Liver fibrogenesis marker, 7S domain of collagen type IV in patients with acutely decompensated heart failure: Correlates, prognostic value and time course

Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction

“…29 Unlike type I and type III collagens, which are processed by proteolysis, type IV collagen is deposited intact in the matrix and the serum component of type IV collagen reflects matrix degradation. 20 Circulating markers of plausible systemic fibrosis and collagen turnover, such as procollagen type III collagen Liver fibrosis score predicts mortality of HFpEF aminoterminal peptide as metabolites of PIIIP, [33][34][35][36] type IV collagen, 36,37 carboxy-terminal telopeptide of collagen type I, 33,35 and growth differentiation factor 15, 38 are associated with cardiac remodelling and adverse prognosis in HF patients. [33][34][35]38 Elevated circulating levels of type III collagen is associated with increased aortic fibrosis and stiffness, 39 increased myocardial collagen types I and III, 33 systolic and diastolic dysfunction of right and left ventricles in hypertensive patients, 35,40 and diastolic dysfunction in HFpEF patients 39,41,42 and is partly associated with adverse prognosis in HFpEF patients.…”

Circulating markers of collagen types I, III, and IV in patients with dilated cardiomyopathy: relationships with myocardial collagen expression

“…15,22 In HF, the liver is susceptible to haemodynamic stress-induced injury as reflected by elevation of LFTs in a significant proportion of patients. 10,26 Monitoring P4NP 7S in HF patients would provide information on the status of haemodynamic stress-induced organ injury and its pathological consequences. This speculation was also supported by the recent findings showing that P4NP 7S was significantly correlated with calculated liver fibrosis score or another liver fibrosis marker, hyaluronic acid.…”

“…This speculation was also supported by the recent findings showing that P4NP 7S was significantly correlated with calculated liver fibrosis score or another liver fibrosis marker, hyaluronic acid. 10,26 Monitoring P4NP 7S in HF patients would provide information on the status of haemodynamic stress-induced organ injury and its pathological consequences. Notably, there are several reports showing that PIIINP is also elevated and reflects liver fibrosis in patients with primary liver disease.…”

“…4 They have been conventionally used as surrogates of cardiac fibrosis in a number of studies on ischaemia heart disease, hypertensive heart disease, or chronic heart failure (HF). 10,11 While cardiac fibrosis is the most important pathological feature of cardiac remodelling, emerging evidences suggest that haemodynamic disturbance accompanying HF involves extra-cardiac organs such as the kidneys and the liver. 10,11 While cardiac fibrosis is the most important pathological feature of cardiac remodelling, emerging evidences suggest that haemodynamic disturbance accompanying HF involves extra-cardiac organs such as the kidneys and the liver.…”

“…[5][6][7][8][9] In addition, we and others have recently reported that breakdown peptide of 7S domain of collagen type IV (P4NP 7S), another type of collagen composing the basement membrane in the ECM, was correlated with haemodynamics and had potential prognostic utility in patients with acutely decompensated HF. 10,11 While cardiac fibrosis is the most important pathological feature of cardiac remodelling, emerging evidences suggest that haemodynamic disturbance accompanying HF involves extra-cardiac organs such as the kidneys and the liver. 12 Injury to those organs may activate pro-fibrotic response, leading to the release of collagen peptides.…”