Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Weis, Ján; Kullberg, Joel; Åhlström, Håkan

doi:10.1002/jmri.25734

Cited by 21 publications

(53 citation statements)

References 42 publications

(104 reference statements)

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“…A dedicated localized 1 H MRS study on absolute metabolite levels of the liver in 44 middle‐aged subjects reports a tCho value of 8.6 ± 3.1 mmol/kg wet weight (range 3.8–17.6) . A recent similar study arrived at a mean tissue content of tCho in the adult healthy liver of 7.4mM/kg wet weight (range 4.9–10.4) . The variation in tCho content in the adult liver seemed largely due to the increase of this content with age.…”

Section: Discussionmentioning

confidence: 93%

“…It is well known that these times are increased in primary and metastatic tumors, [38][39][40] although there are only few reports of studies at 3 T. In hepatic cancers an average T 2 for the methyl protons in tCho of 133 ms was reported 14 ; this is about twice that of tCho protons in normal healthy liver. 19,29 Water proton T 2 increases about 1.5-to 2-fold in tumor lesions compared with normal liver tissue. 38 From these relaxation times we estimate that the mean tissue levels of tCho of tumorous lesions, using the water signal as a reference at a T E of 30 ms and T 2 values for normal liver, differ by less than 10% from calculations taking T 2 relaxation time for tumorous tissue into account.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, our estimations of tCho content may be affected by differences in T 2 and T 1 proton relaxation times of water or tCho between tumor tissue and normal liver. It is well known that these times are increased in primary and metastatic tumors, although there are only few reports of studies at 3 T. In hepatic cancers an average T 2 for the methyl protons in tCho of 133 ms was reported 14 ; this is about twice that of tCho protons in normal healthy liver . Water proton T 2 increases about 1.5‐ to 2‐fold in tumor lesions compared with normal liver tissue .…”

Section: Discussionmentioning

confidence: 99%

“…19 A recent similar study arrived at a mean tissue content of tCho in the adult healthy liver of 7.4mM/kg wet weight (range 4.9-10.4). 29 The variation in tCho content in the adult liver seemed largely due to the increase of this content with age. In the present study we determined comparable absolute tissue levels and variations thereof for tCho in the normal liver (6.9 mmol/kg wet weight; range 4.9-11.1).…”

Section: Discussionmentioning

confidence: 99%

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Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS

Voert

Heijmen²,

Asten

et al. 2018

NMR in Biomedicine

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Purpose A relatively high signal for choline‐containing compounds (total choline, tCho) is commonly found in 1H MR spectra of malignant tumors, but it is unclear if this also occurs in tumors in the liver. We evaluated the potential of the tCho signal in single voxel 1H MR spectra of the human liver to assess metastases of colorectal cancers. Experiment MR spectra of an 8 cm3 PRESS‐localized voxel were obtained at 3 T from the livers of 12 healthy volunteers and from metastatic lesions in 20 patients in two different sessions. To correct for motion artifacts, sequentially recorded spectra were individually phased and frequency aligned before averaging. Spectra were analyzed using LCModel and tissue levels estimated by water referencing. Repeatability was assessed with Bland–Altman analyses. To estimate tumor necrosis, diffusion‐weighted imaging of the liver was performed. High resolution magic angle spinning (HRMAS) spectra of tumor and normal liver samples were obtained at 11.7 T. Results With increasing tumor volumes, tCho levels decreased, indicating a partial volume effect. Mean tCho content in tumors larger than the PRESS voxel (>8 cm3) was significantly lower (p < 0.01) than for normal liver: 1.6 (range 0.0–3.4) versus 6.9 (range 4.9–11.1) mmol/kg wet weight, while it was comparable for tumors smaller than 8 cm3: 7.0 (range 3.8–9.3) mmol/kg. The higher 90th percentile apparent diffusion coefficient value in the larger lesions indicates more necrosis. Measurement repeatability was average in normal livers and poor in tumors. HRMAS did not show substantial differences in choline‐containing compounds between normal liver and metastasis. Conclusion An increased tCho content was not observed in 1H MR spectra of liver metastasis of colorectal cancer, compared with normal liver. This may be due to the background of a high tCho signal in spectra of normal liver or to an intrinsic lower tCho content in these tumors, but is most likely the result of necrosis in metastatic tumor tissue.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS

Voert

Heijmen²,

Asten

et al. 2018

NMR in Biomedicine

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“…In humans a daily variation of 20 % has been observed by ultra-sound [88]. More recently, Weis et al observed a 50 % reduction in liver glycogen within one day [89] and as glycogen also binds water, this further illustrates the variable hydration of the liver. To compare the hydration effects on PDFF and RFC, lets express PDFF and RFC as V w and V o : 18) and RFC:…”

Section: Fat-referenced Mri and Pdffmentioning

confidence: 96%

Fat-Referenced MRI: Quanitaive MRI for Tissue Characterizaion and Volume Measurement

