Liposomes modified by mono- and bis-phthalocyanines: A comprehensive EPR study

Man, Dariusz; Słota, Rudolf; Kawecka, A.; Engel, Grzegorz; Dyrda, Gabriela

doi:10.1140/epje/i2017-11550-4

Cited by 6 publications

(3 citation statements)

References 30 publications

(37 reference statements)

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“…The so-called melting transition of a DOPC bilayer is -20 ºC whereas that of a DODAB one is 45 ºC, thus experiments were done at 25 and 50 ºC. From the data obtained in each spectra, the relaxation times can be calculated according to the methods proposed by Cruz et al [61] and Man et al [62]. Figure 9 shows the relaxation time values obtained as the number of polyelectrolyte layers increase for DOPC:DODAB liposomes with 70:30 compositional ratio, a similar qualitative trend was obtained for liposomes with 30:70 compositional ratio.…”

Section: Effect Of the Coating On The Liposome Membrane (Electron Spi...mentioning

confidence: 99%

Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes

et al. 2021

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This work presents a simple methodology for coating small unilamellar liposomes bearing different degrees of positive charge with polyelectrolyte multilayers using the sequential layer-by-layer deposition method. The liposomes were made of mixtures of 1,2-dioleyl-sn-glycero-3-phosphocoline and dimethyl dioctadecyl ammonium bromide (DODAB) and coated by alternated layers of the sodium salt of poly(4-styrenesulfonate) (PSS) and poly(allylamine) (PAH) as polyanions and polycations, respectively. The results show that the zeta potential of the liposomes was not very sensitive to the mole fraction of DODAB in the membrane, X D, in the range 0.3 ≤ X D ≤ 0.8. We were able to coat the liposomes with up to four polymer bilayers. The growth of the capsule size was followed by dynamic light scattering, and in some cases, by cryo-transmission electron microscopy, with good agreement between both techniques. The thickness of the layers, measured from the hydrodynamic radius of the coated liposome, depends on the polyelectrolyte used, so that the PSS layers adopt a much more packaged conformation than the PAH layers. An interesting finding is that the PSS amount needed to reach the isoelectric point of the capsules increases linearly with the charge density of the bare liposomes, whereas the amount of PAH does not depend on it. As expected, the preparation of the multilayers has to be done in such a way that when the system is close to the isoelectric point, the capsules do not aggregate. For this, we dropped the polyelectrolyte solution quickly, stirred it fast, and used dilute liposome suspensions. The method is very flexible and not limited to liposomes or polyelectrolyte multilayers; also, coatings containing charged nanoparticles can be easily made. Once the liposomes have been coated, lipids can be easily eliminated, giving rise to polyelectrolyte nanocapsules (polyelectrosomes) with potential applications as drug delivery platforms.

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Section: Effect Of the Coating On The Liposome Membrane (Electron Spi...mentioning

confidence: 99%

Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes

et al. 2021

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“…A liposome is a double-layered membrane structure formed spontaneously during the water phase by phospholipid molecules under hydrophobic forces. 29 , 30 The amphiphilic characteristics make it possible to load fat-soluble drugs between the double-layered membranes and to wrap water-soluble drugs in the center. Liposomes are highly biocompatible and degradable, reduce drug toxicity, and realize sustained drug release.…”

Section: Ocular Nano-drug Delivery Systemmentioning

confidence: 99%

Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective

Zhang¹,

Jiao²,

Niu³

et al. 2021

IJN

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The complex drug delivery barrier in the eye reduces the bioavailability of many drugs, resulting in poor therapeutic effects. It is necessary to investigate new drugs through appropriate delivery routes and vehicles. Nanotechnology has utilized various nano-carriers to develop potential ocular drug delivery techniques that interact with the ocular mucosa, prolong the retention time of drugs in the eye, and increase permeability. Additionally, nano-carriers such as liposomes, nanoparticles, nano-suspensions, nano-micelles, and nano-emulsions have grown in popularity as an effective theranostic application to combat different microbial superbugs. In this review, we summarize the nano-carrier based drug delivery system developments over the last decade, particularly review the biology, methodology, approaches, and clinical applications of nano-carrier based drug delivery system in the field of ocular therapeutics. Furthermore, this review addresses upcoming challenges, and provides an outlook on potential future trends of nano-carrier-based drug delivery approaches in ophthalmology, and hopes to eventually provide successful applications for treating ocular diseases.

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“…This technique, due to low invasiveness, has proven itself in measurements, where it is desirable to use the same sample many times [40][41][42]. Additionally, thanks to the use of spin probes located in different places of the bilayer, changes in the membrane in its cross-section can be examined [43][44][45]. The use of model membranes in research has the advantage of being able to control the processes that take place inside them under the influence of various factors.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Propanol, N-Butanol and Pentanol on Aqueous Dispersions of Sonicated Liposomes. EPR Study

Bartnikowska

Pytel

Man

2022

Ecological Chemistry and Engineering S

Self Cite

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This paper presents the effect of selected alcohols on the fluidity of liposome membranes obtained in sonication of DPPC lecithin. Using the EPR technique, the duality of propanol, n-butanol and pentanol on the behaviour of the aqueous dispersion of liposomes was demonstrated. It was shown that after exceeding a certain concentration, these alcohols initiate dispersion foaming, leading to phase separation: liposome dispersion - lipid foam. The influence of the shape of the molecule and the length of hydrocarbon chains on the effectiveness of destabilisation of the structure of lipid membranes was indicated.

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Liposomes modified by mono- and bis-phthalocyanines: A comprehensive EPR study

Cited by 6 publications

References 30 publications

Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes

Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes

Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective

The Impact of Propanol, N-Butanol and Pentanol on Aqueous Dispersions of Sonicated Liposomes. EPR Study

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