Liver Cancer Ablation with
Extracorporeal High-Intensity
Focused Ultrasound

Yang, Rong; Sanghvi, Narendra T.; Rescorla, Frederick J.; Kopecky, Kenyon K.; Grosfeld, Jay L.

doi:10.1159/000474674

Cited by 69 publications

(30 citation statements)

References 11 publications

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“…The earliest reported clinical use of HIFU was for treatment of Parkinson's disease (Fry et al 1954). Clinical applications include treatment of renal tumors (Wu et al 2003b;Marberger et al 2005;Kohrmann et al 2002), prostate cancer Thuroff et al 2003;Blana et al 2004), liver cancer (ter Haar et al 1989;Yang et al 1993;Kennedy et al 2004) and breast cancer (Wu et al 2003aGianfelice et al 2004), among others. In the 1980's our research group used HIFU for treatment of glaucoma (Coleman et al 1985;Burgess et al 1986;Silverman et al 1991) and ocular tumors Coleman et al 1986).…”

Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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Spectral parameter imaging in both the fundamental and harmonic of backscattered radiofrequency (RF) data was used for immediate visualization of high-intensity focused ultrasound (HIFU) lesion sites. A focused 5-MHz HIFU transducer with a coaxial 9-MHz focused single-element diagnostic transducer was used to create and scan lesions in chicken breast and freshly excised rabbit liver. Bmode images derived from the backscattered RF signal envelope were compared with midband fit (MBF) spectral parameter images in the fundamental (9-MHz) and harmonic (18-MHz) bands of the diagnostic probe. Images of HIFU-induced lesions derived from the MBF to the calibrated spectrum showed improved contrast (~ 3 dB) of tumor margins versus surround compared to images produced from the conventional signal envelope. MBF parameter images produced from the harmonic band showed higher contrast in attenuated structures (core, shadow) compared to either the conventional envelope (3.3 dB core; 11.6 dB shadow) or MBF images of the fundamental band (4.4 dB core; 7.4 dB shadow). The gradient between the lesion and surround was 3.4 dB/mm, 6.9 dB/mm and 17.2 dB/mm for B-mode, MBF-fundamental mode and MBF-harmonic mode respectively. Images of threshold and 'popcorn' lesions produced in freshly excised rabbit liver were most easily visualized and boundaries best defined using MBF-harmonic mode.

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Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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“…In 1956, Burov proposed that effect of short-time high-intensity ultrasound irradiation was better than low-intensity ultrasound. With research progress on HIFU technology, this technology has been used in clinic over the years [3][4][5][6] . The present study makes an assessment on clinic effect of HIFU in treating liver cancer.…”

Section: Introductionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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AIM:To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment. RESULTS:After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95±44) U/L and AST (114±58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

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“…Several studies have examined the histological changes related to therapeutic ultrasound ablation in various tissues [20,19,21,22,18,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance

et al. 2012

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent repository link a b s t r a c tThe aim of this study was to evaluate a flat rectangular (3 Â 10 mm 2 ) MRI compatible transducer operating at 5 MHz. The main task was to explore the feasibility of creating deep lesions in heart at a depth of at least 15 mm. The size of thermal necrosis in heart tissue was estimated as a function of power and time using a simulation model. The system was then tested in an excised lamb heart. In this study, we were able to create lesions of 15 mm deep with acoustic power of 6 W for an exposure of approximately 1 min. The contrast to noise ratio (CNR) between lesion and heart tissue was evaluated using fast spin echo (FSE). The CNR value was approximately 22 using T1 W FSE. Maximum CNR was achieved with repetition time (TR) between 300 and 800 ms. Using T2W FSE, the corresponding CNR was approximately 13 for the 14 in vivo experiments. The average lesion depth was 11.93 mm with a standard deviation of 0.62 mm. In vivo irradiation conditions were 6 W for 60 s. The size of the lesion in the other two dimensions was close to 3 Â 10 mm 2 (size of the transducer element).

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Liver Cancer Ablation with Extracorporeal High-Intensity Focused Ultrasound

Cited by 69 publications

References 11 publications

Improved visualization of high-intensity focused ultrasound lesions

Improved visualization of high-intensity focused ultrasound lesions

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance

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