Liquid Carbon Dioxide Extraction of Xanthones from the Pericarps of &lt;i&gt;Garcinia Mangostana&lt;/i&gt; Linn. Enhanced by Ultrasonic Irradiation

Mishima, Kenji; Kawamura, Hirofumi; Itô, Shota; Inoue, Yuuta; Hirota, Takako; Kato, Takafumi; Sharmin, Tanjina; Kawakami, Ryo; Irie, Keiichi; Mishima, Kenichi; Harada, Takunori; Mustofa, Salim; Hasanah, Fauziyah; Siregar, Yusraini Dian Inayati; Putri, Lily Surayya Eka; Salim, Agus

doi:10.15261/serdj.22.187

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Taps are opened on the gas cylinder (6) and the control panel (2), and gas flows from the cylinder to the internal space until the pressures inside the cylinder and reactor equalize. The pump (7) then raises the pressure to the required level, and the line from the control panel to the reactor is closed. Afterwards, the tap on the cylinder is closed as well.…”

Section: Methodsmentioning

confidence: 99%

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Ultrasound-Assisted Cold Pasteurization in Liquid or SC-CO2

et al. 2021

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Various types of chemical and physical protocols are used, thermal treatment in particular, to increase the quality of bulk food products (for example, dates or some sort of nuts) and extend shelf life, and combinations of methods are frequently used to achieve the best results. However, the use of these processing methods is not always the best option to preserve the initial taste and appearance of food products. For instance, a product may lose its initial natural appearance and acquire different flavors due to chemical transformations that occur at certain temperatures or when the products are treated with chemicals. Non-thermal treatment methods are called “cold” pasteurization. This is a set of advanced techniques that are based on physical and chemical effects that do not result in the structural food-product transformations caused by heating. We have developed and tested a new technique for efficient food-product processing and cold pasteurization in an ultrasonic field under pressure in an atmosphere of supercritical or subcritical carbon dioxide. A laboratory-scale unit that was designed and built for this purpose has experimentally proven the feasibility of this process and demonstrated high efficiency in suppressing pathogenic flora.

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Section: Methodsmentioning

confidence: 99%

“…The potential of carbon dioxide applications for extraction has been well-studied [7][8][9][10]. Studies of the effect of ultrasound (US) on extraction processes have shown that the penetrating power of carbon dioxide increased under the effect of US both in the subcritical and supercritical states.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Cold Pasteurization in Liquid or SC-CO2

et al. 2021

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“…This is due to the high content of bioactive metabolites such as xanthones, triterpenes, and benzophenones (Nguyen et al, 2005;Mohamed et al, 2014). However, most of the earlier research in mangosteen has mainly focused on xanthones without much emphasis on other potential bioactive metabolites in mangosteen fruit pericarp including primary metabolites (Sukatta et al, 2013;Mishima et al, 2015;Yoswathana and Eshtiaghi, 2015). Hence, further study to profile mangosteen metabolome from the pericarp and optimizing its extraction methods are needed, particularly using the metabolomics approach.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics analysis of mangosteen (Garcinia mangostana Linn.) fruit pericarp using different extraction methods and GC-MS

Mamat¹,

Azizan²,

Baharum³

et al. 2018

Plant Omics

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Garcinia mangostana Linn. (mangosteen) reportedly contains several bioactive metabolites which have been used in various traditional disease treatment, nutritional supplement and skincare products. However, reports detailing its characterization and metabolite content are still scarce. Most of the earlier reports only focused on the extraction of specific metabolites such as xanthones and anthocyanins, rather than a comprehensive metabolome profile. In this study, global metabolomics approach using gas chromatography-mass spectrometry (GC-MS) analysis was conducted to profile the metabolite content of mangosteen fruit pericarp harvested at the final stage of ripening (dark purple stage). Five different extraction methods, which vary in their solvent mixtures, solvent ratios, with or without sonication were compared, aimed to maximize metabolite detection from the mangosteen tissue. The results showed that the method using a combined solvent mixture of methanol/chloroform/water (3:1:1 v/v ratio) with sonication has consistent reproducibility amongst biological replicates and successfully yielded the highest number of metabolites compared to the other methods. By combining the results of different extraction methods, we tentatively identified a total of 73 metabolites comprising of sugars (49.32%), alcohols (9.59%), sugar acids (8.22%), organic acids (6.85%), phenolic acids (5.48%), aromatic compounds (2.74%) and aldehyde (1.37%). This finding provides an overview of the metabolite content of mangosteen pericarp and comprehensive assessment of extraction methods for an untargeted metabolomics approach of this beneficial fruit.

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“…SC-CO2 is excellent extraction solvent for the non-polar substance because it has properties similar to hexane. Additionally the method has shown high selectivity by operating conditions such as temperatures and pressures [13][14][15]. However, it is necessary to use a special apparatus to establish the high pressure of SC-CO2 and pretreatment such as sample drying.…”

Section: Introductionmentioning

confidence: 99%

Functional Ingredients Extraction from Garcinia mangostana Pericarp by Liquefied Dimethyl Ether

Nerome

Hoshino

Itô

et al. 2016

Self Cite

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Abstract. The mangosteen (Garcinia mangostana Linn.) pericarp contains rich xanthone, a one kind of the polyphenols in the non-edible portion. In recent years, xanthones have been noted as a functionality such as anti-cancer effect and is expected as pharmaceuticals and health supplements. In this work, extraction of xanthones from mangosteen pericarp by using liquefied DME were investigated. Wet powder and cube samples were used as a raw material. Experimental conditions were 35 °C, 0.8 MPa with various amounts of sample (1, 3, 6 g). Extracted components were analyzed by using high performance liquid chromatography (HPLC). As a result, it was confirmed that eight kinds of xanthones such as alpha-mangostin, 3-Isomangostin, Mangostanol, 8-Desoxygartanin, Gartanin, Garcinone E, 9-Hydroxycalabaxanthone, beta-Mangostin were extracted. The highest yield of alpha-mangostin (42.9 mg/g_dry sample) was obtained with a powder sample of 6 g loaded. Final alpha-magostin corresponded to about 104% of the ethanol extraction with wet mangosteen pericarp, and 72% of the dried sample. Therefore, it was considered that in the extraction of xanthones from the mangosteen, liquefied DME extraction was valid.

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Liquid Carbon Dioxide Extraction of Xanthones from the Pericarps of <i>Garcinia Mangostana</i> Linn. Enhanced by Ultrasonic Irradiation

Cited by 3 publications

References 26 publications

Ultrasound-Assisted Cold Pasteurization in Liquid or SC-CO2

Ultrasound-Assisted Cold Pasteurization in Liquid or SC-CO2

Metabolomics analysis of mangosteen (Garcinia mangostana Linn.) fruit pericarp using different extraction methods and GC-MS

Functional Ingredients Extraction from Garcinia mangostana Pericarp by Liquefied Dimethyl Ether

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