Liquid chromatographic separation of positional isomers of suprofen on a cyclodextrin-bonded phase

Marziani, F.C.; Sisco, W.R.

doi:10.1016/s0021-9673(01)92682-2

Cited by 16 publications

(6 citation statements)

References 4 publications

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“…other molecules such as drugs (ibuprofen, suprofen, nomifensine) [295,296,303], quinones [257,259], organometallic compounds (ferrocene, ruthenocene, osmocene) [261,263,271], alkaloids (tobacco alkaloids, metabolites, nicotine) [275], flavonoids [259,301] carotenoids (retinoids) [299], proline [279], prostaglandins [291,292], alkylbenzyldimethylammonium [300], porphyrins [308], vitamins [257,266] or crown ethers [271,279] were studied. Anionic and cationic surfactants as well as inorganic ions can also be separated [257].…”

Section: Cyclobondm Phasesmentioning

confidence: 99%

Synthesis and applications of adsorbents containing cyclodextrins

Crini¹,

2002

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Synthesis and applications of adsorbents containing cyclodextrinsCyclodextrins (CDs), which possess a hydrophobic cavity, have a remarkable capacity to form inclusion complexes with various molecules through host-guest interactions. It is well known that the usefulness of CDs is due to the combination of the inclusion properties and structural features of these molecules. CDs are used extensively in separation science because CD-complexation phenomena offer a procedure of choice for separation of compounds and extraction processes, and provide a useful and versatile tool for protecting the environment. The present review shows the advantages accruing from the use of adsorbents containing cyclodextrins, in particular in chromatographic separations and in waste water treatment. The main goal of this review is to provide a summary of the information concerning the synthesis of materials containing CDs and to give a general overview of the different possible applications of CDs as sorbents in the field of separation techniques. Recent and continuing interest in these adsorbents is evident from the number of papers that appear each year in the literature.

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Section: Cyclobondm Phasesmentioning

confidence: 99%

Synthesis and applications of adsorbents containing cyclodextrins

Crini¹,

2002

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“…While it is possible to achieve the baseline separation of some isomers by RPC with alkylsilica columns, the use of a cyclodextrin column may be a better choice [39][40][41], as illustrated by the example of Figure 6.16. The enhanced isomer selectivity provided by cyclodextrin columns may be due to the presence of -OH groups in the cyclodextrin molecule (allowing for hydrogen bonding between solute and column).…”

Section: Enhanced Isomer Selectivitymentioning

confidence: 99%

Reversed‐Phase Chromatography for Neutral Samples

Snyder

Kirkland

Dolan

2009

Introduction to Modern Liquid Chromatography

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“…Thus, Geisslinger et al [73] usedcyclodextrin chiral stationary phase (Cyclobond I) for the separation of ibuprofen. Marziani and Sisco [74] also used Cyclobond I with 70% acetonitrile, containing 0.1% of triethylamine (pH 4.5) for the separation of suprofen. Furthermore, Wsol et al [75] applied Cyclobond I 2000 RSP (containing -cyclodextrin derivatized with R,Shydroxypropyl groups) and ESPhCD ( -cyclodextrin derivatized with phenylcarbamate) columns to separate flobufen enantiomers.…”

Section: Chiral Separation On Cyclodextrin Cspsmentioning

confidence: 99%

Supramolecular Chiro-Biomedical Assays and Enantioselective HPLC Analyses for Evaluation of Profens as Non-Steroidal Anti-Inflammatory Drugs, Potential Anticancer Agents and Common Xenobiotics

Ali¹,

Hussain²,

Saleem³

et al. 2008

CDDT

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The permanent world-wide increase in therapeutic administration of racemic profens as easy available non-prescribed analgesic drugs and a common first-choice anti-inflammatory agents was recently linked with renewed interest in their beneficial use, also as enantiopure formulations, to treat and/or prevent a variety of human malignancies including its four major types as colorectal, breast, lung, and prostate cancer. This underlies the continuous need of selecting perfectly suited chiral separation methods of profens capable to determine nanolevels of a distomer in presence of the eutomer in a variety of complex biological and environmental media. Thus, current improvements for direct enantiomeric separations of profens by well defined supramolecular-based chiral HPLC and recently developed monolithic, combinatorial, bimodal and polymeric chiral stationary phases employing a modern supramolecular chirality concepts has been outlined in this review. The use of diverse supramolecular approaches for chiral HPLC as an easy accessible tool enabling fast development of nanoscale enantioselective, high-throughput and gradient screening procedures for in situ monitoring of stereoselective ADME properties of profens in range of anticancer drug discovery technologies has been also addressed.

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Liquid chromatographic separation of positional isomers of suprofen on a cyclodextrin-bonded phase

Cited by 16 publications

References 4 publications

Synthesis and applications of adsorbents containing cyclodextrins

Synthesis and applications of adsorbents containing cyclodextrins

Reversed‐Phase Chromatography for Neutral Samples

Supramolecular Chiro-Biomedical Assays and Enantioselective HPLC Analyses for Evaluation of Profens as Non-Steroidal Anti-Inflammatory Drugs, Potential Anticancer Agents and Common Xenobiotics

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