Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl 4 -induced liver injury

Guo, Qing; Zhang, Qianqian; Chen, Jiaqing; Wei, Zhang; Qiu, Hong-Cong; Zhang, Zunjian; Liu, Buming; Xu, Fengguo

doi:10.1016/s1875-5364(17)30078-x

Cited by 15 publications

(12 citation statements)

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“…Methanolic extracts of P. urinaria whole plant inhibit CCl 4 -induced acute liver damage through modulation of serum glutamate-pyruvate-transaminase and glutathione peroxidase in vivo (Prakash et al, 1995 ; Lee et al, 2006 ). These results are supported by a recent study in vivo indicating that P. urinaria attenuates CCl 4 -induced hepatotoxicity by regulation of L-carnitine, taurocholic acid, and amino acid metabolisms (Guo et al, 2017 ). Acetone extracts from whole plant of P. urinaria inhibit Hepatitis C virus infection in vitro (Chung et al, 2016 ).…”

Section: Pharmacological Activities Of P Urinaria supporting

confidence: 77%

A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

Geethangili

Ding

2018

Front. Pharmacol.

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The genus Phyllanthus (L.) is one of the most important groups of plants belonging to the Phyllantaceae family. Phyllanthus urinaria (L.) is an annual perennial herbal species found in tropical Asia, America, China, and the Indian Ocean islands. P. urinaria is used in folk medicine as a cure to treat jaundice, diabetes, malaria, and liver diseases. This review provides traditional knowledge, phytochemistry, and biological activities of P. urinaria. The literature reviewed for this article was obtained from the Web of Science, SciFinder, PubMed, ScienceDirect, and Google Scholar journal papers published prior to December 2017. Phytochemical investigations reveal that the plant is a rich source of lignans, tannins, flavonoids, phenolics, terpenoids, and other secondary metabolites. Pharmacological activities include anticancer, hepatoprotective, antidiabetic, antimicrobial, and cardioprotective effects. Thus, this present review summarizes the phytochemical constituents and their biological activities including biological studies on various crude extracts and fractions both in vitro and in vivo, and on clinical trial information about P. urinaria. This review compiles 93 naturally occurring compounds from P. urinaria along with their structures and pharmacological activities. The review is expected to stimulate further research on P. urinaria, and its pharmacological potential to yield novel therapeutic agents.

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Section: Pharmacological Activities Of P Urinaria supporting

confidence: 77%

A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

Geethangili

Ding

2018

Front. Pharmacol.

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“…As a traditional Chinese medicine, Qizhu decoction, which contains Phyllanthus urinaria , Polygonum cuspidatum , Hedyotis diffusa , Paeonia lactiflora , Paeonia veitchii , Rhizoma Smilacis Glabrae , and Salvia miltiorrhiza 16 , has been widely used in China. Several compounds that have been isolated from P. cuspidatum and P. urinaria , such as corilagin, polydatin, resveratrol, quercetin, emodin, and rutin, among others, exert significant hepatoprotective effects against CCl 4 -induced acute liver injury and HBV-induced hepatitis in mice, and the underlying mechanisms might be related to their antioxidant and anti-inflammatory effects 18,19,21,29,31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…We first prepared extracts of Qizhu decoction (provided by Nanjing University of Traditional Chinese Medicine) as follows: the plants were ground and extracted with either double-distilled water or 70% ethanol according to previously described method 16,22 . Both the aqueous extract (QC) and the 70% ethanol extract (QS) were then dried to a powder, dissolved in phosphate buffered saline (PBS) to obtain a concentration of 100 mg/mL, and stored at −20 °C.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we focused on extracts from Qizhu decoction, a formula used in traditional Chinese medicine. Qizhu decoction consists of several herbal components, namely Phyllanthus urinaria , Polygonum cuspidatum , Hedyotis diffusa , Paeonia lactiflora , Paeonia veitchii , Rhizoma Smilacis Glabrae , and Salvia miltiorrhiza 16 . Furthermore, this decoction has been used to promote blood circulation and particularly to enhance the body’s immunity 17 and also facilitates the restoration of thymus atrophy and hypofunction caused by malnutrition.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, this decoction has been used to promote blood circulation and particularly to enhance the body’s immunity 17 and also facilitates the restoration of thymus atrophy and hypofunction caused by malnutrition. Moreover, it has been reported that compounds or extracts from P. urinaria and P. cuspidatum exhibit antioxidant activity 17 , inhibit HBV-induced hepatitis 18–20 , and show activity against CCl 4 -induced liver injury and schistosomiasis-induced hepatic fibrosis 16,21 . However, the effects of extracts of Qizhu decoction on HCC are not well understood.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling

Wan

Shen

Wang

et al. 2019

Sci Rep

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Hepatitis and hepatocellular carcinoma are serious human diseases. Here, we examined the in vivo and in vitro inhibitory effect of extracts of Qizhu decoction (a traditional Chinese medicine) on hepatitis caused by diethylnitrosamine or hepatitis B virus and on diethylnitrosamine-induced hepatocellular carcinoma. The results showed that both the aqueous and ethanol extracts (QC and QS, respectively) of Qizhu decoction significantly inhibited hepatic inflammation and liver cancer induced by diethylnitrosamine or hepatitis B virus by suppressing NF-κB signaling and decreasing the levels of TNF-α and IL-1β. Both QC and QS inhibited the proliferation and migration of primary cancer hepatocytes by reducing cyclin B1, cyclin D1 and N-cadherin expression and increasing E-cadherin expression. QC and QS also promoted the apoptosis of primary cancer hepatocytes by upregulating caspase-3 and downregulating BCL-2 expression. The knockdown of p65 in NF-κB signaling inhibited the ability of QC and QS to significantly reduce the colony formation ability of liver cancer cells. Additionally, QC and QS might significantly inhibit the DNA replication of hepatitis B virus in vivo and in vitro, and we found that corilagin and polydatin were the active compounds of QC and QS. Taken together, our in vitro findings and our results in C57BL/6 mice showed that extracts of Qizhu decoction might inhibit hepatitis and hepatocellular carcinoma by suppressing NF-κB signaling.

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Metabolomics analysis of sea cucumber (Apostichopus japonicus) in different geographical origins using UPLC–Q-TOF/MS

Zhao

Han

et al. 2020

Food Chemistry

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Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl 4 -induced liver injury

Cited by 15 publications

References 50 publications

A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

Extracts of Qizhu decoction inhibit hepatitis and hepatocellular carcinoma in vitro and in C57BL/6 mice by suppressing NF-κB signaling

Metabolomics analysis of sea cucumber (Apostichopus japonicus) in different geographical origins using UPLC–Q-TOF/MS

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