Lissencephaly and cerebellar hypoplasia in a goat

Abstract

A case of lissencephaly and cerebellar hypoplasia was observed in a 30

Lissencephaly-pachygyria and cerebellar hypoplasia in a calf

“…The more prominent signs were motor incoordination and intention tremors of the head and neck, which are related to cerebellar hypoplasia because the cerebellum coordinates motor functions in mammals (KING, 1994). One description of the disease in a goat mentioned that the cerebellar signs were more intense, which suggests that a high degree of cerebellar cortical dysfunction may mask the signs (SANTOS et al, 2013). Heterotopia of the Purkinje neurons in the granular layer of the cerebellum was a striking finding of the present case, and the hypermetria, ataxia and tremors of the head and neck observed here were likely associated with this change.…”

“…Cerebellar hypoplasia typically occurs concurrently with lissencephaly in the classic form of the disease (DOBYNS WB & TRUWIT, 1995;GOLDEN, 2001). In the cases that have been described in cats (HERRMANN et al, 2011), lambs (PÉREZ et al, 2013, and a goat (SANTOS et al, 2013), the disease has assumed the classic form with cerebellar hypoplasia.…”

Lissencephaly in an adult Australian Kelpie

“…1,[5][6][7][8][9] Lissencephaly with concurrent cerebellar hypoplasia has been more commonly described and reports include a litter of Irish Setters, a litter of Wire-haired Fox Terriers, a Samoyed, multiple Churra lambs and a goat. 1,[10][11][12] Lissencephaly with concurrent microcephaly, hypoplasia of the corpus callosum and hypoplasia of the cerebellum has also been described in a domestic cat. 13 Lissencephaly with concurrent cranial aplasia cutis, anasarca, palatoschisis, sternal agenesis and eventeratio has been reported in a Chihuahua epigastric heteropagus twin.…”

“…Lissencephaly without concurrent malformations has been described in five Lhasa Apso dogs, a small (5 kg) mixed‐breed dog, two Korat cats and a brown bear . Lissencephaly with concurrent cerebellar hypoplasia has been more commonly described and reports include a litter of Irish Setters, a litter of Wire‐haired Fox Terriers, a Samoyed, multiple Churra lambs and a goat . Lissencephaly with concurrent microcephaly, hypoplasia of the corpus callosum and hypoplasia of the cerebellum has also been described in a domestic cat .…”