Multiple sclerosis (MS) is a chronic, disabling, recurrent demyelination of the central nervous system (CNS). It could affect different regions in the brain and spinal cord, and according to the domain which is affected, it could cause different symptoms such as motor, sensory, or visual impairment; fatigue; bowel, bladder, and sexual dysfunction; cognitive impairment; and depression. MS patients also face reduced quality of life. Drugs that are used in MS are not fully efficient and patients suffer from many symptoms and adverse effects. Today there is an increasing trend of using complementary and alternative medicine (CAM). People are more likely to use this type of treatment. Using appropriate lifestyle and CAM therapy can subside some of the symptoms and could improve the quality of life in these patients. Many people with MS explore CAM therapies for their symptoms. This review is aimed to introduce CAM therapies that could be used in MS patients.

Objective: According to effects that cinnamon, ajwain and Iranian borago shows in involving mechanisms in MS and MS animal model, we decided to survey the affect of traditional formulation on MS patient by clinical trial. Methods: in a double blind randomized clinical trial study, 60 patients with (MS) observed. They take formulation 15cc per day, fill the MSQOL-54, and fatigue questionnaires every month. The data were analyzed with 18th version of SPSS, independent t-Test and repeated measure tests. The p-value for tests was 0.05. Results: the mean quality of life and fatigue of patient with MS were significantly changed during 3 month. Conclusion: most patients with MS had better quality of life during 3 month and get less tired. In some patient tremor and pain reduce. Because of good result and revenue of formulation, it seems to be useful for MS patient.

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