Liposome surface charge influence on skin penetration behaviour

Gillet, Aline; Compère, Philippe; Lecomte, Frédéric; Hubert, Pascale; Ducat, Emilie; Évrard, Brigitte; Piel, Géraldine

doi:10.1016/j.ijpharm.2011.03.049

Cited by 110 publications

(72 citation statements)

References 27 publications

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“…In previous study, we discovered that high concentration of ethanol within ethosome reduced the size of the bilayer vesicles and induced a charge transition from positive to negative, which was a favorable physicochemical change for transdermal penetration (Gillet et al, 2011). Furthermore, ethanol has a fluidizing effect on both the ethosomal lipid bilayers and the highly ordered lipophilic structure of stratum corneum.…”

Section: Discussionmentioning

confidence: 95%

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

et al. 2013

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The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3 mg/cm 2 at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p40.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.

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Section: Discussionmentioning

confidence: 95%

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

et al. 2013

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“…Several researchers have outlined that the physicochemical properties of a vesicle can be influenced by modifying the surface charge of vesicle (15). Comparing liposomes consisting of phospholipid alone and transfersomes consisting of phospholipid and edge activator (surfactant), the vesicles of liposomes were different in physicochemical characteristics such as size, charge, morphology and % EE than those of transfersomes.…”

Section: Discussionmentioning

confidence: 99%

“…Positive (3,(11)(12)(13) and negative (4,14,15) effects on skin permeation have been reported for both anionic and cationic transfersomes. Moreover, basic knowledge of surfactants was also required to understand the effect of the carbon chain length and the hydrophilic head group on the enhancement of skin permeation.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of Meloxicam-Loaded Cationic Transfersomes as Transdermal Drug Delivery Carriers

et al. 2012

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Abstract. The aim of this study is to develop meloxicam (MX)-loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes (i.e., particle size, size distribution, droplet surface charge and morphology), entrapment efficiency, stability of formulations and in vitro skin permeation of MX. The transfersomes displayed a spherical structure. Their size, charge, and entrapment efficiency depended on the composition of cholesterol and cationic surfactants in the formulation. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The penetration-enhancing mechanism of skin permeation by the vesicles prepared in this study may be due to the vesicle adsorption to and/or fusion with the stratum corneum. Our results suggest that cationic transfersomes may be promising dermal delivery carriers of MX.

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“…21 However, the effectiveness of anionic surfactants in transdermal liposomes has also been reported. 22,23 The abovementioned hypothetical views evoked our interest in exploring the influence of surface modification in UDLs to improve transdermal drug absorption. Imperatorin (IMP) is an important active compound from the Chinese herbal medicinal plant, Angelica dahurica.…”

Section: Introductionmentioning

confidence: 99%

Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

Lin¹,

Xie²,

Huang³

et al. 2018

IJN

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Aim The aim of this work was to develop a novel vesicular carrier, ultradeformable liposomes (UDLs), to expand the applications of the Chinese herbal medicine, imperatorin (IMP), and increase its transdermal delivery. Methods In this study, we prepared IMP-loaded UDLs using the thin-film hydration method and evaluated their encapsulation efficiency, vesicle deformability, skin permeation, and the amounts accumulated in different depths of the skin in vitro. The influence of different charged surfactants on the properties of the UDLs was also investigated. Results The results showed that the UDLs containing cationic surfactants had high entrapment efficiency (60.32%±2.82%), an acceptable particle size (82.4±0.65 nm), high elasticity, and prolonged drug release. The penetration rate of IMP in cationic-UDLs was 3.45-fold greater than that of IMP suspension, which was the highest value among the vesicular carriers. UDLs modified with cationic surfactant also showed higher fluorescence intensity in deeper regions of the epidermis. Conclusion The results of our study suggest that cationic surfactant-modified UDLs could increase the transdermal flux, prolong the release of the drug, and serve as an effective dermal delivery system for IMP.

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Liposome surface charge influence on skin penetration behaviour

Cited by 110 publications

References 27 publications

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

Evaluation of Meloxicam-Loaded Cationic Transfersomes as Transdermal Drug Delivery Carriers

Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

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