Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance

Couppis, Andreas; Damianou, Christakis; Kyriacou, Panayiotis A.; Lafon, Cyril; Chavrier, F.; Chapelon, Jean‐Yves; Birer, Alain

doi:10.1016/j.ultras.2012.03.010

Cited by 8 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, transesophageal devices have been designed for targeted ablation of the left atrium for treatment of atrial fibrillation (Figure 2d). Some recent studies include in vivo swine models with atrial and ventricular myocardial ablations [72], ex vivo pig hearts [63, 64, 86], and simulation and device design [68-70]. …”

Section: Endoluminal Cbusmentioning

confidence: 99%

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Salgaonkar

Diederich

2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

Catheter-based ultrasound (CBUS) is being applied to deliver minimally invasive thermal therapy to solid cancer tumors, benign tissue growth, vascular disease, and tissue remodeling. Compared to other energy modalities used in catheter-based surgical interventions, unique features of ultrasound result in conformable and precise energy delivery with high selectivity, fast treatment times, and larger treatment volumes. Here, a concise review of CBUS technology being currently utilized in animal and clinical studies or being developed for future applications is presented. CBUS devices have been categorized into interstitial, endoluminal and endovascular/cardiac applications. Basic applicator designs, site specific evaluations and possible treatment applications have been discussed in brief. Particular emphasis has been given on ablation studies that incorporate image-guidance for applicator placement, therapy monitoring, feedback control, and post-procedure assessment. Examples of devices included here span the entire spectrum of development cycle from preliminary simulation based design studies to implementation in clinical investigations. The use of CBUS under image guidance has the potential for significantly improving precision and applicability of thermal therapy delivery.

show abstract

Section: Endoluminal Cbusmentioning

confidence: 99%

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Salgaonkar

Diederich

2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…Majority of the development has occurred for endocardial applications for treating atrial fibrillation 10,12,13 . Devices have also been developed for transesophageal cardiac ablation [14][15][16][17] . Clinical translation of ultrasound ablation catheters has thus far been limited by high rates of esophageal-atrial fistulas, potentially due to the depth of penetration of ultrasound energy 18 .…”

Section: Introductionmentioning

confidence: 99%

Catheter-based high-intensity ultrasound for epicardial ablation of the left ventricle: device design andin vivofeasiblity

Salgaonkar

Nazer

Jones

et al. 2015

Energy-Based Treatment of Tissue and Assessment VIII

View full text Add to dashboard Cite

The development and in vivo testing of a high-intensity ultrasound thermal ablation catheter for epicardial ablation of the left ventricle (LV) is presented. Scar tissue can occur in the mid-myocardial and epicardial space in patients with nonischemic cardiomyopathy and lead to ventricular tachycardia. Current ablation technology uses radiofrequency energy, which is limited epicardially by the presence of coronary vessels, phrenic nerves, and fat. Ultrasound energy can be precisely directed to deliver targeted deep epicardial ablation while sparing intervening epicardial nerve and vessels.The proof-of-concept ultrasound applicators were designed for sub-xyphoid access to the pericardial space through a steerable 14-Fr sheath. The catheter consists of two rectangular planar transducers, for therapy (6.4 MHz) and imaging (5 MHz), mounted at the tip of a 3.5-mm flexible nylon catheter coupled and encapsulated within a custom-shaped balloon for cooling.Thermal lesions were created in the LV in a swine (n = 10) model in vivo. The ultrasound applicator was positioned fluoroscopically. Its orientation and contact with the LV were verified using A-mode imaging and a radio-opaque marker. Ablations employed 60-s exposures at 15 -30 W (electrical power). Histology indicated thermal coagulation and ablative lesions penetrating 8 -12 mm into the left ventricle on lateral and anterior walls and along the left anterior descending artery.The transducer design enabled successful sparing from the epicardial surface to 2 -4 mm of intervening ventricle tissue and epicardial fat. The feasibility of targeted epicardial ablation with catheter-based ultrasound was demonstrated.

show abstract

HIFU Tissue Ablation: Concept and Devices

Haar

2016

Advances in Experimental Medicine and Biology

102

View full text Add to dashboard Cite

High intensity focused ultrasound (HIFU) is rapidly gaining clinical acceptance as a technique capable of providing non-invasive heating and ablation for a wide range of applications. Usually requiring only a single session, treatments are often conducted as day case procedures, with the patient either fully conscious, lightly sedated or under light general anesthesia. HIFU scores over other thermal ablation techniques because of the lack of necessity for the transcutaneous insertion of probes into the target tissue. Sources placed either outside the body (for treatment of tumors or abnormalities of the liver, kidney, breast, uterus, pancreas brain and bone), or in the rectum (for treatment of the prostate), provide rapid heating of a target tissue volume, the highly focused nature of the field leaving tissue in the ultrasound propagation path relatively unaffected. Numerous extra-corporeal, transrectal and interstitial devices have been designed to optimize application-specific treatment delivery for the wide-ranging areas of application that are now being explored with HIFU. Their principle of operation is described here, and an overview of their design principles is given.

show abstract

Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance

Cited by 8 publications

References 59 publications

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

Catheter-based high-intensity ultrasound for epicardial ablation of the left ventricle: device design andin vivofeasiblity

HIFU Tissue Ablation: Concept and Devices

Contact Info

Product

Resources

About