PVC Matrix Membrane Sensor for Potentiometric Determination of Cetylpyridinium Chloride

Mostafa, Gamal A. E.

doi:10.2116/analsci.17.1043

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…Cationic surfactant ion sensors based on ion exchanging, like the ion-association reaction, were also useful to reduce the solvent. [7][8][9][10] A typical carbon paste electrode (CPE), in which carbon powder is intimately mixed with a pasting liquid, has a surface that is essentially coated with a microfilm of the pasting liquid. 11,12 Several investigations have been reported, in which the characteristics of CPEs are described, along with the chemical and topographical heterogeneity of CPEs.…”

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Adsorptive Voltammetry of 2-(5-Bromo-2-pyridyl)azo-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol on a Carbon Paste Electrode in the Presence of Organic Cations and Polycation

et al. 2006

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The adsorption of ion-association complexes on a carbon paste electrode (CPE) was investigated by cyclic voltammetry using an electroactive hydrophobic anion probe. The redox reactions of 2-(5-bromo-2-pyridyl)azo-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol (5-Br-PAPS), the analytical probe, were irreversible. The reduction of the azo group and the oxidation of the phenol were observed at -0.1 V and 0.9 V vs. SCE, respectively, in a 0.1 mol L -1 H2SO4 solution. The peak currents for the redox reaction increased with the concentration of the cationic surfactant and the accumulation time. The increase in the ratio of the peak current to the concentration of cationic surfactants was proportional to the hydrophobicity. The peak current for 5-Br-PAPS also increased when a polycation, polyhexamethylene biguanide hydrochloride, was added and was strongly dependent on the ionic strength and pH, in contrast to cationic surfactants.

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Adsorptive Voltammetry of 2-(5-Bromo-2-pyridyl)azo-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol on a Carbon Paste Electrode in the Presence of Organic Cations and Polycation

et al. 2006

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“…Para efeitos de comparação e por não existir nenhum método oficial aplicado à análise deste tipo de produtos, incluem-se igualmente na Tabela (1,10 ± 0,03) x10 concentrações dentro da faixa linear revelaram em todos os casos a obtenção de valores de recuperação médios de 98 ± 3%. Estes resultados permitiram confirmar a boa exactidão do procedimento proposto, aspecto que confirma o bom desempenho analítico da potenciometria já evidenciado anteriormente por outros autores 24,25 .…”

Section: Análise De Amostras Reaisunclassified

“…Embora sob o ponto de vista ambiental a sua determinação seja menos importante que a dos surfactantes aniónicos 2 é conveniente o seu controlo analítico nos produtos comerciais referidos. Para a determinação de surfactantes catiónicos são descritos diversos procedimentos baseados na utilização de métodos volumétricos 3,4 espectrofotométricos 5-7 , cromatográficos [8][9][10] , electroforese capilar 11,12 e potenciométricos [13][14][15][16][17][18][19][20][21][22][23][24][25] . Estes últimos, aplicados de forma geral à determinação indirecta de surfactantes catiónicos em soluções desinfectantes oferecem como vantagens a determinação rápida, a preparação simples das amostras, a elevada sensibilidade e um grau de selectividade que conduz à obtenção de resultados mais exactos 26,27 .…”

Section: Introductionunclassified

Determinação potenciométrica em fluxo de cloreto de cetilpiridinio em desinfectantes bucais

Baptista¹,

Araújo²,

Montenegro³

2003

Quím. Nova

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Recebido em 27/5/02; aceito em 10/12/02 POTENTIOMETRIC DETERMINATION OF CETYLPYRIDINIUM CHLORIDE IN ORAL DESINFECTANTS BY FLOW INJECTION ANALYSIS. The work describes a new procedure for cetylpyridinium chloride determination in oral disinfectants, based on a flow-injection system with potentiometric detection. The determination was based on the measurement of picrate concentration decrease as result of ion-pair reaction with the analyte present in the injected sample. In the optimised set-up the sample injection volume was kept at 400 µL and merged downstream with the reagent solution containing 1,0 x10-5 mol/L of picrate adjusted to pH 5.0 with citrate/citric acid buffer. The flow rate was fixed at 8 mL/min and the reactor length at 40 cm. The proposed procedure enables the determination of cetylpyridinium in the analytical range of 5,0x10-6 -7,5x10 -5 mol/L at a sampling rate of 60/h. The results for real samples had a precision better than 3% and were comparable to the labelled values.Keywords: potentiometry; oral disinfectants; FIA. INTRODUÇÃOOs surfactantes catiónicos encontram uma grande aplicação em diversas indústrias destacando-se a química (pesticidas), papel, têx-til, plásticos e tintas. Além disso, são frequentemente usados na preparação de produtos de limpeza doméstica e de higiene pessoal 1 nomeadamente em desinfectantes bucais, pastas dentífricas, cremes de barbear, champôs e desodorizantes, por possuírem, para além de outras, propriedades anti-sépticas. É o caso do cloreto de cetilpiridinio, também designado por cloreto de hexadecilpiridinio que apresenta acção antimicrobiana, sobre bactérias gram negativas e que frequentemente é utilizado em fórmulas desinfectantes bucais. Embora sob o ponto de vista ambiental a sua determinação seja menos importante que a dos surfactantes aniónicos 2 é conveniente o seu controlo analítico nos produtos comerciais referidos. Para a determinação de surfactantes catiónicos são descritos diversos procedimentos baseados na utilização de métodos volumétricos 3,4 espectrofotométricos 5-7 , cromatográficos 8-10 , electroforese capilar 11,12 e potenciométricos [13][14][15][16][17][18][19][20][21][22][23][24][25] . Estes últimos, aplicados de forma geral à determinação indirecta de surfactantes catiónicos em soluções desinfectantes oferecem como vantagens a determinação rápida, a preparação simples das amostras, a elevada sensibilidade e um grau de selectividade que conduz à obtenção de resultados mais exactos 26,27 . O desempenho analítico dos eléctrodos selectivos de iões, poderá ainda ser incrementado recorrendo a métodos de fluxo contínuo, em particular à técnica Análise por Injecção em Fluxo (FIA). A eliminação da solução de referência interna dos eléctrodos tem possibilitado a sua construção com configuração tubular e incorporação em montagens FIA simples, fisicamente robustas, resultando em algumas situações a um aumento de reprodutibilidade das medidas 28 e da sensibilidade analítica (mV/dec) 29 e mais frequentemente a diminuição das interferências 30 . Estes aspe...

