Littoral cell angioma of the spleen: Appearance on sonography and CT

Goldfeld, Moshe; Cohen, Isaac; Loberant, Norman; Mugrabi, Ahmed; Katz, Igor; Papura, Sorin; Noi, Ivan

doi:10.1002/jcu.10101

Cited by 24 publications

(16 citation statements)

References 14 publications

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“…CT, MRI, US, and Tc99m RBC scan characteristics have been correlated with histological and immunohistochemical pathological features [5] . Consistent CT features of splenic LCA reported in the medical literature include low-attenuating lesions on contrastenhanced images [2,6] . Morphological diagnosis is based on the presence of anastomosing vascular channels lined with tall endothelial cells, focal papillary fronds, and normal splenic sinuses at the periphery of the lesion.…”

Section: Discussionmentioning

confidence: 56%

Littoral-cell angioma of the spleen: A case report

Cosme¹

2007

WJG

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Littoral-cell angioma (LCA) is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp. We report a case of LCA of the spleen, which has been infrequently communicated in the literature. A 76-year-old man with a 2-wk history of weight loss, abdominal pain and changes in bowel habits was admitted to our hospital. Imaging studies (CT and MRI) showed multiple lesions in the spleen. Splenectomy was performed. Lining cells were positive for CD31/CD68 markers. Our case was associated with a serrated colonic adenoma. LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules.

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Section: Discussionmentioning

confidence: 56%

Littoral-cell angioma of the spleen: A case report

Cosme¹

2007

WJG

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“…Endothelial markers like CD31 as well as histiocytic markers such as CD68 and lysozyme is thought to be pathognomic of LCA [4], [5], [6] and establishes the pathological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Case report of a littoral cell angioma of the spleen and accessory spleens: A benign vascular tumour

Pillay

Shokeir

2017

International Journal of Surgery Case Reports

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IntroductionLittoral- cell angioma (LCA) is a rare benign vascular tumour of the spleen. There have been less then 80 cases reported in the literature.Recent reports have described it to be a malignant lesion with congenital and immunologic associations. We report a case of LCA of the spleen.Presentation of caseA 52 -year-old male patient was admitted to hospital with a three month duration of intermittent upper abdominal pain and nausea. Imaging studies, including computer tomography (CT) and magnetic resonance imaging (MRI), showed multiple lesions in the spleen as well as in the accessory spleens.An open splenectomy was performed and his post-operative recovery was uneventful.DiscussionLittoral cell angioma of the spleen is a benign vascular tumour that has been infrequently reported in the English literature. While it does have malignant potential, the vast majority are benign. Diagnosis depends on the expression of endothelial markers like CD31 and histiocytic markers like CD68.Malignant potential is enhanced by the presence of splenomegaly as well.ConclusionThis rare condition is made even more rare by the presence of the tumour in the two accessory spleens as well.

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“…Görg et al 16 reported 2 cases and reviewed 5 additional cases of littoral cell angioma in the literature; all cases were hyperechoic, and 6 (86%) were multiple lesions. However, in 20 cases of littoral cell angioma reported in the English literature, [3][4][5][6][7][8][9][10][11][12][17][18][19][20][21][22][23][24] 10 cases (50%) were hyperechoic, 10 (50%) were hypoechoic or isoechoic, and 12 (60%) were multiple lesions. In our study, 2 patients (29%) had multiple hyperechoic lesions, and 5 (71%) had solitary hypoechoic lesions.…”

Section: Discussionmentioning

confidence: 99%

Littoral Cell Angioma of the Spleen

Yunhua

Liu

Wang

et al. 2013

Journal of Ultrasound in Medicine

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Objectives The purpose of this study was to evaluate the sonographic and pathologic features of littoral cell angioma of the spleen in 7 patients. Methods The sonographic appearance in 7 cases of littoral cell angioma confirmed by surgical pathologic examination was retrospectively reviewed. All underwent color Doppler imaging. Two underwent contrast‐enhanced sonography. The sonographic appearance was compared with pathologic findings. Results Splenic lesions were solitary in 5 cases and multiple in 2 cases. The masses ranged from 10 to 64 mm in maximum diameter. Five hypoechoic and 2 hyperechoic lesions on grayscale sonography corresponded to few and multiple blood‐filled spaces on pathologic examination, respectively. Four hypovascular lesions, 1 hypervascular lesion, and the other 2 hypervascular lesions full of color flow signals on color Doppler imaging corresponded to few, several, and multiple arteries on pathologic examination. On contrast‐enhanced sonography, 1 hypervascular lesion full of color flow signals showed homogeneous hyperenhancement for 8 minutes during the arterial and parenchymal phases. One hypovascular lesion showed inhomogeneous isoenhancement transiently during the arterial phase and became hypoechoic later. Conclusions Littoral cell angioma is a primary vascular splenic neoplasm with variable features on grayscale sonography and color Doppler imaging as well as contrast‐enhanced sonography. The sonographic appearance of littoral cell angioma mainly depends on the type and number of tumor vessels.

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Littoral cell angioma of the spleen: Appearance on sonography and CT

Cited by 24 publications

References 14 publications

Littoral-cell angioma of the spleen: A case report

Littoral-cell angioma of the spleen: A case report

Case report of a littoral cell angioma of the spleen and accessory spleens: A benign vascular tumour

Littoral Cell Angioma of the Spleen

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