Liposomes as Delivery System for Applications in Meat Products

Li, Huang; Teng, Wendi; Cao, Jinxuan; Wang, Jinpeng

doi:10.3390/foods11193017

Cited by 14 publications

(7 citation statements)

References 93 publications

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“…Increased surface area facilitates higher encapsulation of antimicrobial compounds and consequently, the higher release of the enclosed compound into the food product. Smaller liposomes are easy to diffuse, and homogeneous distribution into the food matrix can be achieved [33]. The PDI value of the liposomes on day 60 was below 0.3, indicating a homogeneous distribution of liposomes in the formulations.…”

Section: Effect Of Storage Temperature On Liposomes' Stabilitymentioning

confidence: 99%

The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method

Ghodke,

Ekonomou,

Weaver

et al. 2023

Foods

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In this study, liposomes enclosing eugenol were prepared using microfluidics. Two lipids—1,2-dimyristoyl-sn-glycero-3-phosphocholine, 18:0 (DSPC) and 2-dimyristoyl-sn-glycero-3-phosphocholine, 14:0 (DMPC)—and microfluidic chips with serpentine and Y-shaped micromixing designs were used for the liposomal formulation. Minimum bactericidal concentration (MBC) values indicated that eugenol was more effective against Gram-negative than Gram-positive bacteria. Four different flow-rate ratios (FRR 2:1, 3:1, 4:1, 5:1) were explored. All liposomes’ encapsulation efficiency (EE) was determined: 94.34% for DSPC 3:1 and 78.63% for DMPC 5:1. The highest eugenol release of 99.86% was observed at pH 4, DMPC 3:1 (Y-shaped chip). Liposomes were physically stable at 4, 20 and 37 °C for 60 days as determined by their size, polydispersity index (PDI) and zeta potential (ZP). The most stable liposomes were observed at FRR 5:1 for DSPC. EE, stability, and eugenol release studies proved that the liposomal formulations produced can be used as delivery vehicles to increase food safety.

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Section: Effect Of Storage Temperature On Liposomes' Stabilitymentioning

confidence: 99%

The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method

Ghodke,

Ekonomou,

Weaver

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…Structurally, liposomes can be categorized into multiple types. Unilamellar liposomes (ULVs) consist of a single lipid bilayer, and they can be further distinguished by their size: small unilamellar vesicles (SUVs) measuring between 20 and 100 nm, large unilamellar vesicles (LUVs) exceeding 100 nm, and giant unilamellar vesicles (GUVs) with sizes above 1000 nm [ 55 ]. On the other hand, multilamellar liposomes (MLVs) feature multiple lipid bilayers and typically have a size greater than 500 nm.…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

“…Additionally, multivesicular liposomes (MVVs) represent a specialized subcategory of multilamellar liposomes, containing smaller unilamellar vesicles within their bilayers, and they typically exceed 1000 nm in size. These vesicles can encapsulate hydrophilic agents within the aqueous core and hydrophobic agents within the lipid bilayer [ 42 , 55 ].…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

Arafat,

Sakkal,

Beiram

et al. 2024

Pharmaceuticals

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Cancer continues to pose one of the most critical challenges in global healthcare. Despite the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting and eliminating cancer cells while minimizing damage to healthy ones, thereby reducing treatment side effects. The revolutionary approach of utilizing nanomaterials for delivering cancer therapeutic agents has significantly enhanced the efficacy and safety of chemotherapeutic drugs. This crucial shift is attributed to the unique properties of nanomaterials, enabling nanocarriers to transport therapeutic agents to tumor sites in both passive and active modes, while minimizing drug elimination from delivery systems. Furthermore, these nanocarriers can be designed to respond to internal or external stimuli, thus facilitating controlled drug release. However, the production of nanomedications for cancer therapy encounters various challenges that can impede progress in this field. This review aims to provide a comprehensive overview of the current state of nanomedication in cancer treatment. It explores a variety of nanomaterials, focusing on their unique properties that are crucial for overcoming the limitations of conventional chemotherapy. Additionally, the review delves into the properties and functionalities of nanocarriers, highlighting their significant impact on the evolution of nanomedicine. It also critically assesses recent advancements in drug delivery systems, covering a range of innovative delivery methodologies. Finally, the review succinctly addresses the challenges encountered in developing nanomedications, offering insightful perspectives to guide future research in this field.

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“…The film effectively inhibited bacterial growth, lipid oxidation, pH changes, and color changes in beef samples, demonstrating its potential for meat preservation. Additionally, Huang and colleagues [116] manufactured chrysanthemum essential oil encapsulated with chitosan and pectin, which reduced oil release and demonstrated sustained antibacterial activity against Campylobacter jejuni in broilers through liposomal delivery.…”

Section: Hybrid Nmsmentioning

confidence: 99%

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

Sadiq,

Khan,

Shen

et al. 2023

Molecules

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Pathogens cause infections and millions of deaths globally, while antipathogens are drugs or treatments designed to combat them. To date, multifunctional nanomaterials (NMs), such as organic, inorganic, and nanocomposites, have attracted significant attention by transforming antipathogen livelihoods. They are very small in size so can quickly pass through the walls of bacterial, fungal, or parasitic cells and viral particles to perform their antipathogenic activity. They are more reactive and have a high band gap, making them more effective than traditional medications. Moreover, due to some pathogen’s resistance to currently available medications, the antipathogen performance of NMs is becoming crucial. Additionally, due to their prospective properties and administration methods, NMs are eventually chosen for cutting-edge applications and therapies, including drug administration and diagnostic tools for antipathogens. Herein, NMs have significant characteristics that can facilitate identifying and eliminating pathogens in real-time. This mini-review analyzes multifunctional NMs as antimicrobial tools and investigates their mode of action. We also discussed the challenges that need to be solved for the utilization of NMs as antipathogens.

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Liposomes as Delivery System for Applications in Meat Products

Cited by 14 publications

References 93 publications

The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method

The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

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