Liposome production by microfluidics: potential and limiting factors

Carugo, Dario; Bottaro, Elisabetta; Owen, Joshua; Stride, Eleanor; Nastruzzi, Claudio

doi:10.1038/srep25876

Cited by 288 publications

(273 citation statements)

References 34 publications

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“…Other techniques especially those based on microfluidics have been extensively developed. These techniques emerged in the late 1980s, include extrusion, double emulsion, droplet emulsion transfer, pulsed jetting, transient membrane ejection, and hydrodynamic focusing [133]. Among these, micro-hydrodynamic focusing was used to fabricate monodisperse liposomes with highly controllable size and encapsulation efficiency through buffer-organic phase flow rate ratios [134].…”

Section: Lipid-based Nanomaterialsmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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Section: Lipid-based Nanomaterialsmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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“…The most basic and earliest methods for liposome formation began with multistep synthetic strategies involving the rehydration of thin phospholipid films in aqueous media which resulted in the spontaneous formation of lipid structures of varying sizes, shapes, and lamella . For uniform product generation, these suspensions required post‐formation mechanical size manipulations strategies . The combination of these methods, although effective and well‐understood, have been proven to be inconvenient for large‐scale manufacture.…”

Section: Liposomal Manufacturingmentioning

confidence: 99%

Potential of Continuous Manufacturing for Liposomal Drug Products

Worsham

Thomas

Farid

2018

Biotechnology Journal

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Over the last several years, continuous manufacturing of pharmaceuticals has evolved from bulk APIs and solid oral dosages into the more complex realm of biologics. The development of continuous downstream processing techniques has allowed biologics manufacturing to realize the benefits (e.g., improved economics, more consistent quality) that come with continuous processing. If relevant processing techniques and principles are selected, the opportunity arises to develop continuous manufacturing designs for additional pharmaceutical products including liposomal drug formulations. Liposome manufacturing has some inherent aspects that make it favorable for a continuous process. Other aspects such as formulation refinement, materials of construction, and aseptic processing need development, but present an achievable challenge. This paper reviews the current state of continuous manufacturing technology applicable to liposomal drug product manufacturing and an assessment of the challenges and potential of this application.

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“…This behavior increases their solubility in the medium and decreases their surface-to-volume ratio. 53,54 There are several methods that can be used to prepare liposomes, including the reverse-phase evaporation technique, injection of phospholipids dissolved in an organic phase into a drug-containing aqueous phase, detergent dialysis, microfluidic hydrodynamic focusing (MHF), supercritical reverse-phase evaporation (SRPE), electroformation, 55 microfluid liposome formation, 56 and thin lipid film hydration (the Bangham method). The last was the first conventional method described for the preparation of liposomes, based on rehydration, in an aqueous solvent, of a thin lipid film formed by evaporating the organic solvent used to solubilize the lipid.…”

Section: Liposomesmentioning

confidence: 99%

Physicochemical characterization of drug nanocarriers

Manaia

Abuçafy

Chiari-Andréo

et al. 2017

IJN

130

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Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical properties, which greatly influence their behavior in the body at both the molecular and systemic levels. This review was conducted to describe the principles and characteristics of techniques commonly used to elucidate the structures of nanocarriers, with consideration of their size, morphology, surface charge, porosity, crystalline arrangement, and phase. These techniques include X-ray diffraction, small-angle X-ray scattering, dynamic light scattering, zeta potential, polarized light microscopy, transmission electron microscopy, scanning electron microcopy, and porosimetry. Moreover, we describe some of the commonly used nanocarriers (liquid crystals, metal–organic frameworks, silica nanospheres, liposomes, solid lipid nanoparticles, and micelles) and the main aspects of their structures.

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Liposome production by microfluidics: potential and limiting factors

Cited by 288 publications

References 34 publications

Evolution and clinical translation of drug delivery nanomaterials

Evolution and clinical translation of drug delivery nanomaterials

Potential of Continuous Manufacturing for Liposomal Drug Products

Physicochemical characterization of drug nanocarriers

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