Liquid membrane electrode for selective determination of salicylate in pharmaceutical preparations

Hassan, Saad S. M.; Hamada, Marawan A.

doi:10.1039/an9881301709

Cited by 32 publications

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“…An advantage of this electrode is that the anion ClO 4 -, different from what it is observed for the salicylate-sensitive liquid-membrane electrodes 13,14,26 does not interfere in its response. In quantitative studies about equilibria in solution, it is utilized an excess of inert electrolyte, so that the ionic strength of the solution is kept effectively constant during all the time encompassed by the experiments.…”

Section: Characteristics Of the Electrodementioning

confidence: 99%

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An Electrode of the Second Kind for Aspirin Determination in Tablet Formulations

et al. 1999

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Salicylate and its analogues, such as acetylsalicylate (aspirin) are commonly used as with effective analgesics, and are available to the public in a wide variety of formulations. Aspirin, a prostaglandin biosynthesis inhibitor, is also an important antipyretic drug. Recently, a new therapeutic use has emerged based on its unique antiplatelet aggregation property, so that aspirin is now being widely used to treat cardiovascular complications. 1 Although gas and liquid chromatographic methods are the most specific methods for salicylate 2,3 , but their general availability, especially for emergency use, is limited and probably not necessary. 4,5 Official methods, namely those proposed by the British Pharmacopoeia 6 , are usually based on time-consuming and tedious titrimetric procedures, which in themselves, justify the search for speedier methods. Direct potentiometric methods, however, are simpler and faster. In this context, the construction and analytical applications of electrodes that are sensitive to salicylate ion have been described.Most salicylate ion-sensitive electrodes use a liquid sensor immobilized in a porous membrane of Orion electrode series 92-20. 7-14 This fact restringes its utilization due to manipulation difficulty and the mechanical deficiency of this kind of setting up. With the evolution of ion-selective electrodes, in its brief history and development, other kinds of salicylate ion-sensitive electrodes has been described in the literature. [15][16][17][18][19][20][21][22][23][24][25][26] This paper describes for the first time the behavior and use of an electrode of the second kind, Pt|Hg|Hg 2 (Salic) 2 , the sensor of which was immobilized in graphite. This electrode works according to a principle which is quite different from that associated with previously described electrodes. The experimental variables that contribute to this electrode response, the calculation procedures utilized to determine the calibration curves jointly with the evaluation of this performance for the assay of aspirin in tablets (after hydrolysis of acetylsalicylate acid to salicylate), are described. Experimental Materials and solutionsDistilled, deionized water and "grade A" glassware were used throughout. All of the chemicals employed were of analytical reagent grade. Carbonate-free sodium hydroxide solutions were standardized potentiometrically with acid potassium phthalate, and then stored in polyethylene bottles protected with soda-lime tubes. The perchloric acid solutions were standardized potentiometrically with standard sodium hydroxide solutions. A sodium salicylate stock solution was standardized potentiometrically with a standard perchloric acid solution. Stock solutions of sodium perchlorate were analyzed by evaporating and drying to constant mass at 120˚C.Mercurous salicylate was prepared by mixing, in aqueous solution, the corresponding nitrate with an excess of sodium salicylate. The resulting precipitate was filtered through a sintered glass funnel, washed Química-UNESP, C. P. 355, 14801-970, ...

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Section: Characteristics Of the Electrodementioning

confidence: 99%

“…[7][8][9][10][11][12][13][14] This fact restringes its utilization due to manipulation difficulty and the mechanical deficiency of this kind of setting up. With the evolution of ion-selective electrodes, in its brief history and development, other kinds of salicylate ion-sensitive electrodes has been described in the literature.…”

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confidence: 99%

An Electrode of the Second Kind for Aspirin Determination in Tablet Formulations

et al. 1999

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“…The selectivity coefficients were determined by the separate solution method 20,21 in 0.05 mol dm -3 magnesium acetate using 1 × 10 -2 mol dm -3 concentration of both the scopolamine and interfering species. The selectivity coefficient was calculated from the following equation:…”

Section: Effect Of Diverse Ionsmentioning

confidence: 99%

Potentiometric PVC Membrane Sensor for the Determination of Scopolamine in Some Pharmaceutical Formulations

Mostafa

2002

ANAL. SCI.

