Liver fat volume fraction quantification with fat and water T1 and T2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

Leporq, Benjamin; Ratiney, H.; Pilleul, F.; Beuf, Olivier

doi:10.1007/s00330-013-2826-x

Cited by 28 publications

(33 citation statements)

References 42 publications

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“…The lipid T 1 we found is higher than previously reported by Leporq et al However, our result agrees well with the subcutaneous fat T 1 (382 ± 13 msec) value . Liver water T 1 were published by Leporq et al and de Bazelaire et al (Table ). Fundamentally different MRI water‐fat signal separation methods and T 1 quantification approaches could explain the lower fat and water T 1 values compared to our results.…”

Section: Discussionsupporting

confidence: 91%

“…At 7T, relaxation times T 1 (1084 ± 52 msec) and T 2 (32 ± 9 msec) of healthy human liver were estimated by Gajdosik et al Our results are in line with these two measurements, taking into account the fact that increased field strength leads to increased T 1 and to a minor decrease in T 2 . Just one 3T study was dedicated to quantify T 1 of the liver lipid (CH 2 ) n , and two works evaluated water T 1 , in spite of strong signals of both components (Table ). The lipid T 1 we found is higher than previously reported by Leporq et al However, our result agrees well with the subcutaneous fat T 1 (382 ± 13 msec) value .…”

Section: Discussionmentioning

confidence: 99%

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Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Weis

Kullberg

Åhlström

2017

Magnetic Resonance Imaging

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Weis

Kullberg

Åhlström

2017

Magnetic Resonance Imaging

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“…Liver fat fraction and T 2 *, reflecting iron content, can be calculated with chemical shift‐encoded gradient‐echo magnetic resonance imaging (MRI) . Nevertheless, these methods alone cannot assess fibrosis and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous MR quantification of hepatic fat content, fatty acid composition, transverse relaxation time and magnetic susceptibility for the diagnosis of non‐alcoholic steatohepatitis

et al. 2017

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Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH relative to simple steatosis have also been reported. Therefore, our aim was to develop a single magnetic resonance (MR) acquisition and post-processing scheme for the diagnosis of steatohepatitis by the simultaneous quantification of hepatic fat content, fatty acid composition, T * transverse relaxation time and magnetic susceptibility in patients with non-alcoholic fatty liver disease. MR acquisition was performed at 3.0 T using a three-dimensional, multi-echo, spoiled gradient echo sequence. Phase images were unwrapped to compute the B field inhomogeneity (ΔB ) map. The ΔB -demodulated real part images were used for fat-water separation, T * and fatty acid composition quantification. The external and internal fields were separated with the projection onto dipole field method. Susceptibility maps were obtained after dipole inversion from the internal field map with single-orientation Bayesian regularization including spatial priors. Method validation was performed in 32 patients with biopsy-proven, non-alcoholic fatty liver disease from which 12 had simple steatosis and 20 NASH. Liver fat fraction and T * did not change significantly between patients with simple steatosis and NASH. In contrast, the saturated fatty acid fraction increased in patients with NASH relative to patients with simple steatosis (48 ± 2% versus 44 ± 4%; p < 0.05) and the magnetic susceptibility decreased (-0.30 ± 0.27 ppm versus 0.10 ± 0.14 ppm; p < 0.001). The area under the receiver operating characteristic curve for magnetic susceptibility as NASH marker was 0.91 (95% CI: 0.79-1.0). Simultaneous MR quantification of fat content, fatty acid composition, T * and magnetic susceptibility is feasible in the liver. Our preliminary results suggest that quantitative susceptibility imaging has a high diagnostic performance for the diagnosis of NASH.

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“…It is the T 1 of the water component which appears to be of diagnostic significance when using T 1 mapping in the liver,14 while the T 1 of the fat is constant15 and not a predictor of disease. An important step towards the use of MOLLI T 1 to assess liver disease is the clarification and quantification of the extent to which the presence of fat can mask or exaggerate changes in MOLLI T 1 due to disease.…”

mentioning

confidence: 99%

Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

Mózes

Tunnicliffe

Pavlides

et al. 2016

Magnetic Resonance Imaging

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PurposeTo characterize the effect of fat on modified Look–Locker inversion recovery (MOLLI) T 1 maps of the liver. The balanced steady‐state free precession (bSSFP) sequence causes water and fat signals to have opposite phase when repetition time (TR) = 2.3 msec at 3T. In voxels that contain both fat and water, the MOLLI T 1 measurement is influenced by the choice of TR.Materials and MethodsMOLLI T 1 measurements of the liver were simulated using the Bloch equations while varying the hepatic lipid content (HLC). Phantom scans were performed on margarine phantoms, using both MOLLI and spin echo inversion recovery sequences. MOLLI T 1 at 3T and HLC were determined in patients (n = 8) before and after bariatric surgery.ResultsAt 3T, with HLC in the 0–35% range, higher fat fraction values lead to longer MOLLI T 1 values when TR = 2.3 msec. Patients were found to have higher MOLLI T 1 at elevated HLC (T 1 = 929 ± 97 msec) than at low HLC (T 1 = 870 ± 44 msec).ConclusionAt 3T, MOLLI T 1 values are affected by HLC, substantially changing MOLLI T 1 in a clinically relevant range of fat content. J. Magn. Reson. Imaging 2016;44:105–111.

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Liver fat volume fraction quantification with fat and water T1 and T2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

Cited by 28 publications

References 42 publications

Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Simultaneous MR quantification of hepatic fat content, fatty acid composition, transverse relaxation time and magnetic susceptibility for the diagnosis of non‐alcoholic steatohepatitis

Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

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Liver fat volume fraction quantification with fat and water T1 and T2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

Cited by 28 publications

References 42 publications

Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Simultaneous MR quantification of hepatic fat content, fatty acid composition, transverse relaxation time and magnetic susceptibility for the diagnosis of non‐alcoholic steatohepatitis

Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T

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Influence of fat on liver T₁ measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T