Litt's Cardiac Drug Eruptions and Interactions

Litt, Jerome Z.

doi:10.1201/9780203087992

Cited by 4 publications

(20 citation statements)

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“…Systemic comorbidities may result in renal and hepatic dysfunction or lead to effusions which can act as reservoirs, thus altering the pharmacokinetics of the applied cytostatics. A higher degree of comorbidity usually results in the use of additional medication which itself can often be associated with alopecia [14]. Therefore, it is very likely that co-medication can influence the mode of action of substances applied as part of CT treatment, resulting in increased hair loss.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

et al. 2015

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Background: The influence of systemic comorbidities on the success of scalp cooling during chemotherapy (CT) is widely unexplored. Comorbidities often require additional medication which itself can occasionally cause alopecia. This study investigates the influence of selected parameters on the efficacy of scalp cooling for the prevention of CT-induced alopecia. Patients and Methods: 226 cancer patients were treated with various CT regimens in combination with sensor-controlled scalp cooling. 136 breast cancer patients received (neo)adjuvant therapy, and 76 of these patients received epirubicine and cyclophosphamide (4× EC 3w) followed by paclitaxel (12× T w). The following parameters were prospectively investigated: chemotherapy-induced alopecia, systemic comorbidities and co-medication, nicotine abuse, hair treatment, menopausal status, and trichologic status. Results: Scalp cooling was successful (no or not visible hair loss; common toxicity criteria 0-1) in 65% of all patients, in 65% of the 136 breast cancer patients, and in 68% of the 76 patients receiving EC/T. In this subgroup, premenopausal patients (p = 0.009) and those without systemic comorbidities (p = 0.003), without co-medication (p < 0.001) and with high hair density (p = 0.038) showed less hair loss during CT; an effect was also seen for nicotine abuse (p = 0.023). Hair length and hair treatment had no significant influence. Conclusion: Sensor-controlled scalp cooling represents an effective addition to supportive cancer therapy. The success of scalp cooling depends on the applied CT regimen. Parameters like menopausal status, systemic comorbidities, medication, nicotine abuse, and original hair density also influence the outcome of hair loss prevention.

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Section: Introductionmentioning

confidence: 99%

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

et al. 2015

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“…Aside from edema, this class of medications is relatively benign from a cutaneous adverse effect standpoint. Alopecia is reported as a side effect in less than 1 % of patients [ 26 ].…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Alopecias

Salkey¹

2015

Dermatological Manifestations of Kidney Disease

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“…Hydroxyzine, chlorpheniramine, and cyproheptadine have marked atropine-like side effects such as dry mouth, blurred vision and constipation [71].…”

Section: Anticholinergic and Antiserotonergic Side Effectsmentioning

confidence: 99%

Adverse Systemic Reactions of Antihistamines: Highlights in Sedating Effects, Cardiotoxicity and Drug Interactions

Kus¹

2005

CMCAIAA

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Antihistamines are already among the most frequently used pharmaceutical compounds and with the predictable increase of the prevalence of atopic disease, even more patients are expected to use them in future. Though the common belief on their safety has existed since some decades, they, including the over the counter ones, might potentially bear serious side effects. Thus , the following article focuses on the adverse effects of antihistamines by summarizing the current data mainly on central nervous system and cardiovascular side effects. Meanwhile, less common side effects, and important issues like their use in pregnancy and lactation are also included. Updated information is provided on drug interactions and overdose situations along with their management. As a finalstep, pitfalls in choosing suitable antihistamine/s in special circumstances to avoid adverse effects are also covered.

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Litt's Cardiac Drug Eruptions and Interactions

Cited by 4 publications

References 0 publications

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

Alopecias

Adverse Systemic Reactions of Antihistamines: Highlights in Sedating Effects, Cardiotoxicity and Drug Interactions

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