List-learning and verbal memory profiles in childhood epilepsy syndromes

Schraegle, William A.; Nussbaum, Nancy L.; Stefanatos, Arianna K.

doi:10.1016/j.yebeh.2016.07.021

Cited by 11 publications

(8 citation statements)

References 43 publications

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“…In total, data were available for 29 samples. In total, 17 cohorts reported only on CAE (Berg et al, 2011; Berg et al, 2014; Caplan et al, 2008; Cerminara et al, 2013; Cheng et al, 2017; Conant et al, 2010; D’Agati et al, 2012; Gencpinar et al, 2016; Guerrini et al, 2015; Kernan et al, 2012; Levav et al, 2002; Lopes et al, 2014; Lopes et al, 2013; Masur et al, 2013; Mostafa et al, 2014; Nolan et al, 2004; Oostrom et al, 2003; Schraegle et al, 2016; Shinnar et al, 2017; Siren et al, 2007; Talero-Gutierrez et al, 2015; Vega et al, 2010; Wirrell et al, 1996) and in 12 cohorts reports were available in children with AE or a combination of CAE with JAE (Conde-Guzon & Cancho-Candela, 2012; Covanis et al, 1992; Fastenau et al, 2009; Franzoni et al, 2015; Henkin et al, 2003; Henkin et al, 2005; Oostrom et al, 2003; Pavone et al, 2001; Sinclair & Unwala, 2007; Siren et al, 2007; Talero-Gutierrez et al, 2015; Urena-Hornos et al, 2004; Vanasse et al, 2005; Verrotti et al, 2011). No studies were available reporting on JAE exclusively.…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies assessed memory function (Conant et al, 2010; Conde-Guzon & Cancho-Candela, 2012; D’Agati et al, 2012; Gencpinar et al, 2016; Henkin et al, 2005; Kernan et al, 2012; Levav et al, 2002; Lopes et al, 2014; Masur et al, 2013; Mostafa et al, 2014; Nolan et al, 2004; Pavone et al, 2001; Schraegle et al, 2016; Siren et al, 2007). Pavone et al used the Test Of Memory And Learning (TOMAL) and found significant impairments in the Nonverbal Memory Index Score, Delayed Recall Index and Kernan et al found significant differences in the Memory for Stories Subtest Scores compared to control subjects (Kernan et al, 2012; Pavone et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

“…However, other studies on non-verbal memory tests have overall found average performance (Conant et al, 2010; D’Agati et al, 2012; Gencpinar et al, 2016; Henkin et al, 2005; Kernan et al, 2012; Lopes et al, 2014; Nolan et al, 2004; Pavone et al, 2001; Siren et al, 2007). Furthermore, studies on verbal memory mostly showed normal performance (Levav et al, 2002; Lopes et al, 2014; Schraegle et al, 2016). Nevertheless, some studies using subtests for memory for stories and with the California Verbal Learning Test did find lower performance compared to controls (Conant et al, 2010; Henkin et al, 2005; Kernan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The number of studies reporting on cognitive performance in AE has been growing steadily and warrants a formal review (Berg, Caplan, & Hesdorffer, 2011; Berg, Levy, Testa, & Blumenfeld, 2014; Caplan et al, 2008; Cerminara et al, 2013; Cheng et al, 2017; Conant, Wilfong, Inglese, & Schwarte, 2010; Conde-Guzon & Cancho-Candela, 2012; Covanis, Skiadas, Loli, Lada, & Theodorou, 1992; D’Agati, Cerminara, Casarelli, Pitzianti, & Curatolo, 2012; Fastenau et al, 2009; Franzoni et al, 2015; Gencpinar et al, 2016; Guerrini et al, 2015; Henkin et al, 2003; Henkin et al, 2005; Kernan et al, 2012; Levav et al, 2002; Lopes, Monteiro, Fonseca, Robalo, & Simoes, 2014; Lopes et al, 2013; Masur et al, 2013; Mostafa, Talaat, Shalaby, El-Fayoumy, & Labib, 2014; Nolan et al, 2004; Oostrom et al, 2003; Pavone et al, 2001; Schraegle, Nussbaum, & Stefanatos, 2016; Shinnar et al, 2017; Sinclair & Unwala, 2007; Siren et al, 2007; Talero-Gutierrez, Sanchez-Torres, & Velez-van-Meerbeke, 2015; Urena-Hornos et al, 2004; Vanasse, Beland, Carmant, & Lassonde, 2005; Vega et al, 2010; Verrotti et al, 2011; Wirrell, Camfield, Camfield, Gordon, & Dooley, 1996). A previous meta-analysis in idiopathic generalized epilepsy found significant impairments in general cognitive ability and across a wide variety of other cognitive domains (Loughman, Bowden, & D'Souza, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