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Tropane alkaloids, especially hyoscyamine and scopolamine, are widely used in medicine because of their strong parasympatholytic actions. Recently, it has been demonstrated that the alkaloid pattern can be shifted towards scopolamine when introducing the 6h6 gene which is involved in the biosynthesis of scopolamine from hyoscyamine.1,2 Scopolamine is a tropane alkaloid from solanaceous plants, and is used as an anti-convulsant, an anti-emetic, and an anti-parkinsonism; sedative-scopolamine was also evaluated as possible diagnostic agents for dementia.Several analytical techniques have been reported for the quantitative determinations of scopolamine. Among these are high-performance liquid chromatography (HPLC), 3-5 capillary zone electrophoresis, 6 proton nuclear-magnetic resonance spectroscopy, 7 gas chromatography mass-spectrometry (GC-MS), 8 micellar electrokinetic chromatography, 9 enzymeimmunoassay, 10 and potentiometry. 11 Most of these methods involve several time-consuming manipulation steps and require sophisticated instruments.Potentiometric methods using ion-selective electrodes have found wide application, 12-16 being simple, economical, and applicable over a wide range of different areas, and offer sufficient selectivity towards the drug in the presence of various pharmaceutical excipients. 17 A membrane electrode for the determination of scopolamine using scopolamine-tetraphenylborate 11 as an electroactive material was reported. The response of the electrode was linear for 0.02 -100 mmol dm -3 , with a response time of 15 s with a detection limit of 4 µmol dm -3 .The present work describes the preparation, characterization and some possible applications of a novel scopolamine PVC sensor based on the use of a scopolamine-phosphotungstate ionpair complex as the electroactive material and dioctylphthalate or o-nitrophenyloctyl ether as a placticizer. The sensitivity and stability offered by this simple electrode configuration are sufficient high to allow an accurate determination of low levels of scopolamine. Selectivity coefficient measurements by many cations and anions are negligibly small. ExperimentalApparatus All potentiometric measurements were made at 25 ± 1˚C, unless otherwise stated, using an Orion pH/mV meter (Model 330). A combined Ross glass pH electrode (Orion 81-02) was used for pH measurements. An Orion double-junction Ag-AgCl reference electrode (Model 90-02) containing 10% (w/v) potassium nitrate in the outer compartment was used. Reagents and materialsAll chemicals used were of analytical reagent grade, unless otherwise stated. Doubly distilled water was used throughout. Polyvinyl chloride powder (PVC) of high molecular weight, dioctylphthalate (DOP), o-nitrophenyloctyl ether (ONPOE), and tetrahydrofurane (THF) of purity >99% were obtained from Aldrich Chemical Company. Scopolamine hydrobromide, sodium tetraphenylborate, and phosphotungstic acid were obtained from BDH. Scopolamine injection (1 mg/cm 3 ) and ophthalmic solutions (0.25%) were obtained from Ciba Vision (Niederwagen, S...

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“…The selectivity coefficients were determined by the separate solution method 25,26 in acetate buffer of pH 6.0 using 10 -2 mol l -1 test solutions. Where E1 and E2 are the potential readings observed after 1 min of exposing the sensor to the same concentration of surfactant (aCP) and interference (aj 1/z ) respectively, S is the slope of the calibration graph (mV/concentration decade) and z is the charge of ion j.…”

Section: Effect Of Diverse Ionsmentioning

confidence: 99%

PVC Matrix Membrane Sensor for Potentiometric Determination of Cetylpyridinium Chloride

Mostafa

2001

ANAL. SCI.

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Liquid membrane electrode for selective determination of salicylate in pharmaceutical preparations

Cited by 32 publications

References 0 publications

An Electrode of the Second Kind for Aspirin Determination in Tablet Formulations

An Electrode of the Second Kind for Aspirin Determination in Tablet Formulations

Potentiometric PVC Membrane Sensor for the Determination of Scopolamine in Some Pharmaceutical Formulations

PVC Matrix Membrane Sensor for Potentiometric Determination of Cetylpyridinium Chloride

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