Lipoxygenases and their metabolites in formation of plant stress tolerance

Lipoxygenase activity in ontogenesis of ferns Salvinia natans and Polystichum aculeatum

“…Activity of 9-LOX is typical of the higher plant root system where the enzyme is localized in cell cytosol. In higher plants 9-hydroperoxides of PUFAs are predecessors of compounds that stimulate the synthesis of ketoles, which induce flowering, provide coloration of flowers, defense and programmed cell of leaves affected by pathogens and regulate tubirization [3]. Activity of 9-and 13-LOX varies depending on a phenological phase of e. arvense sporophyte development that coincides with data obtained on S. natans and P. aculeatum.…”

“…These compounds are involved in the regulation of growth, development as well as formation of responses to environment signals and provide certain communication between living organism kingdoms [2, 3 7-10]. Search for specific DNA sequences in the data base GenBank, Refseq, Uniprot, Ensembl made it possible to establish the presence of LOX in ciano-and proteobacteria, the simplest unicellular red and green sea algae, amoeba, fungi, mosses, angiosperms and animals [1,3]. Although a biological role of LOX in lower plants remains unclear, the occurrence of LOX sequence in their DNA suggests that the genus of these enzymes is evolutionary ancient and emerged after the emergence of oxygen on the Earth.…”

“…4). Oxylipins -metabolites of the allene oxide synthase branch of LOXpathway, particularly JA and its methyl alcohol, are known to promote fruit maturation [3,10,28,29].…”

“…Lipoxygenases molecules (linoleate:oxygen oxydoreductase, EC 1.13.11.12, LOXs) contain non-gem iron [1][2][3] and catalyze stereo-specific peroxidation of polyunsaturated fatty acids (PUFA) that have at least one 1Z,4Z-pentadiene link [4]. Formation of hydroperoxides of trans-and cis-conjugated dienes is a key reaction in the lipoxygenase cascade that initiates seven enzyme branches [5], whose final products are biologically active metabolites -oxylipins [5,6].…”

Conserved structural and dynamic aspects behind Ohr enzymatic catalysis: Ohr as potential drug targets

“…Drug Targeting LOX and COX are recognized therapeutic valuable options against inflammatory diseases such as arthritis, rheumatisms, asthma and as diary plain relievers (Mashima & Okuyama, 2015;Zarghi & Arfaei, 2011;Schneider et al, 2007). Furthermore, LOX and the peroxidation of fatty acids are essential for plant cell mechanisms of adaptation against many abiotic stressor effects such as, drought, frosts, temperature variation, high humidity, pesticide pollution and herbivory insects (Woldemariam et al, 2018;Babenko et al, 2017;Santino et al, 2013).…”