Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

“…Ovarian tissue removal, cryopreservation, and later transplantation back into an individual has successfully restored both fertility and endocrine function [14][15][16]. In fact, autologous transplantations of thawed ovarian cortical tissue have resulted in 17 reported live births [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. However, the data surrounding ovarian transplantation is controversial because typically only positive outcomes are reported, thus obscuring the success rate.…”

Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report

“…Live birth rates after oocyte banking have been reported to range between 2% and 5% per oocyte banked, and over 1,000 births have been reported to date [14,[21][22][23]. Autologous transplantation of previously frozen and thawed ovarian cortical tissue has resulted in 13 live births to date [24], including a live birth in a patient with sickle cell disease treated with HCT [25]. Nonetheless, counseling can be particularly difficult in patients like the one described since limited data exist on the risks associated with fertility preservation strategies in women with coexisting medical conditions.…”

Fertility Preservation in Reproductive-Age Women Facing Gonadotoxic Treatments

“…Grafts become hormonally active 3-4 months after transplantation, at which time oocyte harvesting can be attempted, with or without the aid of exogenous gonadotropins to stimulate follicle development. To date, more than 23 live births have been reported in humans; however, some could have originated from the contralateral in situ ovary, because only one ovary is typically harvested [132][133][134][135][136][137][138] . Several groups are currently experimenting with whole-ovary vitrification and transplantation as a means to improve efficiency and clinical outcomes [139][140][141][142] .…”