Liposomes and phytosomes for phytoconstituents

Karpuz, Merve; Günay, Mine Silindir; Özer, A. Y.

doi:10.1016/b978-0-12-819666-3.00018-3

Cited by 19 publications

(19 citation statements)

References 79 publications

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“…[86][87][88] Besides, phytoconstituent liposomes have been developed to increase the penetration, solubility, and biological impact or to defend against degradation. 89,90 There are many reports of the use of natural extracts via encapsulation in liposomes to improve their bioactivity or to avoid other side effects. 91,92 For example, Gautam et al reported CD44 receptor-phyto-liposomes loaded with stigmasterol (STS) for synergistic chemotherapy.…”

Section: The Liposomementioning

confidence: 99%

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

109

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Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.

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Section: The Liposomementioning

confidence: 99%

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

109

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“…Glycoside phytoconstituents are attractive secondary metabolites due to the physicochemical properties obtained from the sugar complexes, which are of great interest in cancer therapy and can allow their transport through the blood-brain barrier (BBB) via glucose-transport systems. [23][24][25] Several plant-based compounds from various extracts have been shown to possess an anti-inflammatory effect. For instance, caffeoylquinic acids are inhibitors of superoxide production and leukotriene B4 induction, whereas apigenin and quercetin function as anti-inflammatory agents.…”

Section: Artemisia Plants Extraction and Content Analysismentioning

confidence: 99%

“…Phytosomes (also known as herbosomes) are synthetic vesicles containing plant extracts and lipid bilayer membranes (liposomes or niosomes). 25 They are considered an emerging drug delivery system that can encapsulate both hydrophobic and hydrophilic phytoconstituents resulting in enhanced absorption and bioavailability and reduced side effects seen in traditional plant extract treatments. 29 Here, phytoniosomes containing two Artemisia plant extracts (ADR-NIO and ABS-NIO) were synthesised and characterised for their shape, size, encapsulation efficiency, release profile, and shelf-life stability.…”

Section: Phytoniosome Preparation and Characterisationmentioning

confidence: 99%

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Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

Moulahoum

Ghorbanizamani

Khiari

et al. 2022

Phytochemical Analysis

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Introduction:The chronicity of advanced glycation end-products (AGEs) imparts various damages resulting in metabolic dysfunction and diseases involving inflammation and oxidative stress. The use of plant extracts is of high interest in complementary medicine. Yet, extracts are multicomponent mixtures, and difficult to pinpoint their exact mechanism.Objectives: We hypothesise that network pharmacology and bioinformatics can help experimental findings depict the exact active components and mechanism of action by which they induce their effects. Additionally, the toxicity and variability can be lowered and standardised with proper encapsulation methods.Methodology: Here, we propose the formulation of phytoniosomes encapsulating two Artemisia species (Artemisia dracunculus and Artemisia absinthium) to mitigate AGEs and their induced cell redox dysregulation in the liver. Extracts from different solvents were identified via liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS/MS). Phytoniosomes were explored for their antiglycating effect and modulation of AGE-induced damages in THLE-2 liver cells.Network pharmacology tools were used to identify possible targets and signalling pathways implicated.Results: Data demonstrated that A. absinthium phytoniosomes had a significant anti-AGE effect comparable to reference molecules and higher than A. dracunculus. They were able to restore cell dysfunction through the restoration of tumour necrosis alpha (TNF-α), interleukin 6 (IL-6), nitric oxide, and total antioxidant capacity. Phytoniosomes were able to protect cells from apoptosis by decreasing caspase 3 activity.Network pharmacology and bioinformatic analysis confirmed the induction of the effect via Akt-PI3K-MAPK and AGE-RAGE signalling pathways through quercetin and luteolin actions.

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“…The third most important treatment protocol towards prostate cancer is hormone replacement therapy [ 14 ]. Hormone therapy is practiced to hamper the production of male sex hormone (testosterone) [ 15 ]. Diminished testosterone level supply is associated with the slow progression of cancer cells [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

et al. 2020

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The fabrication and development of nanomaterials for the treatment of prostate cancer have gained significant appraisal in recent years. Advancements in synthesis of organic and inorganic nanomaterials with charge, particle size, specified geometry, ligand attachment etc have resulted in greater biocompatibility and active targeting at cancer site. Despite all of the advances made over the years in discovering drugs, methods, and new biomarkers for cancer of the prostate (PCa), PCa remains one of the most troubling cancers among people. Early on, effective diagnosis is an essential part of treating prostate cancer. Prostate-specific antigen (PSA) or serum prostate-specific antigen is the best serum marker widely accessible for diagnosis of PCa. Numerous efforts have been made over the past decade to design new biosensor-based strategies for biomolecules detection and PSA miniaturization biomarkers. The growing nanotechnology is expected to have a significant effect in the immediate future on scientific research and healthcare. Nanotechnology is thus predicted to find a way to solve one of the most and long-standing problem, “early cancer detection”. For early diagnosis of PCa biomarkers, different nanoparticles with different approaches have been used. In this review, we provide a brief description of the latest achievements and advances in the use of nanoparticles for PCa biomarker diagnosis.

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Liposomes and phytosomes for phytoconstituents

Cited by 19 publications

References 79 publications

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

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