Liquid formulation of minoxidil versus its foam formulation

Pürnak, Tuğrul; Şenel, Engin; Sahin, Ceren

doi:10.4103/0019-5154.84714

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Compared to MS, MF allows for increased delivery of the active ingredient to the target site and easy penetration of the drug with less irritation; hence, the US Food and Drug Administration (FDA) has granted approval for 5% MF for the treatment of AGA. MF is also more convenient to use, because it dries quicker and spreads less to the peripheral region 5…”

Section: Pharmacology Of Topical Minoxidilmentioning

confidence: 99%

<p>Minoxidil and its use in hair disorders: a review</p>

Suchonwanit

Thammarucha

Leerunyakul

2019

DDDT

255

165

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Minoxidil was first introduced as an antihypertensive medication and the discovery of its common adverse event, hypertrichosis, led to the development of a topical formulation for promoting hair growth. To date, topical minoxidil is the mainstay treatment for androgenetic alopecia and is used as an off-label treatment for other hair loss conditions. Despite its widespread application, the exact mechanism of action of minoxidil is still not fully understood. In this article, we aim to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.

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Section: Pharmacology Of Topical Minoxidilmentioning

confidence: 99%

<p>Minoxidil and its use in hair disorders: a review</p>

Suchonwanit

Thammarucha

Leerunyakul

2019

DDDT

255

165

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“…In the case of irritation or allergy from propylene glycol, a propylene-glycol-free formulation can be prescribed to reverse the sensitization process and enhance drug acceptability and tolerability [ 9 , 29 , 30 ]. In such cases, the foam form is preferred over the liquid form, as it does not contain any propylene glycol, usually required for the liquid formulation to serve as a vehicle that dissolves hydrophobic minoxidil in water [ 31 ]. Minoxidil-induced seborrhea and itching can also be treated by alternating between ketoconazole or zinc pyrithione or selenium-sulfide-based shampoos.…”

Section: Discussionmentioning

confidence: 99%

Compliance to Topical Minoxidil and Reasons for Discontinuation among Patients with Androgenetic Alopecia

Zari

2023

Dermatol Ther (Heidelb)

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Introduction: This study assessed the levels of compliance to topical minoxidil (TM) among male and female patients with androgenetic alopecia (AGA) and analyzed the factors associated with minoxidil discontinuation. Method: A retrospective study was conducted among 400 consecutive patients with AGA who presented to a dermatology clinic and who were prescribed minoxidil 2% or 5% in the past 5 years. Demographic factors, other previous treatments, and minoxidil parameters including the dose (2% or 5%), total duration of use, treatment results, and side effects were collected. Result: The mean age of the patients was 32.41 years [standard deviation (SD) 8.18], and 66.5% were female. The majority of patients (82.5%) did not receive any previous treatment for AGA. Of the total patients, 345 (86.3%) have discontinued minoxidil. Discontinuation rate showed no association with sex (p = 0.271), age

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“…The tendency of minoxidil to f yield insoluble crystalline form as the ethanol evaporates through application on the skin minoxidil topical solution shows inefficient uptake by the skin. Further, minoxidil has poor skin penetration ability which limits its usefulness as a potent treatment of the hair loss ( 3 5 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Physicochemical Evaluation of Benzoyl Peroxide 5% Foamable Emu oil Emulsion

Shatalebi

Roostaei

2015

Jundishapur J Nat Pharm Prod

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The aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose of improving minoxidil permeation into the skin, increasing hair growth, reducing skin irritation, and increasing consumer compliance. Minoxidil was dissolved in a solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). The foamable emulsion was prepared by mixing the oil phase with minoxidil solution using different amount of various emulsifiers. Seventeen formulations were prepared and the most stable foamable emulsion was selected and evaluated for various pharmaceutical parameters such as homogeneity, pH, stability to centrifugal stress, freeze-thaw and foamability. The adopted formulation showed good pharmaceutical characteristics. In vitro release rate of the formulations were evaluated using Franz diffusion cell using phosphate buffer pH 7.4 and ethanol as the receiver medium at sink condition. The release rate of formulations was found to obey Higuchi kinetic model. Experimental animal study was performed to evaluate hair growth potential of the formulation. Different cyclic phases of hair follicles, like anagen, and telogen phases, were determined at one month period. Histological study after treatment with adopted formulation exhibited greater number of hair follicles in anagenic phase (96%) which were higher as compared to marketed 5% minoxidil solution (Pakdaru® 70%) and the control group (42%). From animal study it was concluded that the selected formulation exhibited a significant potency in promoting hair growth in comparison with marketed 5% minoxidil solution Pakdaru®.

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Liquid formulation of minoxidil versus its foam formulation

Cited by 8 publications

References 8 publications

<p>Minoxidil and its use in hair disorders: a review</p>

<p>Minoxidil and its use in hair disorders: a review</p>

Compliance to Topical Minoxidil and Reasons for Discontinuation among Patients with Androgenetic Alopecia

Preparation and Physicochemical Evaluation of Benzoyl Peroxide 5% Foamable Emu oil Emulsion

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