Liquid Bandage (2-Octyl Cyanoacrylate) as a Temporary Wound Barrier in Clear Corneal Cataract Surgery

Meskin, Seth W.; Ritterband, David C.; Shapiro, Daniel; Kusmierczyk, Jaroslaw; Schneider, Susan; Seedor, John A.; Koplin, Richard S.

doi:10.1016/j.ophtha.2005.05.014

Cited by 41 publications

(24 citation statements)

References 35 publications

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“…This model was further tested in vivo on patients after cataract surgery. The case study proved the safety and efficacy of 2-octyl-cyanoacrylate as a watertight sealant for wound closure after cataract incision [25].…”

Section: Sealing Corneal Cataract Woundsmentioning

confidence: 76%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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Section: Sealing Corneal Cataract Woundsmentioning

confidence: 76%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…After the cataract surgery and before the application of the adhesive, all incisions were hydrated with a balanced saline solution and were examined for leakage by applying gentle pressure to the wound with a cellulose sponge. Out of the 51 eyes, seven of the eyes displayed leakage [11]. There was no leakage present in all 51 eyes when the adhesive was applied.…”

Section: Focusmentioning

confidence: 89%

“…As shown in Table 6, cyanoacrylate displayed the greatest adhesive strength over gelatin-based adhesive and fibrin [38]. and blood [10,11]. Upon contact with liquid substances, a strong bond is formed between the adhesive and tissue.…”

Section: Tensile Strengthmentioning

confidence: 96%

“…Upon contact with liquid substances, a strong bond is formed between the adhesive and tissue. The application of one drop of 2-octyl cyanoacrylate as a smooth single layer on the wound takes 15 to 30 s to fully polymerize and dry [11]. When increasing the droplet amount of 2-octyl cyanoacrylate to two to three drops, it takes two minutes to fully polymerize and dry as a thin, uniform layer on the wound [10].…”

Section: Tensile Strengthmentioning

confidence: 99%

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Characterization of silver nanoparticle-infused tissue adhesive for ophthalmic use

Yee

Selvaduray

Hawkins

2016

Journal of the Mechanical Behavior of Biomedical Materials

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This research examined if the infusion of silver nanoparticles into a 2-octyl cyanoacrylate tissue adhesive alters the antibacterial effectiveness and mechanical properties of the adhesive. Silver nanoparticle size and concentration combinations were varied to determine the effects of these factors. Uniform distribution of the silver nanoparticles was achieved before proceeding to testing. Antibacterial effectiveness of the composite adhesive was determined via the Kirby-Bauer disk diffusion susceptibility test and by CFU counting. Doping the adhesive with silver nanoparticles resulted in an order of magnitude reduction in bacterial growth. The greatest antibacterial effect came from imbuing 10 μg/mL of 4 nm silver nanoparticles into the tissue adhesive. Despite the noticeable reduction of bacterial growth for the doped adhesives, the difference among the varying silver nanoparticle size and concentration combinations was minimal.The breaking strength of the adhesive increased when silver nanoparticles were added. The adhesive strength of the composite adhesive attached to an incised porcine sclera was also greater than the unaltered adhesive. The greatest breaking load and adhesive force was the 10 μg/mL of 10 nm silver nanoparticle-doped adhesive. The

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“…Cyanoacrylates are liquid monomers that can polymerize rapidly to form a strong adhesive (10) . These polymers have been used with apparent safety and efficacy in ophthalmologic applications for more than 30 years (11) . During this time, numerous reports have described their use in the cornea, sclera, eyelid skin grafts, mucous membrane grafts in socket reconstruction and daily application to treat severe blepharoptosis (12)(13)(14)(15) .…”

Section: Introductionmentioning

confidence: 99%