et al. 2019

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Cognition in absence epilepsy (AE) is generally considered undisturbed. However, reports on cognitive deficits in AE in recent years have suggested otherwise. This review systematically assesses current literature on cognitive performance in children with AE. A systematic literature search was performed in Pubmed, Embase, Cochrane and Web of Science. All studies reporting on cognitive performance in children with AE were considered. In total 33 studies were eligible for inclusion. Neuropsychological tests were classified into the following domains: intelligence; executive function; attention; language; motor & sensory-perceptual examinations; visuoperceptual/visuospatial/visuoconstructional function; memory and learning; achievement. Random-effect meta-analyses were conducted by estimating the pooled mean and/or pooling the mean difference in case-control studies. Full-scale IQ in children with AE was estimated at 96.78 (95%CI:94.46–99.10) across all available studies and in case-control studies IQ was on average 8.03 (95%CI:-10.45- -5.61) lower. Verbal IQ was estimated at 97.98 (95%CI:95.80–100.16) for all studies and 9.01 (95%CI:12.11- -5.90) points lower in case-control studies. Performance IQ was estimated at 97.23 (93.24–101.22) for all available studies and 5.32 (95%CI:-8.27–2.36) points lower in case-control studies. Lower performance was most often reported in executive function (cognitive flexibility, planning, and verbal fluency) and attention (sustained, selective and divided attention). Reports on school difficulties, neurodevelopmental problems, and attentional problems were high. In conclusion, in contrast to common beliefs, lower than average neurocognitive performance was noted in multiple cognitive domains, which may influence academic and psychosocial development.Electronic supplementary materialThe online version of this article (10.1007/s11065-019-09419-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

et al. 2019

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“…31 Focusing on children 6-16 years old, another study found that 46.7% with temporal lobe epilepsy and 36.7% with frontal lobe epilepsy (FLE) had seizures daily to weekly. 25 Patients 5-22 years old with intractable TLE stemming from a focal cortical dysplasia who underwent excisional epilepsy surgery preoperatively experienced a mean of 15 daily seizures and 24% had a history of status epilepticus. 23 A study using decision analysis modeling predicted that 10-year-old patients with either refractory temporal lobe epilepsy or extratemporal lobe epilepsy would experience 7.2 years of seizure freedom with medical management versus 26.7 (temporal lobe epilepsy) or 23.3 (extratemporal lobe epilepsy) years with surgical intervention.…”

Section: Humanistic Burdenmentioning

confidence: 99%

The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States

et al. 2020

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Objective: To better understand the humanistic and economic burden of focal seizures in children 2-12 years old. Methods: We conducted a targeted literature review by searching MEDLINE for English-language publications reporting on children 2-12 years old with focal seizures published in the United States since 2008. Results: Thirty-five publications were included. Incidence of focal seizures was 23.2 to 47.1 per 100,000 children per year; prevalence was 2.0 per 1,000 children, and ranged from 1.6 - 2.6 per 1,000 in patients of any age. Life expectancy was 47.3-61.8 years among children 3-12 years old. Patients took several antiepileptic drugs and experienced frequent seizures, sleep disorders, mood disorders, migraine, and seizure-related injuries (eg, bone fractures, sprains, open wounds). Children with focal seizures scored below average on cognitive assessments and up to 42%, 16%, and 19% had depression, anxiety, and attention-deficit disorder, respectively. Patients of any age had about 10 outpatient visits (2 epilepsy-related), 2 inpatient visits (less than 1 epilepsy-related), and 24 procedures (1 epilepsy-related) per year. Medication adherence was low: only half of pediatric patients maintained ≥90% adherence over 6 months. Annual total health care costs among patients of any age ranged from $18,369 - 38,549; first-year total health care costs for children were $19,883. Conclusions: Incidence and prevalence of focal seizures is high and the humanistic and economic burdens are significant. Future studies focused exclusively on children with focal seizures are needed to more precisely describe the burden. We also suggest further research and implementation of methods to improve medication adherence as an approach to lessen burden on these young patients.

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Pediatric Epilepsy Patients Demonstrate Stability and Variability in Verbal Learning and Memory Functions Over Time

Leonard

Loi

Olsen

2023

J Pediatr Neuropsychol

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List-learning and verbal memory profiles in childhood epilepsy syndromes

Cited by 11 publications

References 43 publications

Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States

Pediatric Epilepsy Patients Demonstrate Stability and Variability in Verbal Learning and Memory Functions Over Time

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