Liver hamartomas in tuberous sclerosis

Cheung, Hoiwan; Ambrose, Robert; Lee, P.O.

doi:10.1016/s0009-9260(05)81064-5

Cited by 19 publications

(9 citation statements)

References 9 publications

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“…It was 8 cm in diameter. Again large kidney lesions were also present in both cases and might have caused these patients' symptoms [7]. The authors wonder what tumor size causes symptoms or carries a high risk of non-traumatic hemorrhage and what is the natural history of a hepatic angiomyolipoma in TSC.…”

Section: Size Growth and Symptomsmentioning

confidence: 99%

Ruptured hepatic angiolipoma in tuberous sclerosis complex

Huber

Treutner

Steinau

et al. 1996

Langenbecks Arch Chir

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Tuberous sclerosis complex (TSC) may be associated with hepatic angiomyolipoma. In contradistinction to renal angiomyolipoma this lesion is rare, and nontraumatic hemorrhage has not so far been described. This is the first report of a spontaneously ruptured, surgically treated and histologically verified, hepatic angiomyolipoma in TSC. Anomalies of the vessel walls and consequently the hazard of bleeding are known to increase with the diameter of the tumor in other localizations. It is concluded that in cases with rapid tumor growth and marked vessel anomalies elective surgery should be considered.

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Section: Size Growth and Symptomsmentioning

confidence: 99%

Ruptured hepatic angiolipoma in tuberous sclerosis complex

Huber

Treutner

Steinau

et al. 1996

Langenbecks Arch Chir

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“…At ultrasound the lesions typically appear as hyperechoic masses [5, 8±10, 12, 27], although some authors reported a hypoechoic texture [6,11]. This characteristic finding is probably a result of proliferation of blood vessels and presence of fatty tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Tumor sizes of 0.2 to 28 cm have been reported [10,11]. Due to the abundance of vascular structures with degenerated vessel walls and small aneurysms, a propensity to spontaneous hemorrhage might be expected.…”

Section: Discussionmentioning

confidence: 99%

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Multiple hepatic angiolipomas: a case report and review of literature

1999

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Follow-up of two hepatic angiolipomas in a patient without evidence of tuberous sclerosis is reported. Initially, the lesions presented as homogenously enhancing masses, which were nearly isodense to normal liver tissue on plain CT scans. Focal nodular hyperplasia was assumed. One year later, fat was detected in the growing tumors and percutaneous core biopsy revealed hepatic angiolipomas. Natural history of these rare lesions is unknown, and this is to the best of our knowledge the first observation of fatty metamorphosis in such a benign, mesenchymal hepatic neoplasm.

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“…[12][13]22,[25][26] Asymptomatic hepatic hamartomas were found in 23.5% of children with TS. 33 Case reports [34][35] document their presence in other individuals; although not clinically significant, they may help diagnose asymptomatic individuals.…”

Section: (B)mentioning

confidence: 99%

Guidelines and care pathways for genetic diseases: the Scottish collaborative project on tuberous sclerosis

et al. 1998

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In Scotland a national audit project has been undertaken to devise evidencebased guidelines for the clinical management of patients with tuberous sclerosis (TS), a dominantly inherited multisystem disorder. In order to facilitate the audit and use of these guidelines a 'Care Pathway' was devised to form the patient records. We describe the process of guideline development for TS and our TS Care Pathway.

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Liver hamartomas in tuberous sclerosis

Cited by 19 publications

References 9 publications

Ruptured hepatic angiolipoma in tuberous sclerosis complex

Ruptured hepatic angiolipoma in tuberous sclerosis complex

Multiple hepatic angiolipomas: a case report and review of literature

Guidelines and care pathways for genetic diseases: the Scottish collaborative project on tuberous sclerosis

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