Liposomes Size Engineering by Combination of Ethanol Injection and Supercritical Processing

Efficient encapsulation of proteins in submicro liposomes using a supercritical fluid assisted continuous process

“…At the end of this process, droplets fall in the continuous water pool located at the bottom of the vessel and a water in water emulsion is formed; i.e., liposomes of controlled dimension could be formed with high encapsulation efficiencies. Liposome suspension produced using SuperLip process can be purified from ethanol residues using a supercritical method, as reported in a recent publication [35].…”

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

“…Owing to advantages such as mild process conditions (T c =304.1 K, P c =7.38 MPa), no organic solvent residues, and being environmentally benign, supercritical (sc) CO 2 has been used in preparing nanoplatforms recently. 7,8 Among several sc-CO 2 techniques, solution-enhanced dispersion by sc-CO 2 (SEDS) emerges as a novel nanotechnology due to its broad range in selection of biomaterials and drugs. In SEDS, a special coaxial nozzle is used to produce very small droplets and improve the mixing effect between compound solution and sc-CO 2 flow, in order to promote mass transfer.…”

Injectable PLGA/Hydroxyapatite/Chitosan Microcapsules Produced by Supercritical Emulsion Extraction Technology: An In Vitro Study on Teriparatide/Gentamicin Controlled Release

“…In this sense, supercritical fluid technologies may offer an improved control over the morphology and composition of microdevices and nanodevices coupled with good fabrication process robustness. [22][23][24][25] The basic idea of use supercritical carbon dioxide (SC-CO 2 ) as the extracting agent of the oily phase of an emulsion, leading solvent-free microspheres was proposed in 2006 26 ; the original process was performed using a batch operative layout, then was later improved by other authors and named supercritical emulsion extraction (SEE). [27][28][29] After these pioneering articles, new SEE continuous process layout was proposed using a countercurrent-packed tower to reduce the emulsion processing time (few minutes of residence time), improve the encapsulation efficiency (especially if double emulsions are treated), and assured higher process reproducibility.…”