Litophynin C, a New Insect Growth Inhibitory Diterpenoid from a Soft Coral Litophyton sp.

Abstract

A new diterpenoid, litophynin C, which exhibits insect growth inhibitory activity against the silkworm, Bombyx mori L., has been isolated from a soft coral Litophyton sp., and its structure including the absolute configuration established on the basis of spectral and chemical evidence.

Bioactive Terpenoids from Octocorallia, I. Bioactive Diterpenoids: Litophynols A and B from the Mucus of the Soft Coral Litophyton sp.

“…A [1] and B [2], together with three known diterpenoids, litophynin E [3], H [11] (5), and litophynin I monoacetate [12] (6).…”

New Cladiellane Diterpenes from the Soft Coral Cladiella australis of the Andaman and Nicobar Islands

“…The EtOH extract of C. australis Macfadyen, 1936 (Alcyoniidae) was digested in EtOAc and the soluble portion was chromatographed on Si gel using solvents with increasing polarity from petroleum ether to EtOAc to obtain several fractions, which on exhaustive rechromatography yielded nine pure compounds. Two compounds were identified as sclerophytins -C [7} and -E [8], by comparison of spectral data with literature values for metabolites of Sclerophytum capitalis (7)(8).2 Two metabolites, sclerophytin-C 6-ethyl ether [9], and sclerophytin-E 6-ethyl ether [10] were characterized and considered artifacts because EtOH had been used in the extraction process. The structures of five compounds, (l/?*,2/?*,3/?*,65'*,75'*,9/?*,10/?*,l4/?…”

“…Soft corals have a reputation as prolific producers of terpenoid metabolites, mostly diterpenes (1)(2)(3)(4). Diterpenes possessing the tricyclic skeleton of cladiellin [1] (5) are comparatively rare in soft corals and only a few have been reported (6)(7)(8)(9)(10)(11)(12)(13). Cladiella australis from the Andaman and Nicobar Islands, Indian Ocean, was examined and we report in this paper the isolation and structural elucidation of five new cladiellanes.…”

Marine Natural Products as Prototype Insecticidal Agents

“…Litophynins A (15) and C ( 16) are additional examples of highly oxidized asbestinin-related diterpene esters isolated from the soft coral Liptophyton sp. They showed insect growth inhibitory activity (Ochi et al, 1987(Ochi et al, , 1988. Calicophirins A (17) and B (18) are related insect growth inhibitor diterpenes isolated from the gorgonian coral Calicogorgia sp.…”