Liver Function Tests in Survivors of Haemolytic Disease of The Newborn

Bird, T.; Cassells-Smith, A. J.; Walker, William E.

doi:10.1136/adc.38.202.561

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Discussion1

Discussion and Review Of Literature1

Syndrome Of Hepatocellular Damage In This Newborn1

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2013

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Cited by 3 publications

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“…The second cause was inspissated bile which is often secondary to the increased demand on the biliary system from excessive bilirubin load (8), and is usually associated with a benign clinical course (27). It is thought that the excessive bilirubin load presented to the liver causes blockage of the ducts during excretion (28).…”

Section: Discussionmentioning

confidence: 99%

Conjugated hyperbilirubinemia in the neonatal intensive care unit

Ipek¹,

Aydın²,

Zencıroğlu³

et al. 2013

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Conjugated hyperbilirubinemia in the neonatal intensive care unit

Ipek¹,

Aydın²,

Zencıroğlu³

et al. 2013

Turk J Gastroenterol

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“…Recent authors highlight the term ‘syndrome of hepatocellular damage’ (13,14) to a condition HDN with hepatic dysfunction and conjugated hyperbilirubinemia. Fortunately, infants who are adequately treated and survive HDN do not go into chronic liver disease in later years (7).…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…Evidence of hepatic obstruction may persist for several weeks. Syndrome invariably disappears and infants are not left with any permanent hepatic damage or subsequent chronic liver disease (7).…”

Section: Syndrome Of Hepatocellular Damage In This Newbornmentioning

confidence: 99%

Rh iso-immunisation with syndrome of hepatocellular damage. An unusual presentation with review of literature

Thaplial

Ramachandran

Sharma

et al. 2004

International Journal of Clinical Practice

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Rh iso-immunisation is prevalent in many underdeveloped countries. Severe haemolytic anaemia with or without hydrops fetalis, dangerous level of haemolytic unconjugated bilirubin and imminent bilirubin encephalopathy are the hallmarks of haemolytic disease of the newborn. The investigative protocols and efficient management of this entity are adequately described in literature. An unusual manifestation of this disease with severe hepatocellular damage and conjugated hyperbilirubinemia was noticed in a neonate. The literature has been reviewed and the specific symptom complex has been attributed to 'syndrome of hepatocellular damage', which is a rare accompaniment of haemolytic disease of the newborn. Attempts have been made to describe the syndrome in detail, with latest reference regarding complete workup and management. Few useful tips for prevention of the disease in a community background have been suggested.

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