Liposome surface modification by phospholipid chemical reactions

Lima, Pedro Henrique Correia de; Butera, Anna Paola; Cabeça, Luis Fernando; Ribeiro-Viana, Renato

doi:10.1016/j.chemphyslip.2021.105084

Cited by 25 publications

(20 citation statements)

References 55 publications

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“…Much effort has been focused on the optimization of the composition of nanocontainers for transdermal delivery and the search for new modifiers. It should be noted that both the fabrication of hybrid nanocarriers by noncovalent coupling and the modification of lipids through various chemical reactions are of practical interest [274]. However, the problem of their biodegradability and targeting has not yet been resolved, which opens up new vectors of research.…”

Section: Discussionmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

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Section: Discussionmentioning

confidence: 99%

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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“…They are amphiphilic molecules that can form liposomes due to self-assembly in water, which is driven by the hydrophobic effect . Liposomes often need to be modified to improve their physical and chemical stability . Previous studies have shown that amphiphilic cholesterol molecules can improve the mechanical stability of liposome bilayers, as well as regulating their fluidity and permeability .…”

Section: Delivery Systems For Phytosterolsmentioning

confidence: 99%

“…71 Liposomes often need to be modified to improve their physical and chemical stability. 72 Previous studies have shown that amphiphilic cholesterol molecules can improve the mechanical stability of liposome bilayers, as well as regulating their fluidity and permeability. 73 In addition, cholesterol can slow down the lateral flow of oxidized phospholipids, inhibit membrane deformation, and prevent the formation of pores, thereby improving liposome stability.…”

Section: Delivery Systems For Phytosterolsmentioning

confidence: 99%

Production, Characterization, Delivery, and Cholesterol-Lowering Mechanism of Phytosterols: A Review

Zhang

Han

McClements

et al. 2022

J. Agric. Food Chem.

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Phytosterols are natural plant-based bioactive compounds that can lower blood cholesterol levels and help prevent cardiovascular diseases. Consequently, they are being utilized in functional foods, supplements, and pharmaceutical products designed to improve human health. This paper summarizes different approaches to isolate, purify, and characterize phytosterols. It also discusses the hypolipidemic mechanisms of phytosterols and their impact on cholesterol transportation. Phytosterols have a low water-solubility, poor chemical stability, and limited bioavailability, which limits their utilization and efficacy in functional foods. Strategies are therefore being developed to overcome these shortcomings. Colloidal delivery systems, such as emulsions, oleogels, liposomes, and nanoparticles, have been shown to be effective at improving the water-dispersibility, stability, and bioavailability of phytosterols. These delivery systems can be used to incorporate phytosterols into a broader range of cholesterol-lowering functional foods and beverages. We also discuses several issues that need to be addressed before these phytosterol delivery systems can find widespread commercial utilization.

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“…Therefore, liposomes have good ability to carry both hydrophilic and hydrophobic drugs in the aqueous lumen and lipid bilayer, respectively, which contributing to the versatility of liposomes. In addition, liposome system also has the advantages of easy modification and targeting potential, which could be constructed with the surface modified with appropriated molecules (or ligands) to actively bind a target molecule of certain cells, system, or tissue ( 14 ). Since Doxil ® was approved by the FDA in 1995 as the first long-circulating liposome for cancer treatment, many chemicals have also been reported to be able to encapsulate liposomes.…”

Section: Lipid-based Nanocarriersmentioning

confidence: 99%

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

Zhang

Wang

et al. 2021

Front. Nutr.

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Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug and food-delivery strategies have received increasingly attentions. Nanocarriers have attracted a large amount of interest as potential carriers of various bioactive molecules for multiple applications. Drug and food-based delivery via polymeric-based nanocarriers and lipid-based nanocarriers has been widely investigated. Nanocarriers, especially liposomes, are more and more widely used in the area of novel nano-pharmaceutical or food-based design. Herein, we aimed to discuss the recent advancement of different surface-engineered nanocarriers type, along with cutting-edge applications for food and nanomedicine and highlight the alternative of phytochemical as nanocarrier. Additionally, safety concern of nanocarriers was also highlighted.

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Liposome surface modification by phospholipid chemical reactions

Cited by 25 publications

References 55 publications

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Production, Characterization, Delivery, and Cholesterol-Lowering Mechanism of Phytosterols: A Review

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

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