A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

Li, Tianshu; Takeoka, Shinji

doi:10.2147/ijn.s47749

Cited by 17 publications

(6 citation statements)

References 26 publications

(34 reference statements)

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“…These are extremely interesting observations that are owed further study, specifically applied to oligonucleotide cellular delivery, to elucidate additional knowledge into the mechanism. Furthermore, similar results in enhancing cellular uptake and delivery were observed when liposomes were modified with maleimide moieties [53] , which are also prone to react readily with thiol groups. This further supports the evidence indicating the involvement of membrane-embedded cysteine thiol groups.…”

supporting

confidence: 57%

Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability

Maguregui

Abe

2020

ChemBioChem

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There is great potential for siRNA in treatment of diseases through the reduction of damaging protein translation by RNA interference. However, delivery and cell uptake of siRNA poses a serious problem in its therapeutic applications. Methods to overcome this issue include chemical modification of the siRNA duplex to improve pharmacokinetics, stability and efficacy and conjugation to small ligand molecules to enable membrane penetration, targetability and potency. In this review, the most common modifications of siRNA will be discussed, along with ligand conjugates that are believed to be the most promising in advancing the field of targeted siRNA delivery.

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supporting

confidence: 57%

Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability

Maguregui

Abe

2020

ChemBioChem

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“…As we knew that tumor microenvironment plays a key role in tumor proliferation, invasion and metastasis, including hypoxia, acidic pH, high pressure, and abnormal expression of related cytokines and inflammatory response, etc. 13 , 14 Based on extensive research on tumor microenvironment and drug targeting, there is still room for further improvement, “dual” and even “multi-functional” drug carriers have been proposed and developed. 15 Matrix metalloproteases (MMPs) contain a family of zinc-dependent secreted endopeptidases that are of interest due to their ability to degrade extracellular matrices (ECMs).…”

Section: Introductionmentioning

confidence: 99%

<p>Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC</p>

Kong

Zhang

Chu

et al. 2020

IJN

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Background: Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse. Purpose: The objective of this study was to construct a novel CPP (mmp) modified vinorelbine and dioscin liposomes by two new functional materials, DSPE-PEG 2000-MAL and CPP-PVGLIG-PEG 5000 , to destroy VM channels, angiogenesis, EMT and inhibit invasion and migration. Methods and Results: The targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPP (mmp) modified vinorelbine and dioscin liposomes with the ideal physicochemical properties and exhibited enhanced cellular uptake. In vitro and in vivo results showed that CPP (mmp) modified vinorelbine and dioscin liposomes could inhibit migration and invasion of A549 cells, destroy VM channels formation and angiogenesis, and block the EMT process. Pharmacodynamic studies showed that the targeting liposomes had obvious accumulations in tumor sites and magnificent antitumor efficiency. Conclusion: CPP (mmp) modified vinorelbine plus dioscin liposomes could provide a new strategy for NSCLC.

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“…Neutral lipids (DOPE, DPPC, DOPC and Chol) are also often involved in the cationic liposome structure for more efficient transport systems, although sometimes only cationic lipids (DOTAP, DC-Chol, MMRIE, DODAP, DDTAP and DDA) are used [8,36,53]. The choice of ideal colipids is important during the formulation phase [54][55][56], since they significantly affect the overall performance of cationic liposomes.…”

Section: Liposomesmentioning

confidence: 99%

“…This pH sensitivity is important for the vaccination strategies carried out in the treatment of an existing tumor tissue [55]. However, there is no indirect disadvantage of PEG coating on the transfection rate, as there is no intention to improve the present tumor tissue, but there is no need for pH sensitivities for adjuvants in vaccine studies designed to protect against tumor formation [23,54,56,61].…”

Section: Polyethylene Glycol (Peg)mentioning

confidence: 99%

Current State of the Art in DNA Vaccine Delivery and Molecular Adjuvants: Bcl-xL Anti-Apoptotic Protein as a Molecular Adjuvant

Gülce-İz¹,

Sağlam-Metiner²

2019

Immune Response Activation and Immunomodulation

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DNA vaccines (nucleic acid vaccines) have been gaining importance as promising therapeutics against infectious diseases, cancer, autoimmune disorders and allergy for the past two decades. However, the immune responses elicited by the DNA vaccines are not at the desired level to stimulate a protective immune response. Thus, studies are focused on the enhancement of DNA vaccine-induced immune response by different approaches. The most common approach is to use biomaterial-based adjuvants for enhanced antigen delivery and uptake by antigenpresenting cells. Some of these adjuvants are alum, saponins, microspheres, nanoparticles, liposomes, polymers, etc. used in vaccine formulations. In addition, molecular adjuvants like cytokines, chemokines and heat shock proteins have been shown to be promising in designing DNA vaccines. In this chapter, molecular adjuvants to improve DNA vaccination-induced immune responses will be summarized with a special focus on Bcl-xL anti-apoptotic protein.

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A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes

Cited by 17 publications

References 26 publications

Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability

Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability

<p>Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC</p>

Current State of the Art in DNA Vaccine Delivery and Molecular Adjuvants: Bcl-xL Anti-Apoptotic Protein as a Molecular Adjuvant

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