Liposomes and skin: From drug delivery to model membranes

Maghraby, Gamal M. El; Barry, Brian W.; Williams, Adrian C.

doi:10.1016/j.ejps.2008.05.002

Cited by 527 publications

(284 citation statements)

References 118 publications

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“…Some studies have shown that liposomal formulations, associated with organic solvents, terpenes, edge activators (sodium cholate, polysorbate 80 or polysorbate 20) and ethanol, enhance PS penetration through the skin, even to an extent comparable to that of subcutaneous administration (12,19). This enhanced penetration feature is attributed to the high elasticity, small size and high flexibility shown by these vesicles, which are therefore able to squeeze out through narrow constrictions of the skin layers and/or to interact with skin stratum corneum lipids, to solubilize these molecules and to create some channels enabling their permeation through the skin (12,19).…”

Section: Dermal Deliverymentioning

confidence: 99%

Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy

Muehlmann

Joanitti

Silva

et al. 2011

Braz J Med Biol Res

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Section: Dermal Deliverymentioning

confidence: 99%

Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy

Muehlmann

Joanitti

Silva

et al. 2011

Braz J Med Biol Res

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“…32) Furthermore, one of the most important factors during the skin permeation of the drugs was osmotic gradient. Deformable liposomes were reported to penetrate intact skin, carrying therapeutic concentrations of drugs, but only when applied under non-occluded conditions.…”

Section: )mentioning

confidence: 99%

Comparative Study of Novel Ultradeformable Liposomes: Menthosomes, Transfersomes and Liposomes for Enhancing Skin Permeation of Meloxicam

Duangjit

Obata

Sano

et al. 2014

Biological & Pharmaceutical Bulletin

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In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was characterized using confocal laser scanning microscopy (CLSM). The results indicated that the difference in physicochemical characteristics of MTS, TFS and CLP affected the skin permeability. MTS and TFS showed higher flux of MX than CLP. CLSM image showed deformable vesicles mechanism for delivery of MX across the hairless mice skin. Our study suggested that ultradeformable and deformable liposomes (MTS and TFS) had a potential to use as transdermal drug delivery carriers for MX.Key words menthosome; transfersome; liposome; skin permeation; meloxicam; menthol Meloxicam (MX), a cyclooxygenase-2 inhibitor nonsteroidal anti-inflammatory drug (NSAID), is used to treat rheumatoid arthritis, osteoarthritis and other joint diseases. The injectable and oral administrations of NSAID drugs are not appropriate for needle-phobia and peptic ulcer patients. Moreover, the major limitation of MX is its low aqueous solubility (0.012 mg/mL in water and 0.086×10 −2 mg/mL in 0.1 M HCl) 1) with log P 1.91 and 0.07 at pH 5.0 and 7.4, respectively. MX delays its absorption from gastrointestinal tract (GI) and its prolonged use is associated with the incidence of GI side effects (bellyache, indigestion, ulceration and bleeding).2) If MX could be delivered without incidence of these limitations, MX administration would become safer and more acceptable. MX is suitable for development as a transdermal delivery candidate.Transdermal drug delivery or skin delivery has become a global priority because the conventional drug administration is associated with numerous limitations. Liposomes are one of potential strategies that utilize for skin delivery of hydrophilic drugs, 3) lipophilic drugs, 4) protein 5) and macromolecule.6) Although last decades, some design of conventional liposomes are of little or no value as carriers for transdermal drug delivery, but rather remain confined to the upper layer of the stratum corneum. However, recent approaches in vesicular modulating drug delivery through skin have resulted in many designs of novel vesicular carriers e.g., deformable liposomes (transfersomes), 7) niosomes, 8) ethosomes, 9) invasomes, 10) flexosomes 11) and menthosomes. 12) Transfersomes are the first generation of elastic vesicles introduced by Cevc and Blune 7) and consist mainly of phospholipids and an edge activator or a single-chain surfactant which having a high radius of curv...

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“…Lipid vesicular systems are a recognized mode of enhanced delivery of drugs into and through the skin [17]. Our particular interests were recently established ethosomes, soft, malleable vesicles tailored for enhanced delivery of active agents.…”

Section: Methodsmentioning

confidence: 99%

Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture

Thapa¹,

Pepić²,

Vanić³

et al. 2014

Journal of Pharmaceutics and Drug Development

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Annex Publishers | www.annexpublishers.com Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing "revival" in the clinical management of pain. However, the choice of its formulation is rather limited to the use of "old-fashioned" tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin. Moreover, the use of standardized Capsicum extract, rather than a single active ingredient, is proposed to lead to simplified and more cost-effective formulations. Phospholipid-based vesicles, namely liposomes and ethosomes, were prepared with capsaicin, Capsicum tincture or Capsicum powder and characterized for particle size, entrapment efficiency and stability. The vesicular dispersions were incorporated in the hydrogels to increase the formulation stability, its retention time at the skin and overall acceptability. Both the standardized crude Capsicum powder and Capsicum tincture were successfully employed as sources of capsaicin which is, to the best of our knowledge, reported for the first time. The reported phospholipid-based delivery system for capsaicin could represent an improved topical treatment of arthritic pain.

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Liposomes and skin: From drug delivery to model membranes

Cited by 527 publications

References 118 publications

Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy

Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy

Comparative Study of Novel Ultradeformable Liposomes: Menthosomes, Transfersomes and Liposomes for Enhancing Skin Permeation of Meloxicam

Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture

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