed basaloid tumor cells arranged in multilayered sheets and dispersed as single cells with high nucleo-cytoplasmic ratio. Nuclei were uniform in size, hyperchromatic, with coarsely granular chromatin and small nucleoli. Hyaline spherical globules of varying size with adherent tumor cells were seen, staining pale gray-blue with Pap ( Fig. 2) and bright magenta with MGG stain (Fig. 3). Reactive and normal hepatocytes were also present (Fig. 4). A diagnosis of ACC was made. The patient was then examined for the possible site of origin, and was found to have an asymptomatic left submandibular swelling of size 1 3 1 cm. USG-guided FNA was then carried out from this submandibular mass that showed cytological features of ACC. DiscussionACC is a malignant tumor that is characterized by slow growth, multiple local recurrences, and a prolonged clinical course often with delayed development of distant metastasis. The organs involved in decreasing order of frequency are lung, bone, brain, and liver.3 Other rare metastatic sites include stomach, choroids, kidney, and skin....

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Liver metastasis of adenoid cystic carcinoma of salivary origin: report of a case prepared by ThinPrep method

Cited by 6 publications

References 4 publications

Recurrent adenoid cystic carcinoma in the liver: a repeated laparoscopic surgical approach

Recurrent adenoid cystic carcinoma in the liver: a repeated laparoscopic surgical approach

Liver Metastasis as the Initial Presentation of Adenoid Cystic Carcinoma

Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis

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