Liver diseases in Mexico and their associated mortality trends from 2000 to 2007: A retrospective study of the nation and the federal states

Méndez-Sánchez, Nahúm; García-Villegas, Elsy Aidé; Merino-Zeferino, Beatriz; Ochoa-Cruz, Soledad; Villa, Antonio; Madrigal, Herlinda; Kobashi-Margáin, Ramón A.; Gutiérrez-Grobe, Ylse; Chávez-Tapia, Norberto C.; Ponciano-Rodríguez, Guadalupe; Uribe, Misael

doi:10.1016/s1665-2681(19)31619-9

Cited by 26 publications

(15 citation statements)

References 22 publications

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“…In terms of risk factors, high rates of abdominal obesity, overweight and obesity, as well as elevated alcohol consumption were found in both study populations. These results are consistent with other studies that report a high prevalence of obesity and heavy alcohol consumption among Mexican Americans in the US [35] and Mexico [36,37].…”

Section: Discussionsupporting

confidence: 93%

Risk Factors for Liver Disease and Associated Knowledge and Practices Among Mexican Adults in the US and Mexico

et al. 2011

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Latinos in the US are disproportionately affected by chronic liver disease, which is the sixth most common cause of death among this group. In Mexico, cirrhosis and other liver diseases are the fourth leading cause of general mortality. The objective of this study was to contrast the liver disease risk factors, knowledge, and prevention practices reported among separate samples of Mexicans living in Los Angeles, CA and in Cuernavaca, Mexico. We assessed the prevalence of specific risk factors (body mass index, waist circumference, and alcohol consumption), the level of knowledge about liver disease in general, hepatitis B (HBV), and hepatitis C (HCV), as well as prevention activities such as screening and vaccination. Data were collected from in-person interviews and anthropometric measures obtained from Mexican adults aged 18-70 years. Chi-square and t tests were used to compare the results between groups. Numerous similarities were observed in the bi-national samples, including high prevalence of obesity, abdominal obesity, and high levels of alcohol consumption. Most participants in both countries recognized that excessive alcohol consumption is a risk factor for liver disease, but only 60% correctly identified hepatitis C, being overweight or obese, or having diabetes as risk factors. Few participants reported having been screened for HBV or HCV, vaccinated for HBV, or having the intention of getting screened for HBV or HCV. US participants reported significantly higher levels of prevention activities and screening intentions than those in Mexico. Identifying the specific risk factors, levels of knowledge and prevention activities that affect specific racial/ethnic populations is important in order to effectively target efforts to prevent liver disease.

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Section: Discussionsupporting

confidence: 93%

Risk Factors for Liver Disease and Associated Knowledge and Practices Among Mexican Adults in the US and Mexico

et al. 2011

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“…Mexican physicians have been active in the analysis and quantification of the burden of HCV disease. The majority of infections in Mexico are due to previous transfusion, and it is well known that disease, mortality and cost related to chronic HCV infection are increasing as the population ages . In a study of the aetiology of liver cirrhosis, HCV was attributed in 37% of cases .…”

Section: Discussionmentioning

confidence: 99%

Strategies to manage hepatitis C virus (HCV) infection disease burden – volume 2

Gane

Kershenobich

Seguin-Devaux

et al. 2015

Journal of Viral Hepatitis

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SUMMARY. The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries, and the relative impact of two scenarios was considered: (i) increased treatment efficacy while holding the treated population constant and (ii) increased treatment efficacy and increased annual treated population. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. In most countries, the annual treated population had to increase several fold to achieve the largest reductions in HCV-related morbidity and mortality. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. In most of the studied countries, the majority of patients were born between 1945 and 1985.

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“…Changes in human habits tend to increase the prevalence of severe liver diseases, such as steatohepatitis, cirrhosis, viral hepatitis and liver cancer [1].…”

Section: Introductionmentioning

confidence: 99%

GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion

Gerardo-Ramírez

Lazzarini‐Lechuga

Hernández-Rizo

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features, despite some controversies in age-related studies. GDF11 has been poorly investigated in cancer, particularly in those with stemness capacity, such as hepatocellular carcinoma (HCC), one of the most aggressive cancers worldwide. Here, we focused on investigating the effects of GDF11 in liver cancer cells. GDF11 treatment significantly reduced proliferation, colony and spheroid formation in HCC cell lines. Consistently, down-regulation of CDK6, cyclin D1, cyclin A, and concomitant upregulation of p27 was observed after 24 h of treatment.Interestingly, cell viability was unchanged, but cell functionality was compromised. These effects were potentially induced by the expression of Ecadherin and Occludin, as well as Snail and N-cadherin repression, in a timedependent manner. Furthermore, GDF11 treatment for 72 h induced that cells were incapable of sustaining colony and sphere capacity in the absent of GDF11, up to 5 days, indicating that the effect of GDF11 on self-renewal capacity is not transient. Finally, in vivo invasion studies revealed a significant decrease in cell migration of hepatocellular carcinoma cells treated with GDF11 associated to a decreased proliferation judged by Ki67 staining. Data show that exogenous GDF11 displays tumor suppressor properties in HCC cells.

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Liver diseases in Mexico and their associated mortality trends from 2000 to 2007: A retrospective study of the nation and the federal states

Cited by 26 publications

References 22 publications

Risk Factors for Liver Disease and Associated Knowledge and Practices Among Mexican Adults in the US and Mexico

Risk Factors for Liver Disease and Associated Knowledge and Practices Among Mexican Adults in the US and Mexico

Strategies to manage hepatitis C virus (HCV) infection disease burden – volume 2

GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion

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