Romu¹

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ii POPULÄRVETENSKAPLIG SAMMANFATTNING Avvikande eller förändrad kroppssammansättning är centralt del i många av de större utmaningar som vården står inför. Vi blir allt äldre och allt fler drabbas av sarkopeni (förlust av muskelvolym och styrka). Samtidigt ökar andelen av befolkningen som lider av fetma (ett BMI över 30), vilket för med sig en ökad risk för bland annat typ 2 diabetes, hjärt-och kärlsjukdomar samt vissa sorters cancer. På befolkningsnivå ses starka samband mellan BMI risk för sjukdom, men BMI räcker ofta inte till för att precist avgöra en individs risk för specifika sjukdomar.Aktuell forskning har visat att fettets fördelning i kroppen, och hur fett lagras in i olika organ så som levern, kan ge en bättre förståelse om den individuella risken för sjukdom och dödlighet. Ett tydligt exempel är att en person med bukfetma har en större risk för metabola sjukdomar, jämfört med en som primärt lagrar fett under huden. Två personer med samma mängd fett kan alltså ha två olika riskprofiler. Problemet är att det finns få kliniska verktyg för att göra noggranna och detaljerade mätningar av fettfördelningen inuti kroppen. De som finns är antingen indirekta, opraktiska eller kräver ingrepp så som biopsier. Mer precisa mätinstrument skulle ge vården möjlighet att säkrare bedöma vilka specifika risker en individ står inför, hur en behandling påverkar kroppen och skräddarsy behandlingen därefter.Magnetisk resonanstomografi (MRT) anses av många vara den mest noggranna metoden för att mäta hur fett och andra vävnader är fördelade i kroppen. Kroppssammansättning mäts oftast genom att en operatör definierar vad som är vad i MRT-bilderna, och sedan beräknas volymen av varje område. För fettmätning innebär det att en operatör måste välja vilka delar av bilderna som består av fettvävnad och vilka som inte gör det. Bättre vore om bilden var kvantitativ, så att dess intensitet avspeglade mängden fettvävnad. Med sådana bilder behöver operatören endast definiera vilket område som det skall mätas fettvävnad inom. En sådan uppgift är både mer tidseffektiv och enklare att automatisera.I den här avhandlingen presenteras hur en kvantitativ MRT-metod kallad fett-refererad MRT kan implementeras i praktiken. Fett-refererad MRT skapar en bild utav allt fett i kroppen, där alla bildvärden representerar andelen fettvävnad. Avhandlingen visar att metoden är okänslig för den ursprungliga kontrasten i bilderna som fett-refererad MRT använder som indata, vilket gör det troligt att fett-refererad MRT kommer mäta samma kroppskomposition, oavsett MRTkamera.Avhandlingen undersöker också om fett-refererad MRT kan användas för att mäta brunt fett. Till skillnad från vitt fett, som lagrar energi, så förbränner brunt fett energi för att generera värme. Det bruna fettet har med andra ord en unik funktion i kroppen, och dess påverkan på metabolismen och sjuklighet studeras för närvarande flitigt. De högupplösta och kvantitativa bilder som den fett-refererade metoden genererar visade sig lämpliga för brun fettmätning i råtta. Metoden användes sedan...

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Single‐voxel short‐TR multi‐TI multi‐TE STEAM MRS for water–fat relaxometry

Ruschke

Karampinos

2022

Magnetic Resonance in Med

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Purpose To propose a short‐TR multi‐TI multi‐TE (SHORTIE, [ˈshȯr‐tē]) STEAM single‐voxel MRS acquisition scheme for the simultaneous assessment of T1 relaxation, T2 relaxation, and the proton density fat fraction at reduced scan times when compared with conventional long‐TR multi‐TI STEAM and long‐TR multi‐TE STEAM single‐voxel MRS. Methods Theoretical analysis for multi‐TI (TI = 10, 100, 500, 1500 ms; scan time = 2:43 minutes), multi‐TE (TE = 12, 15, 20, 25 ms; scan time = 2:24 minutes), and SHORTIE STEAM (all TI and TE combinations; scan time = 2:52 minutes) was carried out including Cramér‐Rao lower bound and parameter estimation efficiency analysis for T1 (150–2000 ms) and T2 (5–150 ms) relaxation. The SHORTIE STEAM acquisition was compared with multi‐TI STEAM and multi‐TE STEAM in water–fat phantoms and in a human in vivo study of the adipose tissue depot in the supraclavicular fossa in 7 volunteers at 3 T. Results Cramér‐Rao lower bound analysis revealed similar to increased variances for T1 and T2 estimators for SHORTIE STEAM. Parameter efficiency analysis demonstrated superior performance of SHORTIE, particularly for shorter T1 and T2 when compared with multi‐TI STEAM and multi‐TE STEAM. For the phantom data, linear regression and Bland‐Altmann analysis yielded a slope/intercept/mean difference of 1.07/−15.40/−17.18 for T1 (in ms; r = 0.999), 0.93/+1.32/+1.09 for T2 (in ms; r = 0.995), and 0.98/−0.04/+0.78 for the fat fraction (in percent; r = 0.999); and for the in vivo data 1.08/+1.77/−62.2 for T1 (r = 0.994), 0.88/+6.69/−1.55 for T2 (r = 0.884), and 0.56/+34.40/−0.46 for the fat fraction (r = 0.673), respectively. Conclusion The SHORTIE STEAM acquisition allows shorter scan times for the simultaneous probing of relaxation properties and spectral content in the water–fat environment when compared with combined long‐TR multi‐TI, and long‐TR multi‐TE STEAM.

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Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Abstract: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:410-417.

Cited by 21 publications

References 42 publications

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS

Fat-Referenced MRI: Quanitaive MRI for Tissue Characterizaion and Volume Measurement

Single‐voxel short‐TR multi‐TI multi‐TE STEAM MRS for water–fat relaxometry

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Multiple breath‐hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

Abstract: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:410-417.

Cited by 21 publications

References 42 publications

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by 1H MRS

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by 1H MRS

Fat-Referenced MRI: Quanitaive MRI for Tissue Characterizaion and Volume Measurement

Single‐voxel short‐TR multi‐TI multi‐TE STEAM MRS for water–fat relaxometry

Contact Info

Product

Resources

About

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS

Levels of choline‐containing compounds in normal liver and liver metastases of colorectal cancer as recorded by ¹H MRS