Literature-related discovery (LRD): Potential treatments for Multiple Sclerosis

Kostoff, Ronald N.; Briggs, Michael B.; Lyons, Terence J.

doi:10.1016/j.techfore.2007.11.002

Cited by 43 publications

(34 citation statements)

References 39 publications

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“…[39] There is also a more trivial theory which says that MS is not an autoimmune disease but is a metabolic neurodegenerative disorder. However, the main cause of MS is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Uses of Complementary and Alternative Medicine in Multiple Sclerosis

Namjooyan

Ghanavati

Majdinasab

et al. 2014

Journal of Traditional and Complementary Medicine

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Multiple sclerosis (MS) is a chronic, disabling, recurrent demyelination of the central nervous system (CNS). It could affect different regions in the brain and spinal cord, and according to the domain which is affected, it could cause different symptoms such as motor, sensory, or visual impairment; fatigue; bowel, bladder, and sexual dysfunction; cognitive impairment; and depression. MS patients also face reduced quality of life. Drugs that are used in MS are not fully efficient and patients suffer from many symptoms and adverse effects. Today there is an increasing trend of using complementary and alternative medicine (CAM). People are more likely to use this type of treatment. Using appropriate lifestyle and CAM therapy can subside some of the symptoms and could improve the quality of life in these patients. Many people with MS explore CAM therapies for their symptoms. This review is aimed to introduce CAM therapies that could be used in MS patients.

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“…[39] There is also a more trivial theory which says that MS is not an autoimmune disease but is a metabolic neurodegenerative disorder. However, the main cause of MS is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Uses of Complementary and Alternative Medicine in Multiple Sclerosis

Namjooyan

Ghanavati

Majdinasab

et al. 2014

Journal of Traditional and Complementary Medicine

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“…In 2008-2009, our research group published 1) a detailed review of the complete LRDI literature in ARIST [1], 2) a journal Special Issue devoted to the LRDI methodology and applications circa 2007 [2][3][4][5][6][7][8][9], and 3) a comprehensive report that covered all the studies in the journal Special Issue and some raw data as well [10]. In 2011, I published an LRDI study on the SARS pandemic/coronavirus [11].…”

Section: Purpose Of Articlementioning

confidence: 99%

Literature-related discovery and innovation — update

Kostoff

2012

Technological Forecasting and Social Change

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Literature-Related Discovery and Innovation (LRDIformerly LRDliterature-related discovery) integrates 1) discovery generation from disparate literatures with 2) the wealth of knowledge contained in prior art to 3) potentially reverse chronic and infectious diseases and/or 4) potentially solve technical problems that appear intractable. This article describes the evolution of LRDI by the author and the insights gained/lessons learned over the past decade. To illustrate the potential power of LRDI, the article emphasizes the relationship between the results of our 2008 LRDI multiple sclerosis (MS) study and a recent demonstration of MS reversal. Lessons learned from the six LRDI medical studies done so far include:⁎ The main operational problem in the author's LRDI approach is selecting the most important concepts from extremely large volumes of potential discovery retrieval. This is contrary to most published LRDI research, where the discovery focus is searching for rare events. ⁎ It is important to have topical specialist(s) working closely with information technologist(s); the topical specialist(s) applies judgment in selecting the most important concepts. ⁎ A functional form of the information retrieval query with proximity searching capability provides highly selective filtering for discovery retrieval and core prevention/treatment retrieval; the functional form of the query with proximity searching capability allows the use of full-text for discovery and core prevention/treatment. ⁎ Bibliographic coupling (identifying papers that share common references) combined with text-based relationships strengthens selection for potential discovery further. ⁎ Having 'skin-in-the-game' (being affected personally) relative to the medical outcome is a strong incentive to do whatever is necessary to solve the research problem. ⁎ Hormesis is critical to healing; relatively modest doses of stimuli tend to be beneficial, whereas relatively large doses may be harmful. The synergy of hormetic treatment doses produces effects larger than combinations of individual doses and requires smaller doses when combined; the synergy of hormetic doses allows conversion of megadoses of nutrients typically reported in lab/clinical studies to physiological (food-level) doses and associated increased safety. ⁎ Co-promoters (combinations of toxic stimuli required to produce disease symptoms) are extremely important for explaining seemingly conflicting results; if true co-promotion is present, elimination of one of the co-promoters may be adequate for removing symptoms, even though the overall problem persists. ⁎ Prior art (potential treatments already published in the literature but not pursued by mainline medicine) may have much to contribute to potentially solve many serious medical problems; much of prior art is overlooked, especially low-tech prior art (e.g., foods, food extracts, herbs, etc.).⁎ Systemic and focused treatments are both necessary components of healing, but neither will be fully, or many times even partially, effective until t...

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“…A 2009 review paper by the author showed that, while a number of LRD published papers claimed to have generated potential discovery, essentially none of these claims could be validated [1]. The only published LRD potential discovery claims that could be validated as credible hypotheses were in a journal Special Issue devoted to LRD (e.g., [2,3]). The four medical papers in this Special Issue describe the application of ODS LRD to four chronic diseases: Raynaud's Phenomenon (RP), cataracts, Parkinson's Disease (PD), and Multiple Sclerosis (MS).…”

Section: Overview and Backgroundmentioning

confidence: 99%

Literature-related discovery: Potential treatments and preventatives for SARS

Kostoff

2011

Technological Forecasting and Social Change

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Literature-related discovery (LRD) is the linking of two or more previously disjoint concepts in order to produce novel, interesting, plausible, and intelligible connections (i.e., potential discovery). LRD has been used to identify potential treatments or preventative actions for challenging medical problems, among myriad other applications. Severe acute respiratory syndrome (SARS) was the first pandemic of the 21st century. SARS was eventually controlled through increased hygienic measures (e.g., face mask protection, frequent hand washing, living quarter disinfection), travel restrictions, and quarantine. According to recent reviews of SARS, none of the drugs that were used during the pandemic worked. For the present paper, SARS was selected as the first application of LRD to an infectious disease. The main goal of this research was to identify non-drug non-surgical treatments that would 1) prevent the occurrence, or 2) reduce the progression rate, or 3) stop/reverse the progression of SARS. The MeSH taxonomy of Medline was used to restrict potential discoveries to selected semantic classes, and to identify potential discoveries efficiently. To enhance the volume of potential discovery, databases were used in addition to Medline. These included the Science Citation Index (SCI) and, in contrast to previous work, a full text database. Because of the richness of the full text, 'surgical' queries were developed that targeted the exact types of potential discovery of interest while eliminating clutter more efficiently.

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Literature-related discovery (LRD): Potential treatments for Multiple Sclerosis

Cited by 43 publications

References 39 publications

Uses of Complementary and Alternative Medicine in Multiple Sclerosis

Uses of Complementary and Alternative Medicine in Multiple Sclerosis

Literature-related discovery and innovation — update

Literature-related discovery: Potential treatments and preventatives for SARS

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