Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

Weinstein, John N.; Magin, Richard L.; Yatvin, Milton B.; Zaharko, Daniel S.

doi:10.1126/science.432641

Cited by 329 publications

(130 citation statements)

References 20 publications

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“…Most nanoparticles currently being used are successful by reducing side‐effects or as a means to solubilize hydrophobic drugs to induce fewer side effects 24. However, there has been significant preclinical work focused on developing new strategies for improving the delivery and efficacy of drugs using nanoparticles that are responsive to external stimuli such as heat,25, 26, 27, 28 light,29, 30, 31, 32, 33 ultrasound34 or tumor environment factors such as lower pH35, 36, 37, 38 or expression of certain enzymes 39, 40…”

Section: Introductionmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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Near infrared (NIR) light penetrates human tissues with limited depth, thereby providing a method to safely deliver non‐ionizing radiation to well‐defined target tissue volumes. Light‐based therapies including photodynamic therapy (PDT) and laser‐induced thermal therapy have been validated clinically for curative and palliative treatment of solid tumors. However, these monotherapies can suffer from incomplete tumor killing and have not displaced existing ablative modalities. The combination of phototherapy and chemotherapy (chemophototherapy, CPT), when carefully planned, has been shown to be an effective tumor treatment option preclinically and clinically. Chemotherapy can enhance the efficacy of PDT by targeting surviving cancer cells or by inhibiting regrowth of damaged tumor blood vessels. Alternatively, PDT‐mediated vascular permeabilization has been shown to enhance the deposition of nanoparticulate drugs into tumors for enhanced accumulation and efficacy. Integrated nanoparticles have been reported that combine photosensitizers and drugs into a single agent. More recently, light‐activated nanoparticles have been developed that release their payload in response to light irradiation to achieve improved drug bioavailability with superior efficacy. CPT can potently eradicate tumors with precise spatial control, and further clinical testing is warranted.

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Section: Introductionmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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“…Regarding improvement of tumor specificity of drug delivery, efficient strategies are the use of nano-sized particles with a long circulation property with stimuli-sensitive properties as drug carriers. The former can improve accumulation of the carriers in tumor tissues through the enhanced permeation and retention (EPR) effect [4,5] and the latter can increase therapeutic effect by releasing drug specifically at the diseased tissues upon application of stimuli to the target sites [6][7][8]. In addition, another important function for the improvement of accuracy of drug delivery might be imaging function of carriers [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy

Kono

Nakashima

Kokuryo³

et al. 2011

Biomaterials

111

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“…The potential of using temperature-sensitive liposomes in combination with local hyperthermia for targeted control of local drug release has been shown (68,69). Liposomes remain relatively stable in the circulation at temperatures well below the phase transition temperature (T c ) of the liposome membrane.…”

Section: Ultrasound-facilitated Drug Deliverymentioning

confidence: 99%

The role of ultrasound and magnetic resonance in local drug delivery

Deckers

Rome

Moonen

2008

Magnetic Resonance Imaging

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Local drug delivery has recently attracted much attention since it represents a strategy to increase the drug concentration at the target location and decrease systemic toxicity effects. Ultrasound can be used in different ways to trigger regional drug delivery. It can cause the local drug release from a carrier vehicle and the local increase of cell membrane permeability either by a mechanical action or by a temperature increase. Ultrasound contrast agents may enhance these effects by means of cavitation. Ultrasound can be focused deep inside the body into a small region with dimensions on the order of 1 mm. Several types of drug microcarriers have been proposed, from nano-to micrometer sized particles. The objective of real-time imaging of local drug delivery is to assure that the delivery takes place in the target region, that the drug concentration and the resulting physiological reaction are sufficient, and to intervene if necessary. Ultrasound and nuclear imaging techniques play an important role. MRI is rather insensitive but allows precise targeting of (focused) ultrasound, can provide real-time temperature maps, and gives access to a variety of imaging biomarkers that may be used to assess drug action. Examples from recent articles illustrate the potential of the principles of ultrasound-triggered local drug delivery.

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Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

Cited by 329 publications

References 20 publications

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy

The role of ultrasound and magnetic resonance in local drug delivery

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