Liposomes in ultrasonic drug and gene delivery

Huang, Shaoling

doi:10.1016/j.addr.2008.03.003

Cited by 313 publications

(241 citation statements)

References 100 publications

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“…6 For example, liposomes sensitive to pH, 7,8 temperature, 9 magnetic fields, 10 redox potential, 11,12 light, 13,14 ultrasound, 15,16 or shear. 17 In our previous study, we developed a pH-responsive liposome, which uses an amino acid-based zwitterionic liposome containing 1,5-dihexadecyl N,Ndiglutamyl-lysyl-L-glutamate (GGLG) as the main lipid.…”

Section: Introductionmentioning

confidence: 99%

A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

Li¹,

Takeoka²

2013

IJN

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Section: Introductionmentioning

confidence: 99%

A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

Li¹,

Takeoka²

2013

IJN

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“…Liposomes possess both hydrophilic and hydrophobic regions which ensure the dissolution of sparingly watersoluble molecules within the lipid bilayer (8). Liposomes are able to serve as micro-reservoirs and improve the solubility of less water-soluble drugs such as diclofenac due to its controllable leakage characteristic, thus improving bioavailability and therapeutic index of encapsulated drug (9).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Anti-Inflammatory Effects of Nanoencapsulated Diclofenac

et al. 2013

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This study was conducted to compare the anti-inflammatory efficacy of nanoencapsulated and freeform diclofenac in rat. Diclofenac-Ioaded Iiposomes were prepared using the proliposome method. The anti-inflammatory effects ofnanoencapsulated and free diclofenac were evaluated using the carrageenaninduced paw edema, formalin-induced paw licking and cotton-pellet-induced granuloma tests in vivo. For carrageenan-induced paw edema, 2 and 20 mg/kg Iiposome-encapsulated diclofenac showed significant paw volume reduction compared to free form diclofenac of equivalent dosage groups. In the formalin test, significant reduction in paw-licking time was observed in late phase for both Iiposomeencapsulated and free-form diclofenac (2 and 20 mg/kg) with the percentage of inhibition of 28.62, 60.17% for free-form diclofenac and 31.45, 78.84% for Iiposome-encapsulated diclofenac, respectively. In cotton-pellet-induced granuloma test 20 mg/kg free-form diclofenac showed significant reduction in the size of granuloma in both transudative and granuloma weight with percentage of inhibition of 42.93 and 49.26%, respectively, when compared to controls. Interestingly, 20 mg/kg nanoencapsulated diclofenac showed a larger reduction of the parameter with percentage of inhibition of 48.43 and 63.55%, respectively. Collectively, these results indicated that nanoencapsulated diclofenac exhibited statistically higher efficacy than free-form diclofenac when orally administered. Hence, clinical dosage may be reduced thereby reducing the drug's adverse effects.

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“…Methods of preparing of polymeric nanoparticles have been reviewed 15, 61 and they include ionic gelation, coacervation, solvent evaporation, spontaneous emulsification/solvent diffusion, salting out/emulsification-diffusion, supercritical fluid technology and polymerization. Depending on the materials utilized, such as phospholipids and glycolipids, the desired liposome structure can be prepared by sonication, electroformation, extrusion from diluted lamellar dispersions, high-shear homogenization, reverse-phase evaporation, gel exclusion chromatography, freezelyophilization, calcium-induced fusion, detergent dialysis and ultracentrifugation [62][63][64][65] .…”

Section: Methods Of Fabricationmentioning

confidence: 99%