Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years

Uzelac, P.S.; Delaney, Abigail A.; Christensen, Greg L.; Bohler, Henry; Nakajima, Steven T.

doi:10.1016/j.fertnstert.2015.07.1148

Cited by 83 publications

(63 citation statements)

References 7 publications

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“…The use of neoadjuvant chemotherapy has increased in recent years, so it is also necessary to consider treatment for patients with no time delay. Controlled ovarian stimulation is costly and time‐consuming and thus it is unacceptable for some patients . Recently, OTC has been considered for patients with breast cancer who are undergoing neoadjuvant chemotherapy and strongly desire FP .…”

Section: Methods Of Fertility Preservationmentioning

confidence: 99%

“…Similarly, in 2014, the first live birth due to FP was reported for a patient with a borderline ovarian tumor . Live births also have been achieved by using the IVM of immature oocytes that were obtained from resected ovaries . Immature oocytes usually are collected from the ovarian cortex, although the recently reported collection of immature oocytes from the ovarian medulla has the potential as an add‐on method of FP .…”

Section: In Vitro Maturation Of Oocytes Collected In Vivo or Ex Vivomentioning

confidence: 99%

“…It is necessary to explain to patients the current limitations and the necessity for future research. Fertility preservation, including OTC, is expensive and the burden on patients is large . It is also desirable to explain the likelihood of a live birth from FP that the patient can reasonably expect at the present time.…”

Section: Explanation To Patientsmentioning

confidence: 99%

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In vitro maturation of human immature oocytes for fertility preservation and research material

Shirasawa

Terada

2017

Reprod Medicine & Biology

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AimIn recent years, the importance of fertility preservation (FP) has increased. In vitro maturation (IVM), an important technique in FP, has started to be used in the clinic, but controversies persist regarding this technique. Here, a survey of IVM for FP is provided.MethodsBased on a literature review, the applications of FP, methods of FP, IVM of oocytes that had been collected in vivo and ex vivo, maturation of oocytes after IVM for FP, cryopreservation of oocytes for FP, explanation of the procedures to patients, and recent research on FP using IVM were investigated.ResultsAlthough IVM for FP remains controversial, the application of FP is expected to expand. Depending on the age and disease status of the patient, various methods of oocyte collection and ovarian stimulation, as well as various needle types and aspiration pressures, have been reported. The maturation rate of IVM in FP ranges widely and requires optimization in the future. In regard to cryopreservation for matured oocytes, the vitrification method is currently recommended.ConclusionRegarding FP for patients with cancer, the treatment of cancer is prioritized; thus, the time and use of medicines are often constrained. As several key points regarding IVM remain unclear, well‐designed and specific counseling for patients is necessary.

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Section: Methods Of Fertility Preservationmentioning

confidence: 99%

Section: In Vitro Maturation Of Oocytes Collected In Vivo or Ex Vivomentioning

confidence: 99%

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In vitro maturation of human immature oocytes for fertility preservation and research material

Shirasawa

Terada

2017

Reprod Medicine & Biology

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“…However, IVM creates another opportunity for oocyte cryopreservation without ovarian stimulation, especially in those girls undergoing ovarian tissue harvesting for cryopreservation. Yet, the pregnancy potential of in vitro matured oocytes from harvested ovarian tissue remain poorly established even though 2 live births have recently been reported in cancer patients (38,39).…”

Section: In Vitro Maturation Of Oocytesmentioning

confidence: 99%

Fertility preservation in Turner syndrome

Grynberg

Bidet

Benard

et al. 2016

Fertility and Sterility

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“…Mature eggs derived from IVM can be cryopreserved or fertilized and then cryopreserved as embryos. In vitro maturation (IVM) is another promising fertility preservation option, and importantly, pregnancies and live births have been obtained using this method (Chian, et al 2013, Guzman, et al 2012, Segers, et al 2015, Uzelac, et al 2015). …”

Section: Effect Of Ovarian Tissue Transport On Oocytes From Antral Fomentioning

confidence: 99%

Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice

et al. 2016

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Primordial follicles dictate a female’s reproductive lifespan and therefore are central to fertility preservation for both endangered species as well as for individuals with fertility threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue – especially in larger countries or low resource settings. Here we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 hours prior to cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.

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Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years

Cited by 83 publications

References 7 publications

In vitro maturation of human immature oocytes for fertility preservation and research material

In vitro maturation of human immature oocytes for fertility preservation and research material

Fertility preservation in Turner syndrome

Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice

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