The prevalence of hepatitis B virus infection markers and socio-demographic risk factors in HIV-infected patients in Southern Brazil

Martins, Saulo; Livramento, Andréa do; Andrigueti, Michelle; Kretzer, Iara Fabrícia; Machado, Marcos José; Spada, Celso; Treitinger, Arício

doi:10.1590/0037-8682-0109-2014

Cited by 17 publications

(13 citation statements)

References 35 publications

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“…Infection with HIV, HBV, and HCV share the same routes of transmission, especially sexual and vertical for HIV and HBV, and parenteral for HIV and HCV [Alter, ]. The prevalence of anti‐HBc in HIV‐infected patients (without TB) varies in the literature of 26.2–38.6% [Mendes‐Corrêa et al, ; Freitas et al, ; Martins et al, ]. It is worth noting that the prevalence rate observed in our study in patients co‐infected with HIV/TB were within the limits above described and very close to that found (38.6%) by Mendes‐Corrêa et al, [] in patients HIV monoinfected.…”

Section: Discussionsupporting

confidence: 75%

Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Araújo-Mariz

Lopes

Ximenes

et al. 2015

Journal of Medical Virology

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Infection with hepatitis B virus (HBV) and C virus (HCV) are common in patients with HIV/AIDS and tuberculosis (TB). This is a cross-sectional study with patients infected with HIV/AIDS and active TB in Recife, Brazil, aiming to verify the prevalence of markers for HBV: antibody to hepatitis B core antigen (anti-HBc); and HCV: antibody to hepatitis C virus (anti-HCV) by chemiluminescence, and to identify the frequency of associated factors. Data were collected through questionnaires, and blood was drawn from patients for analysis. We used the chi-square test and the Fisher exact test when necessary. We conducted a bivariate logistic regression analysis and the magnitude of the associations was expressed as odds ratio (OR) with a confidence interval of 95%. Among 166 patients studied with HIV/AIDS and active TB, anti-HBc was positive in 61 patients [36.7%; 95%CI (29.4-44.6%)] and anti-HCV in 11[6.6%; 95%CI (3.4-11.5%)]. In the logistic regression analysis, male sex, and age ≥40 years were independent factors associated with the occurrence of anti-HBc. In conclusion, we verified a high frequency of HBV contact marker and a low frequency of HCV markers in patients with HIV/AIDS and TB in Recife.

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Section: Discussionsupporting

confidence: 75%

Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Araújo-Mariz

Lopes

Ximenes

et al. 2015

Journal of Medical Virology

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“…(15) Anti-HBc was detected in 29.20% and 27.3% of HIV infected patients in Nigeria and Brazil respectively. (17,16) Anti-HBc was the sole HBV marker in 35 (17.77%) HIV patients, which is close to 17.50% (71 out of 405) and the 16% (38 out of 240) reported in Italy and Boston, respectively. (18,19) Isolated anti-HBc was detected in 12.7% in the study carried out by Aly (15) However, this percent is lower than what has been described in previous studies of HIV-positive patients, namely; the 26.80% detected in India, (20) and the 28.30% in Taiwan.…”

Section: Discussionsupporting

confidence: 61%

“…In a Brazilian study, HBsAg has been reported to be the sole HBV marker in one (0.3%) HIV-patient. (16) Possibilities include recent infection, acute infection or remote past infection with undetectable other markers. Out of those with sole HBsAg marker, only one patient was vaccinated.…”

Section: Discussionmentioning

confidence: 99%

Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc

Abdelaziz

Fekry

Hashish

2019

Journal of High Institute of Public Health

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Background :Occult hepatitis B infection (OBI), defined as the presence of hepatitis B virus (HBV) DNA in liver or serum despite the absence of detectable hepatitis B surface antigen (HBsAg) is a frequent contaminant with human immunodeficiency virus (HIV). HIV has a negative effect on HBV disease accelerating its natural course. Objective: This study aimed to estimate the occurrence of OBI in Egyptian HIV-infected patients with isolated anti-HBc. Methods: This cross-sectional study was conducted on 197 HIV infected patients. They were tested for HBsAg, Antibody to hepatitis B surface antigen (anti-HBs), antibody to HBV core antigen (anti-HBc), and CD4 count. Patients with sole anti-HBc were screened for HBV DNA by polymerase chain reaction (PCR). Results: Among those patients, 13 (6.60%) were positive for HBsAg, 82 (41.62%) for anti-HBc and 70 (35.53%) for anti-HBs. Their corresponding median CD4 count was 310.00 cells/mm 3 , 497.50 cells/mm 3 and 525.50 cells/mm 3 , respectively. Anti-HBc was the sole marker in 35 (17.77%) patients of whom 7 (20%) were HBV DNA positive indicating OBI. Most OBI patients were non-vaccinated against HBV. There was no significant statistical relationship between the presence of OBI and CD4 count, although most of them had CD4 count less than 500 cells/mm 3 . Conclusion: The present study underscores the importance of OBI screening among HIV patients with isolated anti-HBc.

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“…It is estimated that approximately 7.4% of PLWH are chronically HBV infected; conversely, about 1% of those with chronic HBV infection are HIV infected [14]. Coinfection rates are geographically heterogeneous and vary from 5% to up to 20% worldwide, depending on various factors such as distribution of risk groups, implementation of HBV vaccination programs, and levels of endemicity in the general population [15][16][17]. The highest rates are found in Asia and Africa [18], primarily affecting vulnerable populations of low-/middle-income countries [19].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey

et al. 2020

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Background Coinfections of HIV patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) are mayor public health problems, contributing to the emerging burden of HIV-associated hepatic mortality. Coinfection rates vary geographically, depending on various factors such as predominant transmission modes, HBV vaccination rates, and prevalence of HBV and HCV in the general population. In South America, the epidemiology of coinfections is uncertain, since systematic studies are scarce. Our study aimed to analyze rates of HBV and HCV infection in people living with HIV attending centers of the public and private health system in Chile. Methods We performed a cross-sectional study including a public university hospital and a private health center in Santiago, Metropolitan Region in Chile. Serum samples were used to determine serological markers of hepatitis B (HBsAg, anti-HBs, anti-HBc total, HBeAg, anti-HBe) and anti-HCV. Demographic, clinical and laboratory data were obtained from medical records. Results 399 patients were included (353 from public, 46 from private health center). Most (92.8%) were male, with a median age of 38.3 years; 99.4% acquired HIV through sexual contact

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The prevalence of hepatitis B virus infection markers and socio-demographic risk factors in HIV-infected patients in Southern Brazil

Cited by 17 publications

References 35 publications

Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc

Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey

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