Liver Metastasis as the Initial Presentation of Adenoid Cystic Carcinoma

Spolverato, Gaya; Fite, J. Judd; Bishop, Justin A.; Argani, Pedram; Pawlik, Timothy M.

doi:10.1007/s10620-014-3078-6

Cited by 15 publications

(8 citation statements)

References 9 publications

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“…According to our current knowledge, only 3 cases of isolated liver metastasis that presented as the first clinical sign from parotid ACC were reported. 7-9…”

Section: Discussionmentioning

confidence: 99%

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A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

Zemni

Tounsi

Bouraoui

et al. 2019

Journal of Investigative Medicine High Impact Case Reports

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Adenoid cystic carcinoma is an uncommon malignant neoplasm of the salivary gland. Liver metastasis from salivary gland cancer is a rare situation. In this article, we report the case of a 29-year-old woman treated 5 years previously for adenoid cystic carcinoma of the parotid gland by surgery and radiotherapy, who presented for a large hypervascularized hepatic metastasis of 20 cm. After 3-cycle chemotherapy stability, hepatic surgery was successfully performed. The patient maintained disease-free period of 12 months after the surgical treatment. This rare case represents a therapeutic challenge for oncologists and surgeons. Through this case and a review of the literature, we try to better detail the management of this uncommon entity.

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“…According to our current knowledge, only 3 cases of isolated liver metastasis that presented as the first clinical sign from parotid ACC were reported. 7-9…”

Section: Discussionmentioning

confidence: 99%

“…5 According to our current knowledge, only 3 cases of isolated liver metastasis that presented as the first clinical sign from parotid ACC were reported. [7][8][9] Few studies of isolated metastatic liver were reported in the literature. Their management was still debatable.…”

Section: Discussionmentioning

confidence: 99%

A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

Zemni

Tounsi

Bouraoui

et al. 2019

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

show abstract

“…[24][25][26][27] Lung is the most common site of metastasis followed by bone whereas brain and liver are much less common sites for metastasis. [24][25][26][27][28][29][30] Liver is rarely the only site of metastasis. [24][25][26][27][28][29][30] Liver metastasis may be the first sign of presentation.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26][27][28][29][30] Liver is rarely the only site of metastasis. [24][25][26][27][28][29][30] Liver metastasis may be the first sign of presentation. [15][16] Besides adenoid cystic carcinoma of salivary glands, adenoid cystic carcinoma from other sites such as vulva, 31 trachea, 32 lacrimal gland 33 has also been reported to metastasize to the liver.…”

Section: Discussionmentioning

confidence: 99%

Primary Adenoid Cystic Carcinoma of the Liver: Case Report and Review of the Literature

Zhang

Wang

Cao

2018

Annals of Hepatology

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Adenoid cystic carcinoma (ACC) is an uncommon tumor primarily occurring in the salivary glands and is relatively rare in other sites. In the liver, only one primary adenoid cystic carcinoma has been reported in the English literature. Here we presented a primary hepatic adenoid cystic carcinoma in a 44 years old male. We described its histopathologic features and its immunohistochemical profile, and reviewed the literature. The surgical treatment and patient follow up information was also presented.

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“…Infrequently, metastatic lesions can be found at the time of diagnosis of ACC; however, these cases almost always originate from salivary gland ACC [10,11,12]. Three previous reports have described isolated liver metastases found at the time of diagnosis of ACC, with all of them initially presenting with abdominal symptoms; all three of these cases found the primary malignancy to originate from the submandibular glands [13,14,15]. We report a rare case of primary ACC of the lacrimal gland diagnosed concurrently with isolated metastatic liver lesions.…”

Section: Discussionmentioning

confidence: 99%

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

Maamari¹,

Custer²,

Harocopos³

2017

Ocul Oncol Pathol

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Aim: To report a rare presentation of adenoid cystic carcinoma (ACC) of the lacrimal gland. Method: This is a case report presenting clinical, radiographic, and histopathologic findings. Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with ACC. She was then referred to the ophthalmology service, where ocular examination demonstrated 2.5 mm of right proptosis with elevation and abduction deficits. Diplopia could be elicited in extreme upgaze and right lateral gaze. An excisional biopsy of the orbital mass was performed, with histopathology confirming the diagnosis of primary ACC of the lacrimal gland, thereby also supporting the initial suspicion that the hepatic ACC lesions represented metastases. Conclusion: The authors describe a rare presentation of ACC of the lacrimal gland, initially asymptomatic, with metastatic lesions restricted to the liver at the time of diagnosis. Three previous cases of ACC with isolated metastatic hepatic lesions at the time of diagnosis have been reported; all of these cases localized the primary tumor to the salivary glands.

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Liver Metastasis as the Initial Presentation of Adenoid Cystic Carcinoma

Cited by 15 publications

References 9 publications

A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

Primary Adenoid Cystic Carcinoma of the Liver: Case Report and Review of the Literature

Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases

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