Liquid-phase synthesis of 4-vinyl-1H-1,2,3-triazoles based on polyethylene glycol supported but-3-ynyl sulfonate

Abstract

An efficient liquid-phase synthesis of 4-vinyl-1H-1,2,3-triazole derivatives is developed from soluble polyethylene glycol (PEG) supported but-3-yn-1-yl sulfonate. This procedure affords the target compounds in moderate-to-excellent yields (58-91%) with mild reaction conditions and a facile work-up procedure.