Lithium enhances alveolar bone formation during orthodontic retention in rats

Pan, Jin; He, Shushu; Yin, Xing; Li, Y.; Zhou, Chenchen; Zou, Shujuan

doi:10.1111/ocr.12190

Cited by 14 publications

(28 citation statements)

References 33 publications

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“…In support of these findings, previous investigations have demonstrated potential benefits of lithium chloride on fracture healing (26,27) and alveolar bone repair (16)(17)(18)(19)(20)(21). Han et al (16) demonstrated that local administration of lithium chloride stimulated greater alveolar bone volume and mineral density during the healing of surgicallycreated periodontal defects in estrogen-sufficient rats.…”

Section: Discussionmentioning

confidence: 76%

“…Pre-clinical dental studies have shown benefits of lithium chloride, in states of both estrogen sufficiency and deficiency, on bone formation during orthodontic retention, midpalatal expansion and surgically-created periodontal defects, for improving implant osseointegration and for the attenuation of bone loss in a model of induced periodontitis (15)(16)(17)(18)(19)(20). A single previous study in estrogen-sufficient rats evaluated the effects of lithium chloride on the healing process of tooth sockets.…”

Section: Introductionmentioning

confidence: 99%

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Systemic Lithium Chloride Administration Improves Tooth Extraction Wound Healing in Estrogen-Deficient Rats

et al. 2020

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The purpose of this investigation was to evaluate the effects of lithium chloride (LiCl) on the socket healing of estrogen-deficient rats. Seventy-two rats were allocated into one of the following groups: Control, Ovariectomy and LiCl (150 mg/kg/2 every other day orally) + Ovariectomy. Animals received LiCl or water from the 14th day post-ovariectomy, until the completion of the experiment. On the 21st day after ovariectomy, the first molars were extracted. Rats were euthanized on the 10th, 20th and 30th days following extractions. Bone healing (BH), TRAP positive cells and immunohistochemical staining for OPG, RANKL, BSP, OPN and OCN were evaluated. The Ovariectomy group presented decreased BH compared to the LiCl group at 10 days, and the lowest BH at 20 days (p<0.05). At 30 days, the Ovariectomy and LiCl-groups presented lower BH than that of the Control (p<0.05). The number of TRAP-stained cells was the lowest in the LiCl group at 20 days and the highest in the Ovariectomy group at 30 days (p<0.05). At 10 days of healing, the LiCl group demonstrated stronger staining for all bone markers when compared to the other groups, while the Ovariectomy group presented higher RANKL expression than that of the Control (p<0.05). LiCl enhanced bone healing in rats with estrogen deficiency, particularly in the initial healing phases. However, as data on the effects of lithium chloride on bone tissue are still preliminary, more studies related to its toxicity and protocol of administration are necessary before its application in clinical practice.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Systemic Lithium Chloride Administration Improves Tooth Extraction Wound Healing in Estrogen-Deficient Rats

et al. 2020

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“…LiCl promotes implant osseointegration and osteogenesis in osteoporotic rats [28,29]. LiCl treatment increased the alveolar bone mass during orthodontic retention [30]. Combination of LiCl and LY294002 increased osteoblastic differentiation but decreased osteoclast differentiation [31].…”

Section: Discussionmentioning

confidence: 99%

Lithium chloride enhances osteoblast differentiation and resists senile osteoporosis

Bao

Tang

et al. 2020

Preprint

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Background Lithium chloride (LiCl) is commonly used in the clinic for the treatment of bipolar and other mental disorders. LiCl is an inhibitor of GSK-3β, and has been reported to modulate the balance of adipogenesis and osteogenesis. But, whether LiCl impacts bone formation and homeostasis in senile osteoporosis is still unclear. Methods Analysis of tibia in 2, 5, 7 and 10 months old C57BL/6 male mice were performed by MicroCT (μCT). 7 months old wild-type mice were treated with LiCl orally 0, 100 or 200 mg/kg for 3 months and then tested by μCT. The levels of osteogenesis marker genes and Wnt signaling target genes in bone marrow stromal cells (BMSCs) were detected by reverse transcription quantitative polymerase chain reaction and immunostaining. BMSCs were induced osteoblast differentiation and tested by Alizarin red S staining. Results μCT analyses of C57BL/6 mice showed that bone mineral density (BMD) and trabecular thickness (Tb.Th) increased until the bone mass peaked (5 months) and then began to fall subsequently. LiCl dramatically enhanced bone mass in the senile osteoporotic conditions, represented by increased ratio of bone volume to tissue volume (BV/TV), and decreased in trabeculae separation (Tb.Sp). Moreover, LiCl significantly increased both canonical osteoblastogenesis and Wnt signaling activity without affecting hormones. Conclusion This study uncovered the role of LiCl in canonical Wnt signaling and bone formation and have provided the evidence that LiCl may potentially repress senile osteoporosis.

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“…Another interesting and unusual element adopted as inorganic components in the functionalization was lithium: after an initial observation of beneficial effect on bone status in patients undergoing lithium therapy for mental disorders, lithium proved to promote osteogenic differentiation, via activation of the Wnt signalling pathway, inhibiting glycogen synthase kinase-3beta (GSK-3β) [85].…”

Section: Discussionmentioning

confidence: 99%

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

et al. 2019

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Background: The success of reconstructive orthopaedic surgery strongly depends on the mechanical and biological integration between the prosthesis and the host bone tissue. Progressive population ageing with increased frequency of altered bone metabolism conditions requires new strategies for ensuring an early implant fixation and long-term stability. Ceramic materials and ceramic-based coatings, owing to the release of calcium phosphate and to the precipitation of a biological apatite at the bone-implant interface, are able to promote a strong bonding between the host bone and the implant. Methods: The aim of the present systematic review is the analysis of the existing literature on the functionalization strategies for improving the implant osteointegration in osteoporotic bone and their relative translation into the clinical practice. The review process, conducted on two electronic databases, identified 47 eligible preclinical studies and 5 clinical trials. Results: Preclinical data analysis showed that functionalization with both organic and inorganic molecules usually improves osseointegration in the osteoporotic condition, assessed mainly in rodent models. Clinical studies, mainly retrospective, have tested no functionalization strategies. Registered trademarks materials have been investigated and there is lack of information about the micro- or nano- topography of ceramics. Conclusions: Ceramic materials/coatings functionalization obtained promising results in improving implant osseointegration even in osteoporotic conditions but preclinical evidence has not been fully translated to clinical applications.

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Lithium enhances alveolar bone formation during orthodontic retention in rats

Abstract: LiCl enhances alveolar bone formation during orthodontic retention in rats.

Cited by 14 publications

References 33 publications

Systemic Lithium Chloride Administration Improves Tooth Extraction Wound Healing in Estrogen-Deficient Rats

Systemic Lithium Chloride Administration Improves Tooth Extraction Wound Healing in Estrogen-Deficient Rats

Lithium chloride enhances osteoblast differentiation and resists senile osteoporosis

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

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