Fertility preservation in Turner syndrome

Grynberg, Michaël; Bidet, Maud; Benard, Julie; Poulain, Marine; Sonigo, Charlotte; Cédrin‐Durnerin, Isabelle; Polak, Michel

doi:10.1016/j.fertnstert.2015.11.042

Cited by 79 publications

(93 citation statements)

References 86 publications

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“…This implies that utilization of PBNT may significantly improve ART outcomes and pregnancy rates, particularly for women of advanced age with decreased ovarian reserve. However, this therapy is based on availability of patient PB1, and therefore, is not applicable for women who cannot produce mature oocytes (Bilgin and Kovanci, 2015;Grynberg et al, 2016). Moreover, PBNT technology will be limited to countries, such as the United States, where IVF programs are allowed to coordinate oocyte donation cycles with compensation of donors.…”

Section: Discussionmentioning

confidence: 99%

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

O’Neil

Gutiérrez

et al. 2017

Cell Stem Cell

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Section: Discussionmentioning

confidence: 99%

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

O’Neil

Gutiérrez

et al. 2017

Cell Stem Cell

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“…Although substantial evidence to support OTCP effectiveness has accumulated in recent years [3][4][5], the technique is still considered experimental [6]. The increased awareness and experience utilizing these technologies has led to the acceptance of new indications for FPT, such as genetically related risk for POF or other medical conditions, which considerably limit time available for conception [7,8].…”

Section: Introductionmentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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“…12 A gestação per se impõe um aumento de estresse na aorta, pois mesmo mulheres multíparas normais têm dilatação da aorta ascendente quando comparadas ao grupo controle da mesma 13 Devido a anomalias cardiovasculares inerentes associadas a ST, essas mulheres estão em maior risco de morrer por dissecção/ruptura da aorta e têm risco elevado de hipertensão induzida pela gravidez, pré-eclâmpsia, da gestação ou no puerpério e em gestações múltiplas, que podem ocorrer por reprodução assistida.…”

Section: Discussionunclassified

“…13 A adoção deve ser considerada como uma alternativa para aquelas que almejam a maternidade. 12 A equipe deve proporcionar àquelas pacientes que desejem gestar, uma minuciosa avaliação dos riscos e aconselhamento genético antes da concepção, além de rigoroso seguimento perinatal.…”

Section: Discussionunclassified

Síndrome de Turner – desfecho de uma gestação espontânea

et al. 2017

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RESUMOObjetivo: a síndrome de Turner afeta aproximadamente 1:2.500 meninas nascidas vivas e decorre da ausência completa ou parcial do segundo cromossomo X. Embora o hipogonadismo e a infertilidade sejam os achados mais frequentes, 2-5 % das mulheres podem engravidar naturalmente. O objetivo deste trabalho é relatar o desfecho de uma gravidez espontânea em portadora de síndrome de Turner e apresentar uma revisão sobre o manejo dessa associação incomum. Relato do caso: paciente com síndrome de Turner diagnosticada aos 8 anos, cariótipo 45,X(4%)/46,XX(96%), apresentou desenvolvimento puberal espontâneo e menarca placentomegalia e polidramnia. A gestação evoluiu para trabalho de parto prematuro, com óbito do recém-nascido após 3 horas de vida. A paciente desenvolveu sintomas de depressão pós-parto, sendo encaminhada para acompanhamento psicológico. Conclusão: a gestação espontânea em uma mulher com síndrome de Turner é um evento raro. Há aumento de risco de malformações fetais, abortos espontâneos e natimortos, uma frequência elevada de complicações maternas e alta taxa de mortalidade. Complicações maternas mais comuns são diabetes gestacional, hipotireoidismo, hipertensão, pré-eclâmpsia, eclâmpsia e risco de dissecção/ ruptura da aorta, sendo fundamental acompanhamento multidisciplinar pré-concepcional e pré-natal.Palavras-chave: Síndrome de Turner. Gravidez de alto risco. Complicações na gravidez. ABSTRACTObjectives: Turner syndrome affects approximately one in 2500 live-born females and results from the complete or partial absence of the second sex chromosome. Although hypogonadism and infertility are the most frequent features, 2-5% may present spontaneous pregnancy. The purpose of this paper is to report the outcome of a spontaneous pregnancy in a patient with Turner syndrome and to review management of this unusual association. Case report: the patient diagnosed with Turner syndrome at 8 years old, with 45,X(4%)/46,XX(96%) karyotype, had spontaneous pubertal development and menarche at 15 years old. Spontaneous pregnancy occurred at age 28 and at the 32nd week of gestation ultrasound evaluation revealed hydrops fetalis, placentomegaly and polyhydramnios. The patient developed complications, including preterm birth and newborn death after three hours. Later she presented with postpartum depression. Conclusion: spontaneous pregnancy in woman with Turner syndrome is a rare event. There is an increased risk of chromosomal abnormalities, miscarriages and stillbirths, as well as an increased frequency of complications during pregnancy and higher mortality. The most common complications are gestational diabetes, hypothyroidism, hypertension, preeclampsia, eclampsia and increased risk of aortic dissection/rupture. These life-threatening conditions warrant multidisciplinary counseling prior to conception and during the prenatal period.

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Fertility preservation in Turner syndrome

Cited by 79 publications

References 86 publications

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

The role of fertility preservation in patients with endometriosis

Síndrome de Turner – desfecho de uma gestação espontânea

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