Liver Metabolism and Contraceptive Steroids

Oral contraceptives and liver function

“…Other enzymes The level of serum ornithine transcarbamylase is raised in pregnancy (Reichard, Wigvist, and Yllener, 1961) and during the first month of oral contraceptive therapy (Brohult and Westgren, 1965). The level of serum leucine aminopeptidase is raised in pregnancy (Green, Tsou, Bressler, and Seligman, 1955).…”

Liver Reaction in Connection with Oral Contraceptive Steroids

“…Rises in serum transaminases (Knutson et al, 1965;Larsson-Cohn, 1966;Orellana-Alcalde and Dominguez, 1966) and in serum ornithine carbamoyl transferase (S-OCT) (Brohult and Westgren, 1965) have been observed after contraceptive steroids and an increase in bromsulphthalein retention has also been demonstrated after peroral contraceptives (Eisalo et al, 1964;Larsson-Cohn, 1967). OCT was considered to be a particularly suitable enzyme for this study, since it occurs only in the liver and even a minor disturbance in this organ elicits a rise i S-OCT (Reichard, 1962).…”