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“…[3][4][5] Potentiometric methods using ion-selective electrodes have wide applications [6][7][8][9][10][11] because they are simple, economical and available over a wide range of different areas, and offer sufficient selectivity towards the drug in the presence of various pharmaceutical excipients. The low cost, ease of use and maintenance, the simplicity and speed of assay procedure and the reliability of the analytical information make the ionselective electrodes very attractive for the assay of pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

et al. 2007

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IntroductionMebendazole (MBZ) (5-benzoyl-2-benzimidazolylcarbamic acid methyl ester) (C16H13N3O2) is a broad spectrum anthelmintic drug producing high cure rates in infestations by ascaris, thread worms, hook worms and whip worms.1,2 MBZ causes slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestines where helminths dwell.In recent years, potentiometric membrane sensors have been widely used in pharmaceutical analysis. [3][4][5] Potentiometric methods using ion-selective electrodes have wide applications 6-11 because they are simple, economical and available over a wide range of different areas, and offer sufficient selectivity towards the drug in the presence of various pharmaceutical excipients. The low cost, ease of use and maintenance, the simplicity and speed of assay procedure and the reliability of the analytical information make the ionselective electrodes very attractive for the assay of pharmaceutical products.The different analytical techniques available in the literature for the quantitative determination of MBZ include spectrophotometry, 12 high performance liquid chromatography, [13][14][15][16][17][18] liquid chromatography, 19 thin layer chromatography 20 and cathodic stripping voltammetry. 21 Most of these methods are complicated and need sophisticated instruments.In continuation to our work on drug analysis, 22-25 an attempt has been made to develop an electrochemical sensor for the anthelmintic drug mebendazole.The present work describes the fabrication, optimization and some possible applications of a novel MBZ PVC sensor based on the use of a mebendazole-silicotungstate ion pair complex as the electro active material and bis(2-ethylhexyl)phthalate (BEP) as plasticizer. The developed sensor displays high selectivity, long term stability, fast response and applicability over a wide range of pH and drug concentrations. Experimental Reagents and chemicalsAll chemicals used in the study were of highest purity available and were used without further purification. Polyvinyl chloride powder (PVC) of high molecular weight was supplied by Merck. Dibutyl sebacate (DBS), bis(2-ethylhexyl)phthalate (BEP), bis(2-ethylhexyl)adipate (BEA), bis(2-ethylhexyl)sebacate (BES), di-n-butyl phthalate (DBP), phosphotungstic acid (PTA), molybdophosphoric acid (MPA) and silicotungstic acid (STA) were purchased from Lancaster and used as received. Tetrahydrofuran (THF) was obtained from s.d. fine chemicals and all of the metal salts used (all from Merck) were of the highest purity available. Aqueous solutions of the salts were prepared by dissolving the appropriate salt or diluting standard solutions as specified in doubly distilled water. Aqueous solutions of the drug were freshly prepared by accurate dilutions of a standard 10 -1 M stock drug solution using dilute nitric acid (10% v/v) as solvent. Pure-grade MBZ was obtained as a gift sample. Pharmaceutical formulations containing MBZ were obtained from local drug stores....

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PVC Matrix Membrane Sensor for Potentiometric Determination of Cetylpyridinium Chloride

Cited by 19 publications

References 22 publications

Adsorptive Voltammetry of 2-(5-Bromo-2-pyridyl)azo-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol on a Carbon Paste Electrode in the Presence of Organic Cations and Polycation

Adsorptive Voltammetry of 2-(5-Bromo-2-pyridyl)azo-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol on a Carbon Paste Electrode in the Presence of Organic Cations and Polycation

Determinação potenciométrica em fluxo de cloreto de cetilpiridinio em desinfectantes bucais

Mebendazole Selective Membrane Sensor and Its Application to Pharmaceutical Analysis

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