Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials

Windriyati, Yulias Ninik; Matsniyyatul, Badriyah; Kusumaningtyas, Diar Arum; Riesmalia, Rian Lesta

doi:10.22146/ijp.1138

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Although various techniques were reported to improve the drug's solubility (Sudibyo et al, 2020;Windriyati et al, 2020), the use of the spraydrying method employing water-soluble carriers, considered a novel approach for addressing solubility issues, has not yet been reported for mangiferin extract derived from mango leaves. The primary objective of this study was to explore the optimization of a spray-drying powder formulation derived from mango leaves.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment

Nguyen,

Vo,

et al. 2024

Indonesian J Pharm

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Mangiferin is known as a major compound in mango leaves with various pharmacological effects such as antioxidant, antiviral, cancer, diabetes,... However, the poor solubility of mangiferin limits its pharmaceutical applications. Thus, this work’s major goal was to optimize the parameters of the spray-drying process in order to improve the dissolution of mangiferin in Mangiferin indica L. leaf extract and capsule formulation for diabetes treatment. Fourteen experiments were designed with Design Expert software and optimized process formulas with BC Pharsoft OPT software. Three independent variables were selected for surveying namely the ratio of mangiferin to excipients (X1), the ratio of maltodextrin in spray fluid composition (X2), and inlet air temperature (X3). The dissolution of mangiferin was shown as the percentage of this compound released within 5 minutes (Y1), 15 minutes (Y2), 30 minutes (Y3), and the percentage of hygroscopicity at 25oC (Y4). The results showed that the optimized spray drying process and formula which included the ratio of mangiferin and maltodextrin in the spray drying solution being 8.30% and 9.63%, respectively, the inlet air temperature of 156.26oC, blowing speed of 50 m3/s, pump flow of 3 mL/min possessed the dissolution of mangiferin in spray drying powder of 91.89 ± 2.43% at 30 minutes, the percentage hygroscopicity of 0.13 ± 0.13% at 25oC. The cause-effect relations and optimization of Mangiferin indica L leaf extract powder formulation were investigated and reported for the first time. The spray-dried powder capsule released more than 90% active ingredients in 30 minutes and showed significant hypoglycemic effects in inhibiting the α-glucosidase enzyme (IC 50 of 36.94 µg/mL equivalent to mangiferin in comparison with the commercial drug Glucobay (acarbose 176.09 µg/mL). In summary, the capsules containing the optimized formula of mangiferin spray-dried powder from Mangifera indica L. leaf extract have been successfully prepared and had potential antidiabetic effects in in-vitro settings.

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Section: Introductionmentioning

confidence: 99%

Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment

Nguyen,

Vo,

et al. 2024

Indonesian J Pharm

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Principles, Applications and Limitations of the Liquisolid System of Drug Delivery: A Review

Effiong,

Onunkwo

2024

Trends Med. Res

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The liquisolid system of drug delivery continues to find usefulness as a potent means to circumvent solubility and dissolution challenges commonly encountered during drug formulation and medicine development in the pharmaceutical industry. Originally invented by Spireas, the technique has gained acceptance and improved over the years, in the types of excipients used, nature and class of drug formulated and its applications not only in transforming lipophilic and poorly soluble drugs to solid dosage forms with enhanced bioavailability, but also now gaining popularity in modified delivery, photoprotection and minimizing the effect of pH on drug release. This review thus highlights the foundational principles of the liquisolid technique, examines current methods employed and modern applications of this technique. It also gives present knowledge of this delivery technique and its limitations. A systematic approach to the search of published literature in standard databases (Pubmed, Google Scholar, Researchgate) was carried out using specific search terms and operators that provided available works as information sources for this review. Critical evaluation of obtained literature from the database was adopted to extract data on the principles and current applications of the liquisolid systems beyond its intended initial use. The prevailing mechanism for enhancing bioavailability via the technique is improved wetting and drug presentation in well dispersed or soluble state; minimal pH influence is based on the phenomenon of saturation solubility of the drug in the nonvolatile vehicle; and photoprotection is due to high refractive and diffraction capacities of the coating materials used. This work concludes by presenting the identified and potential limitations of the liquisolid technique. It gives expert opinions on how these are being circumvented and future perspectives on this ever-unfolding promising drug delivery strategy. It will be an invaluable contribution to current literature in drug development research employing liquisolid techniques for drug delivery.

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The Role of Excipients in Liquisolid Technology

Sharma¹

2022

CGCIJCTR

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This article gives criteria for choosing excipients in liquisolid technology. Liquisolid technology is applicable for non polar drugs by converting drug solution into dry free flowing powder. Patient compliance is more in oral route of administration .Numerous techniques like solid dispersion, micronisation, lyophilisation co-grinding, co-precipitation,complexation and nanotechnology are used to increase aqueous solubility Solid dispersion having stability issues while micronization and complexation can cause agglomeration. In Nanotechnology, high cost involved in sophicticated instruments. Liquisolid technology is considered to be one of the best technique to to overcome solubility,dissolution and bioavailability. It convert drug solution into dry free flowing powder. This technique is simple manufacturing process with low production cost. In vitro release is enhanced by using this technology. There is significant role of excipients in this novel technique to get effective release of drug. Associated problems of BCS class II and IV is mostly solved in respect to solubility. Especially carrier with high specific surface area gives good results in overcoming all challenges. Carriers such as Lactose, Starch, Avicel pH101,Fujacilin, Neusilin ,each having specific properties in release of drug. Among all mostly used carriers are Avicel, Fujacilin and Neusilin as with highest Specific Surface Area (SSA) than others. PVP and SSG is considered best disintegrating agent as having good swelling property and flow property as Polyvinypyrrolidine can be used in high dose drugs. With large SSA and high adsorptive property Neusilin, Aerosil , PVP as carrier, coating material and disintegrating agent are considered perfect excipients in liquisolid technology.

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Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials

Cited by 3 publications

References 12 publications

Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment

Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment

Principles, Applications and Limitations of the Liquisolid System of Drug Delivery: A Review

The Role of Excipients in Liquisolid Technology

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