Literature review of Notch melanoma receptors

Filho, Renato Santos de Oliveira; Soares, Alexandre L; Paschoal, Francisco Macedo; Rezze, Gisele Gargantini; Oliveira, Ebe Christie de; Macarenco, Ricardo; Buzaid, Antônio C.; Ferreira, Lydia Masako

doi:10.1186/s42047-019-0052-9

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…It's also involved in neurodegenerative diseases, such as Alzheimer's and developmental disorders. Even though it is primarily oncogenic, Notch has already been identified as a tumor suppressor 4,5,6 . Elevated levels of Notch1-4 expression have already been associated with metastatic and primary melanoma strains, whereas, in normal melanocytes and nevi, Notch levels are low or undetectable 4,7,8 , demonstrating the importance of this pathway in the development of this type of tumor.…”

Section: 3mentioning

confidence: 99%

Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review

Filho¹,

Peixoto²,

Sangiuliano³

et al. 2021

Braz. J. Nat. Sci

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Melanoma is the skin cancer with higher mortality and more and more cases are arising every year. Overexpression of Notch signaling pathway elements have already been found in primary and metastatic melanoma lineages, and directly correlated to melanoma’s development, growth, angiogenesis, metastasis, and resistance to treatment. Thus, target therapy against Notch in melanoma presents a high potential for the treatment of this type of cancer. In this review we aim to perform a narrative review on melanoma’s possible treatments targeting the Notch pathway. We searched literature about Notch signaling pathway inhibitors in human cutaneous melanoma published between 2000 and 2020 using MEDLINE (via PubMed), LILACS (via Biblioteca Virtual em Saúde) and Cochrane Library databases. The selected articles were analyzed, summarized, tabulated, and used to produce the present narrative review. The 24 selected articles, as well as articles referenced in them, presented as targeting therapy against Notch, γ-secretase inhibitors (GSIs), primarily, but also gliotoxin, honokiol, phospholipase A2, andrographolide and monoclonal antibodies, that, however, were not directly studied in melanoma. Another therapy that indirectly interfered in the Notch signaling pathway and was found in these articles were G9a inhibitors. Analyzing the collected data, it was possible to conclude that GSIs, more extensively studied, are probably not the best option for melanoma’s treatment, exceeding specific scenarios or through their concomitant use with other pathways inhibitors. The use of the other compounds, on the other hand, has greater potential, however, more studies are needed to prove its effectiveness and viability for the treatment of human cutaneous melanoma.

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Section: 3mentioning

confidence: 99%

Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review

Filho¹,

Peixoto²,

Sangiuliano³

et al. 2021

Braz. J. Nat. Sci

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Identification and quantification of notch receptors in human cutaneous melanoma using molecular biology techniques: literature review

et al. 2020

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Background The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer. There are several methods of molecular biology to identify and quantify Notch receptors and it is essential to study them for understanding the different results, advantages and disadvantages of each. Main body The present study brings a bibliographic review on the molecular biology methods used in the identification and quantification of these molecules, aiming to facilitate research involving Notch receptors in human melanoma. We identified as main methods of molecular biology Western Blotting, Quantitative real-time polymerase chain reaction and DNA microarrays. A brief description of these methodologies is made and the advantages and disadvantages of each are discussed. Results concerning the function of this pathway are also discussed. Short conclusion It is known that the activation of Notch receptors is tumorigenic in most cases, however, depending on the microenvironment, it can provide tumor suppression. The adequate choice and use of the methodology for identification and quantification of Notch receptors is essential for the progress of knowledge of this important signaling pathway, which, certainly, will allow advances in the treatment of cutaneous melanoma.

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Literature review of Notch melanoma receptors

Cited by 2 publications

References 57 publications

Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review

Notch receptors as a therapeutic target in melanoma: a narrative bibliographic review

Identification and quantification of notch receptors in human cutaneous melanoma using molecular biology techniques: literature review

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