Lithotriptic Effect of Combination of Matsyakshi (Alternanthera Sessilis Linn. R.BR.,) and Tender Coconut Water in Albino Rats

Objective: To analyze the effect of coconut water administration on the occurrence of urolithiasis in calcium oxalate-induced Wistar rats. Material & Methods: Laboratory experimental study with post-test only control group design, using experimental model of male Rattus norwegicus-Wistar strains. The treatment given is ad libitum administration coconut water to observe its effect on renal histopathological changes, microscopic analysis, and renal function markers. Urolithiasis induction uses exposure of 0.75% ethylene glycol (EG), and 2% Ammonium chloride (AC) in drinking water. Results: Descriptive analysis showed the tendency of decreasing in mean of renal function markers, and histopathological nephron damage in the treatment group versus control group: BUN (11.22 versus 14.29); Creatinine Serum (0.5308 versus 0.5714); degree of nephron damage (5.22 versus 10.36). In microscopic analysis, there were calcium deposits in the kidney tubules in the control group, which were not found in the treatment group. Based on the ANOVA test, obtained significant difference in BUN levels with p value=0.023 (p<0.05), and the degree of nephron damage between study groups with p value= 0.000 (p<0.05). There was no significant difference in serum creatinine with p value= 0.23 (p>0.05). Conclusion: Coconut water is potential modality in inhibiting the deposition of calcium oxalate crystals, and protecting from impaired kidney function against urolithiasis in animal-model of calcium oxalate-induced Wistar rats.

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The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Singla

Dhir

Madaan

et al. 2022

Front. Pharmacol.

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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Lithotriptic Effect of Combination of Matsyakshi (Alternanthera Sessilis Linn. R.BR.,) and Tender Coconut Water in Albino Rats

Cited by 4 publications

References 10 publications

Health Benefits of Coconut Water

Health Benefits of Coconut Water

Effects of Coconut Water (Cocos Nucifera Sp.) Administration as Prevention of Urolithiasis in Calcium Oxalate Induced - White Rat Wistar Strains

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

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