Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol

Salmon‐Céron, Dominique; Lewden, Charlotte; Morlat, Philippe; Bévilacqua, Sibylle; Jougla, Éric; Bonnet, Fabrice; Héripret, Laurence; Costagliola, Dominique; May, Thierry; Chêne, Geneviève

doi:10.1016/j.jhep.2005.01.022

Cited by 290 publications

(172 citation statements)

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“…In recent years, end stage liver disease has become a major cause of morbidity and mortality in patients chronically infected with the Human Immunodeficiency Virus (HIV) who are coinfected with hepatitis C (HCV) or B virus (HBV) (1)(2)(3)(4). This trend may be explained by a prolonged exposure to viral hepatitis, because most patients were infected with HCV in the 1980s.…”

Section: Introductionmentioning

confidence: 99%

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Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study

Salmon‐Céron

Rosenthal

Lewden

et al. 2009

Journal of Hepatology

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104

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Section: Introductionmentioning

confidence: 99%

“…Several studies including the French national survey, "Mortalité 2000", have shown that complications of HCV and HBV are the second most frequent underlying cause of death after AIDS in HIV-infected patients, accounting for around 10% of deaths (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study

Salmon‐Céron

Rosenthal

Lewden

et al. 2009

Journal of Hepatology

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104

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“…In addition, HIV infection increases the risk of chronic HBV infection and promotes a faster progression to cirrhosis and its complications, particularly when HBV replication is high [9][10][11] .…”

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The prevalence of hepatitis B virus infection markers and socio-demographic risk factors in HIV-infected patients in Southern Brazil

Martins

Livramento

Andrigueti

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…From 1995 to 2010, the proportion of AIDS-related deaths in this survey of HIVinfected adults decreased from 92% to 20% of all causes of death. Over this period of time, the proportion of liverrelated deaths dramatically increased (11-fold higher) during the first decade and LRDs were a leading cause of mortality [5][6][7][8]20], as shown in other European and US studies [21][22][23], and were ranked first as a cause of mortality in HCV/HIV-infected individuals [18]. In 2010, the curve appeared to flatten out, LRDs representing the second most frequent non-AIDS-related cause of death in this population, as recently reported in the Swiss HIV Cohort Study [24].…”

Section: Discussionmentioning

confidence: 99%

Liver‐related deaths in HIV‐infected patients between 1995 and 2010 in France: the Mortavic 2010 study in collaboration with the Agence Nationale de Recherche sur le SIDA (ANRS) EN 20 Mortalité 2010 survey

et al. 2014

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ObjectivesThe aim of this study was to describe the proportion of liver-related diseases (LRDs) as a cause of death in HIV-infected patients in France and to compare the results with data from our five previous surveys. MethodsIn 2010, 24 clinical wards prospectively recorded all deaths occurring in around 26 000 HIV-infected patients who were regularly followed up. Results were compared with those of previous cross-sectional surveys conducted since 1995 using the same design. ResultsAmong 230 reported deaths, 46 (20%) were related to AIDS and 30 (13%) to chronic liver diseases. Eighty per cent of patients who died from LRDs had chronic hepatitis C, 16.7% of them being coinfected with hepatitis B virus (HBV). Among patients who died from an LRD, excessive alcohol consumption was reported in 41%. At death, 80% of patients had undetectable HIV viral load and the median CD4 cell count was 349 cells/μL. The proportion of deaths and the mortality rate attributable to LRDs significantly increased between 1995 and 2005 from 1.5% to 16.7% and from 1.2‰ to 2.0‰, respectively, whereas they tended to decrease in 2010 to 13% and 1.1‰, respectively. Among liver-related causes of death, the proportion represented by hepatocellular carcinoma (HCC) dramatically increased from 5% in 1995 to 40% in 2010 (p = 0.019). ConclusionsThe proportion of LRDs among causes of death in HIV-infected patients seems recently to have reached a plateau after a rapid increase during the decade 1995−2005. LRDs remain a leading IntroductionAs a consequence of shared transmission routes, HIVinfected persons are at risk of other blood-borne and sexually transmitted infections. Hepatitis C virus (HCV) infection, which is predominantly transmitted parenterally, is common in this group. In northern countries, since the mid-1990s, several developments, such as the widespread use of combination antiretroviral therapy (cART) and better access to treatment for chronic hepatitis C, have contributed (1) to modifications of the natural history of chronic HCV infection in HIV-infected persons, and (2) to the emergence of liver-related diseases (LRDs) as a significant cause of mortality among coinfected individuals [1][2][3][4]. During the first decade following the advent of cART (1995−2005), the proportion of deaths attributable to LRDs in French HIV-infected patients has progressively increased and LRDs have become a leading cause of mortality [5][6][7][8]. This is likely to have been related to prolonged longevity as a result of decreasing AIDS-related mortality and longer exposure to chronic HCV infection. In parallel, large trials have demonstrated that HIV/HCV-coinfected patients may achieve a sustained virological response with combined treatment with pegylated interferon plus ribavirin, leading to histopathological improvement [9,10]. Continuing efforts to educate physicians and patients increased the access of HIV/HCV-coinfected patients to HCV treatment [11,12]. Finally, the eradication of HCV after therapy in HIV/HCV-coinfected patients is associate...

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Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol

Cited by 290 publications

References 26 publications

Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study

Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study

The prevalence of hepatitis B virus infection markers and socio-demographic risk factors in HIV-infected patients in Southern Brazil

Liver‐related deaths in HIV‐infected patients between 1995 and 2010 in France: the Mortavic 2010 study in collaboration with the Agence Nationale de Recherche sur le SIDA (ANRS) EN 20 Mortalité 2010 survey

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