Liver in systemic disease

Shimizu, Yukihiro

doi:10.3748/wjg.14.4111

Cited by 67 publications

(53 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, these results describe the orders of medical behaviors, and they will be incorporated into the HIS to aid physicians. The specific laboratory tests found in our study are compatible with the studies in two review articles focusing on liver diseases [25,26]. Our data-mining system provides physicians with interesting rules, which also contain clinical values.…”

Section: Resultssupporting

confidence: 61%

A Data-Mining Framework for Transnational Healthcare System

Shen

Jigjidsuren²,

Dorjgochoo

et al. 2011

J Med Syst

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Medical resources are important and necessary in health care. Recently, the development of methods for improving the efficiency of medical resource utilization is an emerging problem. Despite evidence supporting the use of order sets in hospitals, only a small number of health information systems have successfully equipped physicians with analysis of complex order sequences from clinical pathway and clinical guideline. This paper presents a data-mining framework for transnational healthcare system to find alternative practices, including transfusion, pre-admission tests, and evaluation of liver diseases. However, individual countries vary with respect to geographical location, living habits, and culture, so disease risks and treatment methods also vary across countries. To realize the difference, a service-oriented architecture and cloud-computing technology are applied to analyze these medical data. The validity of the proposed system is demonstrated in including Taiwan and Mongolia, to ensure the feasibility of our approach.

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Section: Resultssupporting

confidence: 61%

A Data-Mining Framework for Transnational Healthcare System

Shen

Jigjidsuren²,

Dorjgochoo

et al. 2011

J Med Syst

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“…A rise in plasma ALT activities is indicative of an injury to the cytoplasmic membrane in the cell. It is a specific biomarker for cytoplasmic and mitochondrial injuries where its high concentration is greater than that of AST [33]. It is increased in acute viral hepatitis (ALT>AST), biliary tract obstruction (cholangitis, choledocholithiasis), alcoholic hepatitis and cirrhosis (AST>ALT), liver abscess, metastatic or primary liver cancer; right heart failure, ischemia or hypoxia, injury to liver ("shock liver"), extensive trauma.…”

Section: Enzymes Found Mainly In Livermentioning

confidence: 99%

“…Bile duct and pancreas carcinomas cause extrahepatic obstruction of bile duct thus leading to increase in conjugated serum bilirubin. Non-Hodgkin's lymphomas and autoimmune primary biliary cirrhosis may also obstruct bile ducts causing increase in conjugated bilirubin in serum [33].…”

Section: Heme → Biliverdin → Bilirubin → Conjugated Bilirubinmentioning

confidence: 99%

Biochemical Markers of In Vivo Hepatotoxicity

Wm¹,

DW²

2016

J Clin Toxicol

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A chemical compound, whether of natural or of synthetic origin, brings about a toxicological effect when its dose is high enough or the duration of exposure is sufficient to cause an alteration in the normal homeostasis of body fluids and tissues. Therefore, the right dose differentiates a toxicant from a remedy. The body detoxifies drugs and other chemical compounds through key organs such as the liver. The liver plays a central role in the metabolism and excretion of xenobiotics which makes it highly susceptible to their adverse and toxic effects. These effects can be manifested in the form of hepatic injuries, which take many forms from cellular degeneration and necrosis to cirrhosis or cholestasis to vascular injury. Exposure to hepatotoxicants alters the homeostatic balance of various biological markers that provides a powerful and dynamic approach to understanding the spectrum of liver diseases. These markers offer a means for homogeneous classification of a disease and risk factor, and they can extend one's basic information about the underlying pathogenesis of disease and in drug design.

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“…Potential causes of abnormal hepatic function include viral hepatitis, autoimmune liver diseases, hepatobiliary diseases and systemic infection, including agents such as Mycobacterium spp. and Leishmania spp (Shimizu, 2008). Liver disease is also reported in fattened animals (pigs and geese), in females in late pregnancy (especially cows), and in bulls, chickens and cuttlefish (Santos, 1975).…”

Section: Introductionmentioning

confidence: 99%

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

et al. 2018

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The six-banded armadillo (Euphractus sexcinctus) stands out among wild mammals due to the rare occurrence of spontaneous metabolic diseases. When altered, the liver, which is important in metabolism, may trigger a dysfunctional cascade, leading to hepatic steatosis. Here we describe a case of hepatic steatosis in a six-banded armadillo living in captivity. The female specimen was captured and donated to the Federal University of Piaui under SISBIO authorization nº53303. The animal was first referred for a veterinary clinical evaluation, and then euthanized following the ethical standards of the Federal Council of Veterinary Medicine. At the start of the dissection, the abdominal cavity was accessed and sections of all ex situ liver lobes, spleen and mandibular lymph node were subjected to routine histological processing; the results were photo documented. The anatomic and histopathological analysis confirmed the diagnosis of hepatic steatosis, which we propose is related to an infectious process as a result of the changes observed in the organs of the lymphoid system. This report of fatty liver disease in armadillo suggests an acute infectious process with lymphoid system involvement. Keywords: Euphractus sexcinctus, infectious, liver, six-banded armadillo, steatosis. Esteatose hepática em tatu-peba (Euphractus sexcinctus Linnaeus, 1758)Resumo: O tatu-verdadeiro (Euphractus sexcinctus) se destaca entre os mamíferos selvagens devido à rara ocorrência de doenças metabólicas espontâneas. Quando alterado, o fígado, que é importante no metabolismo, pode desencadear uma cascata disfuncional, levando a esteatose hepática. Foi descrito um caso de esteatose hepática em um tatu-verdadeiro vivendo em cativeiro. O espécime feminino foi capturado e doado para a Universidade Federal do Piauí sob a autorização SISBIO nº53303. O animal foi encaminhado para uma avaliação clínica veterinária e, depois, submetido à eutanásia seguindo os padrões éticos do Conselho Federal de Medicina Veterinária. No início da dissecção, acessou-se a cavidade abdominal e as seções de todos os lóbulos do fígado ex situ, do baço e do linfonodo mandibular foram submetidos ao processamento histológico de rotina. Os resultados foram fotomicrografados e documentados. A análise anatômica e histopatológica confirmou o diagnóstico de esteatose hepática, que está relacionada a um processo infeccioso como resultado das mudanças observadas nos órgãos do sistema linfóide. Este relatório de doença hepática gordurosa no armadillo sugere um processo infeccioso agudo com comprometimento do sistema linfático. Euphractus sexcinctus, infecção, fígado, tatu-verdadeiro, esteatose. Palavras-chaves:

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Liver in systemic disease

Cited by 67 publications

References 85 publications

A Data-Mining Framework for Transnational Healthcare System

A Data-Mining Framework for Transnational Healthcare System

Biochemical Markers of In Vivo Hepatotoxicity

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

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